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Mki67
Gene Detail
 Symbol
Name
ID
Mki67
antigen identified by monoclonal antibody Ki 67
MGI:106035
Synonyms D630048A14Rik, Ki67, Ki-67
Feature Type protein coding gene
Genetic Map
Chromosome 7
81.32 cM, cytoband F3-F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:135689788-135716379 bp, - strand
From NCBI annotation of GRCm38

  26592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mki67

Human
homologs
Human Homolog MKI67, marker of proliferation Ki-67
NCBI Gene ID 4288
neXtProt AC  NX_P46013
Human Synonyms  KIA, MIB-, MIB-1, PPP1R105
Human Chr (Location)  10q26.2; chr10:128096659-128126204 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mki67 interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell proliferation, meiotic nuclear division
Component chromosome, centromeric region, condensed chromosome, ...
Function poly(A) RNA binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (925 records)
Data Summary: Results (412)    Tissues (232)    Images (227)
Theiler Stages: 8, 9, 10, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 274
RNA in situ 120
Northern blot 14
RT-PCR 4
cDNA source data(335)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(340) Genomic(1) cDNA(336) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031004 (Evidence)
Entrez Gene17345 (Evidence)
UniGene4078
DFCITC1572202
DoTSDT.533889
NIA Mouse Gene IndexU029389
Consensus CDS ProjectCCDS52421.1
International Mouse Knockout Project StatusMki67
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17345 NCBI Gene Model | MGI Sequence Detail 26592 C57BL/6J ±  kb
transcript NM_001081117 RefSeq | MGI Sequence Detail 10098 C57BL/6 
polypeptide NP_001074586 RefSeq | MGI Sequence Detail 3177 C57BL/6 

For the selected sequences
All sequences(27) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(128 from dbSNP Build 137)    SNPs within 2kb including multiple locations(130)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR012568 K167R
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000010425 antigen KI-67
References (Earliest) J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
(Latest) J:210661 Seto Y, et al., Characterization of Olig2 expression during cerebellar development. Gene Expr Patterns. 2014 May;15(1):1-7
All references(963)
Other
accession IDs
MGD-MRK-33719, MGI:2444351

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory