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Cyp51
Gene Detail
Symbol

Name
ID
Cyp51
cytochrome P450, family 51
MGI:106040
Feature Type
protein coding gene
Genetic Map
Chromosome 5
2.30 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:4081145-4104746 bp, - strand
From VEGA annotation of GRCm38

  23602 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP51
Gene Tree: Cyp51

Human
homologs
Human Homolog CYP51A1, cytochrome P450, family 51, subfamily A, polypeptide 1
NCBI Gene ID 1595
neXtProt AC  NX_Q16850
Human Synonyms  CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Human Chr (Location)  7q21.2; chr7:92112149-92134745 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit skeletal and craniofacial abnormalities and die at late midgestation due to heart failure resulting from cardiac hypoplasia, ventricle septum, epicardial and vasculogenesis defects.
 
Interactions
Cyp51 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (244)    Tissues (153)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 228
RT-PCR 16
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(3) cDNA(16) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022725 (Evidence)
Ensembl Gene ModelENSMUSG00000001467 (Evidence)
Entrez Gene13121 (Evidence)
DFCITC1572086, TC1604375, TC1653835
NIA Mouse Gene IndexU005278
EC1.14.13.70
Consensus CDS ProjectCCDS19071.1
International Mouse Knockout Project StatusCyp51
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022725 VEGA Gene Model | MGI Sequence Detail 23602 C57BL/6J ±  kb
transcript OTTMUST00000054505 VEGA | MGI Sequence Detail 3931 Not Applicable 
polypeptide OTTMUSP00000026030 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006147 cytochrome P450 51A1
References
(Earliest) J:35013 Kalb VF, et al., Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiae. Gene. 1986;45(3):237-45
(Latest) J:197921 Keber R, et al., Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51). J Lipid Res. 2013 Jun;54(6):1653-61
All references(53)
Other
accession IDs
MGD-MRK-33724, MGI:2140866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory