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St8sia2 Gene Detail
Summary
  • Symbol
    St8sia2
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Synonyms
    Siat8b, ST8SiaII
  • Feature Type
    protein coding gene
  • IDs
    MGI:106020
    NCBI Gene: 20450
  • Gene Overview
    MyGene.info: ST8SIA2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:73939119-74013690 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 42.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106020
protein coding gene Chr7:73939119-74013727 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032371
protein coding gene Chr7:75527775-75602459 (-)
A/J MGP_AJ_G0032350
protein coding gene Chr7:73818578-73893225 (-)
AKR/J MGP_AKRJ_G0032286
protein coding gene Chr7:75377171-75451798 (-)
BALB/cJ MGP_BALBcJ_G0032362
protein coding gene Chr7:73570314-73644957 (-)
C3H/HeJ MGP_C3HHeJ_G0032075
protein coding gene Chr7:76136858-76211371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032854
protein coding gene Chr7:78636542-78712422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029862
protein coding gene Chr7:76450952-76525054 (-)
CAST/EiJ MGP_CASTEiJ_G0031403
protein coding gene Chr7:66982041-67058625 (-)
CBA/J MGP_CBAJ_G0032041
protein coding gene Chr7:81198796-81274856 (-)
DBA/2J MGP_DBA2J_G0032196
protein coding gene Chr7:72484447-72558903 (-)
FVB/NJ MGP_FVBNJ_G0032151
protein coding gene Chr7:72535436-72610055 (-)
LP/J MGP_LPJ_G0032277
protein coding gene Chr7:76756594-76832507 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032188
protein coding gene Chr7:81345477-81421769 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032872
protein coding gene Chr7:74844988-74919643 (-)
PWK/PhJ MGP_PWKPhJ_G0031123
protein coding gene Chr7:65657086-65733357 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030964
protein coding gene Chr7:61936734-62011818 (-)
WSB/EiJ MGP_WSBEiJ_G0031521
protein coding gene Chr7:75201532-75280728 (-)



Homology
more
  • Human Ortholog
    ST8SIA2, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ST8SIA2, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HsT19690, SIAT8B, SIAT8-B, ST8SiaII, ST8SIA-II, STX
  • Links
    NCBI Gene ID: 8128
    neXtProt AC: NX_Q92186
    UniProt: Q92186

  • Chr Location
    15q26.1; chr15:92393910-92468728 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal mossy fiber morphology, increased exploration in new environment and impaired fear responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025789 Ensembl Gene Model | MGI Sequence Detail 74572 C57BL/6J ±  kb
    transcript ENSMUST00000026896 Ensembl | MGI Sequence Detail 5368 Not Applicable  
    polypeptide ENSMUSP00000026896 Ensembl | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 4
      cDNA 76
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33702, MGI:2141905
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:237112 Szewczyk LM, et al., ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons. Glia. 2017 Jan;65(1):34-49

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory