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Mki67 Gene Detail
Summary
  • Symbol
    Mki67
  • Name
    antigen identified by monoclonal antibody Ki 67
  • Synonyms
    D630048A14Rik, Ki67, Ki-67
  • Feature Type
    protein coding gene
  • IDs
    MGI:106035
    NCBI Gene: 17345
  • Gene Overview
    MyGene.info: MKI67
Location & Maps
more
  • Sequence Map
    Chr7:135689784-135716361 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      26578 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 81.32 cM, cytoband F3-F5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIA, MIB-, MIB-1, PPP1R105
  • Links
    NCBI Gene ID: 4288
    neXtProt AC: NX_P46013

  • Chr Location
    10q26.2; chr10:128096659-128126363 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Mice carrying a reporter allele show expression in actively dividing cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    527
  • Tissues
    304
  • cDNA Data
    335
  • Literature Summary
    1181
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060275 VEGA Gene Model | MGI Sequence Detail 26578 C57BL/6J ±  kb
transcript OTTMUST00000147537 VEGA | MGI Sequence Detail 10061 Not Applicable  
polypeptide OTTMUSP00000076785 VEGA | MGI Sequence Detail 3177 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 340
    Genomic 1
    cDNA 336
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33719, MGI:2444351
References
more
  • Summaries
    All 1223
    Developmental Gene Expression 1181
    Gene Ontology 19
    Phenotypes 7
  • Earliest
    J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
  • Latest
    J:234872 Francis KR, et al., Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/beta-catenin defects in neuronal cholesterol synthesis phenotypes. Nat Med. 2016 Apr;22(4):388-96
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory