About   Help   FAQ
Hcfc1
Gene Detail
Symbol

Name
ID
Hcfc1
host cell factor C1
MGI:105942
Synonyms
HCF1, HCF-1, VP16 accessory protein
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.52 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:73942792-73966357 bp, - strand
From VEGA annotation of GRCm38

  23566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hcfc1

Human
homologs
Human Homolog HCFC1, host cell factor C1
NCBI Gene ID 3054
neXtProt AC  NX_P51610
Human Synonyms  CFF, HCF, HCF1, HCF-1, HFC1, MRX3, PPP1R89, VCAF
Human Chr (Location)  Xq28; chrX:153947557-153971833 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HCFC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hcfc1 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cell cycle, chromatin modification, ...
Component Ada2/Gcn5/Ada3 transcription activator complex, axon, ...
Function chromatin binding, histone acetyltransferase activity (H4-K16 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(6) cDNA(23)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000017652 (Evidence)
Ensembl Gene ModelENSMUSG00000031386 (Evidence)
Entrez Gene15161 (Evidence)
NIA Mouse Gene IndexU044274, U039463
PDB2M26
Consensus CDS ProjectCCDS30218.1
International Mouse Knockout Project StatusHcfc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017652 VEGA Gene Model | MGI Sequence Detail 23566 C57BL/6J ±  kb
transcript OTTMUST00000043839 VEGA | MGI Sequence Detail 8262 Not Applicable 
polypeptide OTTMUSP00000023005 VEGA | MGI Sequence Detail 2090 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000008470 host cell factor 1
References
(Earliest) J:20730 Frattini A, et al., Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28. Genomics. 1994 Sep 1;23(1):30-5
(Latest) J:196207 Vella P, et al., Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell. 2013 Feb 21;49(4):645-56
All references(42)
Other
accession IDs
MGD-MRK-33621, MGI:2147992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory