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Cyp51
Gene Detail
Symbol

Name
ID
Cyp51
cytochrome P450, family 51
MGI:106040
Feature Type
protein coding gene
Genetic Map
Chromosome 5
2.30 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:4081145-4104746 bp, - strand
From VEGA annotation of GRCm38

  23602 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP51A1
Protein SuperFamily: cytochrome P450 CYP51
Gene Tree: Cyp51

Human
homologs
CYP51A1, cytochrome P450, family 51, subfamily A, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1595
neXtProt AC: NX_Q16850

Human Synonyms: CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1

Human Chr (Location): 7q21.2; chr7:92112149-92134745 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit skeletal and craniofacial abnormalities and die at late midgestation due to heart failure resulting from cardiac hypoplasia, ventricle septum, epicardial and vasculogenesis defects.
 
Interactions
Cyp51 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (244)    Tissues (153)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 228
RT-PCR 16
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN cyp51    NEW 
Molecular
reagents
All nucleic(23) Genomic(3) cDNA(16) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000022725 (Evidence)
Ensembl Gene Model ENSMUSG00000001467 (Evidence)
Entrez Gene 13121 (Evidence)
DFCI TC1572086, TC1604375, TC1653835
NIA Mouse Gene Index U005278
EC 1.14.13.70
Consensus CDS Project CCDS19071.1
International Mouse Phenotyping Consortium Status Cyp51
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022725 VEGA Gene Model | MGI Sequence Detail 23602 C57BL/6J ±  kb
transcript OTTMUST00000054505 VEGA | MGI Sequence Detail 3931 Not Applicable 
polypeptide OTTMUSP00000026030 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006147 cytochrome P450 51A1
References
(Earliest) J:35013 Kalb VF, et al., Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiae. Gene. 1986;45(3):237-45
(Latest) J:219777 Santori FR, et al., Identification of natural RORgamma ligands that regulate the development of lymphoid cells. Cell Metab. 2015 Feb 3;21(2):286-97
All references(53)
Other
accession IDs
MGD-MRK-33724, MGI:2140866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory