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Mki67
Gene Detail
Symbol

Name
ID
Mki67
antigen identified by monoclonal antibody Ki 67
MGI:106035
Synonyms
D630048A14Rik, Ki67, Ki-67
Feature Type
protein coding gene
Genetic Map
Chromosome 7
81.32 cM, cytoband F3-F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:135689788-135716379 bp, - strand
From Ensembl annotation of GRCm38

  26592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MKI67
Gene Tree: Mki67

Human
homologs
MKI67, marker of proliferation Ki-67
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4288
neXtProt AC: NX_P46013

Human Synonyms: KIA, MIB-, MIB-1, PPP1R105

Human Chr (Location): 10q26.2; chr10:128096659-128126363 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Mki67 interacts with 168 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell proliferation, cholangiocyte proliferation, ...
Component chromosome, centromeric region, condensed chromosome, ...
Function poly(A) RNA binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (1064 records)
Data Summary: Results (426)    Tissues (238)    Images (234)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 288
RNA in situ 120
Northern blot 14
RT-PCR 4
cDNA source data(335)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mki67 ; ZFIN mki67    NEW 
Molecular
reagents
All nucleic(340) Genomic(1) cDNA(336) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031004 (Evidence)
Entrez Gene 17345 (Evidence)
UniGene 4078
DFCI TC1572202
DoTS DT.533889
NIA Mouse Gene Index U029389
Consensus CDS Project CCDS52421.1
International Mouse Phenotyping Consortium Status Mki67
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031004 Ensembl Gene Model | MGI Sequence Detail 26592 C57BL/6J ±  kb
transcript ENSMUST00000033310 Ensembl | MGI Sequence Detail 10075 Not Applicable 
polypeptide ENSMUSP00000033310 Ensembl | MGI Sequence Detail 3177 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)    SNPs within 2kb including multiple locations(130)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR012568 K167R
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000010425 antigen KI-67
References
(Earliest) J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
(Latest) J:222255 Knock E, et al., The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Neural Dev. 2015;10:13
All references(1104)
Other
accession IDs
MGD-MRK-33719, MGI:2444351

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory