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Mki67 Gene Detail
Summary
  • Symbol
    Mki67
  • Name
    antigen identified by monoclonal antibody Ki 67
  • Synonyms
    D630048A14Rik, Ki67, Ki-67
  • Feature Type
    protein coding gene
  • IDs
    MGI:106035
    NCBI Gene: 17345
  • Gene Overview
    MyGene.info: MKI67
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:135689784-135716361 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 81.32 cM, cytoband F3-F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106035
 protein coding gene Chr7:135689784-135716409 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033136
 protein coding gene Chr7:140553479-140581596 (-)
A/J MGP_AJ_G0033118
 protein coding gene Chr7:136621008-136647566 (-)
AKR/J MGP_AKRJ_G0033050
 protein coding gene Chr7:140291437-140329017 (-)
BALB/cJ MGP_BALBcJ_G0033119
 protein coding gene Chr7:136380033-136406667 (-)
C3H/HeJ MGP_C3HHeJ_G0032833
 protein coding gene Chr7:140151747-140180456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033630
 protein coding gene Chr7:145865498-145892056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030603
 protein coding gene Chr7:137855624-137882189 (-)
CAST/EiJ MGP_CASTEiJ_G0032163
 protein coding gene Chr7:132270250-132296844 (-)
CBA/J MGP_CBAJ_G0032806
 protein coding gene Chr7:150759447-150787910 (-)
DBA/2J MGP_DBA2J_G0032958
 protein coding gene Chr7:134629186-134656090 (-)
FVB/NJ MGP_FVBNJ_G0032911
 protein coding gene Chr7:134478779-134505331 (-)
LP/J MGP_LPJ_G0033052
 protein coding gene Chr7:142091130-142118060 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032943
 protein coding gene Chr7:151609603-151641706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033650
 protein coding gene Chr7:139324804-139357704 (-)
PWK/PhJ MGP_PWKPhJ_G0031869
 protein coding gene Chr7:127705518-127737774 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032274
 protein coding gene Chr7:140178239-140207118 (-)



Homology
more
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIA, MIB-, MIB-1, PPP1R105
  • Links
    NCBI Gene ID: 4288
    neXtProt AC: NX_P46013
    UniProt: P46013

  • Chr Location
    10q26.2; chr10:128096659-128126405 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Mice carrying a reporter allele show expression in actively dividing cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    390
  • cDNA Data
    338
  • Literature Summary
    1593
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031004 Ensembl Gene Model | MGI Sequence Detail 26578 C57BL/6J ±  kb
transcript ENSMUST00000033310 Ensembl | MGI Sequence Detail 10061 Not Applicable  
polypeptide ENSMUSP00000033310 Ensembl | MGI Sequence Detail 3177 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 346
    Genomic 1
    cDNA 339
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33719, MGI:2444351
References
more
  • Summaries
    All 1653
    Developmental Gene Expression 1593
    Gene Ontology 21
    Phenotypes 10
  • Earliest
    J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
  • Latest
    J:274227 Wang J, et al., Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 May 1;79(9):2208-2219
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/11/2019
MGI 6.14 		The Jackson Laboratory