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Mki67 Gene Detail
Summary
  • Symbol
    Mki67
  • Name
    antigen identified by monoclonal antibody Ki 67
  • Synonyms
    D630048A14Rik, Ki67, Ki-67
  • Feature Type
    protein coding gene
  • IDs
    MGI:106035
    NCBI Gene: 17345
  • Gene Overview
    MyGene.info: MKI67
Location & Maps
more
  • Sequence Map
    Chr7:135689788-135716379 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26592 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIA, MIB-, MIB-1, PPP1R105
  • Links
    NCBI Gene ID: 4288
    neXtProt AC: NX_P46013

  • Chr Location
    10q26.2; chr10:128096659-128126363 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Mice carrying a reporter allele show expression in actively dividing cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031004 Ensembl Gene Model | MGI Sequence Detail 26592 C57BL/6J ±  kb
transcript ENSMUST00000033310 Ensembl | MGI Sequence Detail 10075 Not Applicable  
polypeptide ENSMUSP00000033310 Ensembl | MGI Sequence Detail 3177 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 340
    Genomic 1
    cDNA 336
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33719, MGI:2444351
References
more
  • Summaries
    All 1172
    Developmental Gene Expression 1133
    Gene Ontology 19
    Phenotypes 7
  • Earliest
    J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
  • Latest
    J:229175 Briggs LE, et al., Wnt/beta-catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion. Dev Dyn. 2016 Feb;245(2):103-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory