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Hcfc1
Gene Detail
Symbol

Name
ID
Hcfc1
host cell factor C1
MGI:105942
Synonyms
HCF1, HCF-1, VP16 accessory protein
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.52 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:73942792-73966357 bp, - strand
From VEGA annotation of GRCm38

  23566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: HCFC1
Gene Tree: Hcfc1

Human
homologs
HCFC1, host cell factor C1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3054
neXtProt AC: NX_P51610

Human Synonyms: CFF, HCF, HCF1, HCF-1, HFC1, MRX3, PPP1R89, VCAF

Human Chr (Location): Xq28; chrX:153947557-153971833 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HCFC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Hcfc1 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cell cycle, chromatin modification, ...
Component Ada2/Gcn5/Ada3 transcription activator complex, axon, ...
Function chromatin binding, histone acetyltransferase activity (H4-K16 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(23)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hcfc1 ; ZFIN hcfc1a    NEW 
Molecular
reagents
All nucleic(29) Genomic(6) cDNA(23)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000017652 (Evidence)
Ensembl Gene Model ENSMUSG00000031386 (Evidence)
Entrez Gene 15161 (Evidence)
NIA Mouse Gene Index U039463, U044274
PDB 2M26
Consensus CDS Project CCDS30218.1
International Mouse Phenotyping Consortium Status Hcfc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017652 VEGA Gene Model | MGI Sequence Detail 23566 C57BL/6J ±  kb
transcript OTTMUST00000043839 VEGA | MGI Sequence Detail 8262 Not Applicable 
polypeptide OTTMUSP00000023005 VEGA | MGI Sequence Detail 2090 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000008470 host cell factor 1
References
(Earliest) J:20730 Frattini A, et al., Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28. Genomics. 1994 Sep 1;23(1):30-5
(Latest) J:209688 Iwata TN, et al., The transcriptional co-regulator HCF-1 is required for INS-1 beta-cell glucose-stimulated insulin secretion. PLoS One. 2013;8(11):e78841
All references(42)
Other
accession IDs
MGD-MRK-33621, MGI:2147992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory