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Cfb
Gene Detail
 Symbol
Name
ID
Cfb
complement factor B
MGI:105975
Synonyms alternative-complement pathway C3/C5 convertase, B, Bf, Factor B, FB, H2-Bf
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr17:34856374-34862518 bp, - strand
From VEGA annotation of GRCm38

  6145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 zebrafish

Protein SuperFamily: complement B/C2
Gene Tree: Cfb

Human
homologs
Human Homolog CFB, complement factor B
NCBI Gene ID 629
neXtProt AC  NX_P00751
Human Synonyms  AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2
Human Chr (Location)  6p21.3; chr6:31945944-31952084 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CFB
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations lack the alternative complement pathway, and have reduced overall complement activity.
 
Interactions
Cfb interacts with 65 markers (Mir27b, Mir103-1, Mir127, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell proliferation, complement activation, ...
Component blood microparticle, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (2)    Images (20)
Theiler Stages: 14, 23
Assay TypeResults
RNA in situ 20
RT-PCR 1
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(14) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034004 (Evidence)
Ensembl Gene ModelENSMUSG00000090231 (Evidence)
Entrez Gene14962 (Evidence)
DFCITC1572662, TC1637023, TC1670094
NIA Mouse Gene IndexU037725
EC3.4.21.47
Consensus CDS ProjectCCDS28663.2, CCDS50079.1
International Mouse Knockout Project StatusCfb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034004 VEGA Gene Model | MGI Sequence Detail 6145 C57BL/6J ±  kb
transcript OTTMUST00000085838 VEGA | MGI Sequence Detail 2751 Not Applicable 
polypeptide OTTMUSP00000046418 VEGA | MGI Sequence Detail 761 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(20) UniProt(12)
Polymorphisms RFLP(1) : SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011360 Complement B/C2
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000005374 complement factor B
References (Earliest) J:13647 Cattanach BM, et al., Crossover suppression in heterozygotes for tobacco mouse metacentric chromosomes. Mouse News Lett. 1974;50:41-2
(Latest) J:206648 Baudino L, et al., C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8
All references(145)
Other
accession IDs
MGD-MRK-1540, MGD-MRK-33655, MGI:2146806, MGI:2146810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory