Mki67
Gene Detail

Symbol

Name
ID

Mki67
antigen identified by monoclonal antibody Ki 67
MGI:106035

Synonyms

D630048A14Rik, Ki67, Ki-67

Feature Type

protein coding gene

Genetic Map

Chromosome 7
81.32 cM, cytoband F3-F5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:135689788-135716379 bp, - strand From Ensembl annotation of GRCm38   26592 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:1814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mki67

Human
homologs

Human Homolog		MKI67, marker of proliferation Ki-67
NCBI Gene ID		4288
neXtProt AC		NX_P46013
Human Synonyms		KIA, MIB-, MIB-1, PPP1R105
Human Chr (Location)		10q26.2; chr10:128096659-128126204 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Mki67 interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Process	cell proliferation, meiotic nuclear division
Component	chromosome, centromeric region, condensed chromosome, ...
Function	poly(A) RNA binding, protein C-terminus binding

External Resources: FuncBase

Expression

Literature Summary: (1015 records)

Data Summary: Results (421)    Tissues (234)    Images (231)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	283
RNA in situ	120
Northern blot	14
RT-PCR	4

cDNA source data(335)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(340) Genomic(1) cDNA(336) Primer pair(2) Other(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000031004 (Evidence)
Entrez Gene	17345 (Evidence)
UniGene	4078
DFCI	TC1572202
DoTS	DT.533889
NIA Mouse Gene Index	U029389
Consensus CDS Project	CCDS52421.1
International Mouse Knockout Project Status	Mki67

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031004	Ensembl Gene Model | MGI Sequence Detail	26592	C57BL/6J
transcript	ENSMUST00000033310	Ensembl | MGI Sequence Detail	10075	Not Applicable
polypeptide	ENSMUSP00000033310	Ensembl | MGI Sequence Detail	3177	Not Applicable

All sequences(25) RefSeq(8) UniProt(3)

Polymorphisms

SNPs within 2kb(128 from dbSNP Build 137)    SNPs within 2kb including multiple locations(130)

Protein-related
information

Resource	ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR012568	K167R
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000010425	antigen KI-67

References

(Earliest) J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
(Latest) J:217594 Plosa EJ, et al., Epithelial beta1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec;141(24):4751-62
All references(1056)

Other
accession IDs

MGD-MRK-33719, MGI:2444351