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Adam28
Gene Detail
 Symbol
Name
ID
Adam28
a disintegrin and metallopeptidase domain 28
MGI:105988
Synonyms C130072N01Rik, D430033C21Rik, Dtgn1, MDC-L
Feature Type protein coding gene
Genetic Map
Chromosome 14
35.69 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:68606027-68655842 bp, - strand
From NCBI annotation of GRCm38

  49816 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 western clawed frog

Gene Tree: Adam28

Human
homologs
Human Homolog ADAM28, ADAM metallopeptidase domain 28
NCBI Gene ID 10863
neXtProt AC  NX_Q9UKQ2
Human Synonyms  ADAM23, ADAM 28, eMDCII, eMDC II, MDCL, MDC-L, MDC-Lm, MDC-Ls
Human Chr (Location)  8p21.2; chr8:24294040-24355213 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Adam28 interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process integrin-mediated signaling pathway, proteolysis
Component extracellular region, integral component of membrane, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (69)    Tissues (33)    Images (11)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 22
Northern blot 2
RT-PCR 45
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000014725 (Evidence)
Entrez Gene13522 (Evidence)
UniGene117450
DoTSDT.101295853, DT.101352794, DT.103552442, DT.110755922, DT.40162100, DT.55274485, DT.91308516, DT.91318123, DT.91387907
NIA Mouse Gene IndexU035723
EC3.4.24.-
Consensus CDS ProjectCCDS36964.1, CCDS36965.1
International Mouse Knockout Project StatusAdam28
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13522 NCBI Gene Model | MGI Sequence Detail 49816 C57BL/6J ±  kb
transcript NM_001048175 RefSeq | MGI Sequence Detail 4054 Not Specified 
polypeptide Q9JLN6 UniProt | EBI | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(16) UniProt(4)
Polymorphisms SNPs within 2kb(705 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003720 disintegrin and metalloproteinase domain-containing protein 28
Graphical View of Protein Domain Structure
References (Earliest) J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-33668, MGI:2442612, MGI:2443863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory