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Hcfc1 Gene Detail
Summary
  • Symbol
    Hcfc1
  • Name
    host cell factor C1
  • Synonyms
    HCF-1, HCF1, VP16 accessory protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:105942
    NCBI Gene: 15161
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72986398-73009963 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.52 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105942
 protein coding gene ChrX:72986398-73011430 (-)
129S1/SvImJ ENSMUSG00200042538
 protein coding gene ChrX:55046992-55070568 (-)
A/J ENSMUSG00195034083
 protein coding gene ChrX:58723225-58746799 (-)
AKR/J ENSMUSG00220046134
 protein coding gene ChrX:54025532-54049109 (-)
BALB/cJ ENSMUSG00180047499
 protein coding gene ChrX:55303970-55327542 (-)
C3H/HeJ ENSMUSG00175032161
 protein coding gene ChrX:58887614-58911183 (-)
C57BL/6NJ ENSMUSG00215038832
 protein coding gene ChrX:55387641-55411210 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033168
 protein coding gene ChrX:68950971-68974594 (-)
CAST/EiJ ENSTCUG00005041869
 protein coding gene ChrX:56805201-56828767 (-)
CBA/J ENSMUSG00210039337
 protein coding gene ChrX:55568288-55591858 (-)
DBA/2J ENSMUSG00185033347
 protein coding gene ChrX:67989917-68013486 (-)
FVB/NJ ENSMUSG00205026850
 protein coding gene ChrX:54869271-54892841 (-)
JF1/MsJ ENSUMUG00000030372
 protein coding gene ChrX:88731058-88754656 (-)
LP/J ENSMUSG00230032096
 protein coding gene ChrX:74569135-74592711 (-)
NOD/ShiLtJ ENSMUSG00190031459
 protein coding gene ChrX:54808270-54831843 (-)
NZO/HlLtJ ENSMUSG00225047335
 protein coding gene ChrX:79773527-79797105 (-)
PWK/PhJ ENSLUMG00010039616
 protein coding gene ChrX:54552357-54575931 (-)
SPRET/EiJ ENSMSPG00010031773
 protein coding gene ChrX:57634435-57658002 (-)
WSB/EiJ ENSIUOG00005048891
 protein coding gene ChrX:55635652-55659208 (-)



Homology
more
  • Human Ortholog
    HCFC1, host cell factor C1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCFC1, host cell factor C1
  • Synonyms
    CFF, HCF, HCF-1, HCF1, HFC1, MAHCX, MRX3, PPP1R89, VCAF, XLID3
  • Links
    NCBI Gene ID: 3054
    UniProt: P51610

  • Chr Location
    Xq28; chrX:153946434-153972427 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hcfc1 mouse models; 1 with human HCFC1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional loss of the maternally inherited allele is embryonic lethal with increased apoptosis and reduced cell proliferation. Liver-specific knockout leads to decreased liver regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    30
  • cDNA Data
    24
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031386 Ensembl Gene Model | MGI Sequence Detail 23566 C57BL/6J ±  kb
    transcript ENSMUST00000114372 Ensembl | MGI Sequence Detail 8262 Not Applicable  
    polypeptide ENSMUSP00000110012 Ensembl | MGI Sequence Detail 2090 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 6
      cDNA 24
      Primer pair 2
      Antibodies 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-33621, MGI:2147992
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 15
      Phenotypes 8
    • Earliest
      J:50113 Taylor KD, et al., Patterns of mRNA prevalence and expression of B1 and B2 transcripts in early mouse embryos. Development. 1987 Dec;101(4):877-92
    • Latest
      J:380624 Ayushma, et al., The HCF-1:OGT axis regulates neuronal proliferation and differentiation. Neurobiol Dis. 2026 Mar;220:107308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory