Cfb
Gene Detail

Symbol Name ID

Cfb complement factor B MGI:105975

Synonyms

alternative-complement pathway C3/C5 convertase, B, Bf, Factor B, FB, H2-Bf

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr17:34856374-34862518 bp, - strand From VEGA annotation of GRCm38   6145 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 zebrafish

Protein SuperFamily: complement B/C2
Gene Tree: Cfb

Human homologs

Human Homolog		CFB, complement factor B
NCBI Gene ID		629
neXtProt AC		NX_P00751
Human Synonyms		AHUS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Human Chr (Location)		6p21.3; chr6:31913721-31919861 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CFB

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for targeted null mutations lack the alternative complement pathway, and have reduced overall complement activity.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell proliferation, complement activation, ...
Component	extracellular region, extracellular space
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (2)    Images (20)
Theiler Stages: 14, 23

Assay Type	Results
RNA in situ	20
RT-PCR	1

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(14) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034004 (Evidence)
Ensembl Gene Model	ENSMUSG00000090231 (Evidence)
Entrez Gene	14962 (Evidence)
DFCI	TC1572662, TC1637023, TC1670094
NIA Mouse Gene Index	U037725
EC	3.4.21.47
Consensus CDS Project	CCDS28663.2, CCDS50079.1
International Mouse Knockout Project Status	Cfb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034004	VEGA Gene Model | MGI Sequence Detail	6145	C57BL/6J
transcript	OTTMUST00000085838	VEGA | MGI Sequence Detail	2751	Not Applicable
polypeptide	OTTMUSP00000046418	VEGA | MGI Sequence Detail	761	Not Applicable

All sequences(80) RefSeq(4) UniProt(11)

Polymorphisms

RFLP(1) : SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011360	Complement B/C2
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR000436	Sushi/SCR/CCP
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000005374	complement factor B

References

(Earliest) J:13647 Cattanach BM, et al., Crossover suppression in heterozygotes for tobacco mouse metacentric chromosomes. Mouse News Lett. 1974;50:41-2
(Latest) J:194520 Miwa T, et al., Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol. 2013 Apr 1;190(7):3552-9
All references(137)

Other accession IDs

MGD-MRK-1540, MGD-MRK-33655, MGI:2146806, MGI:2146810