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Hcfc1 Gene Detail
Summary
  • Symbol
    Hcfc1
  • Name
    host cell factor C1
  • Synonyms
    HCF1, HCF-1, VP16 accessory protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:105942
    NCBI Gene: 15161
  • Gene Overview
    MyGene.info: HCFC1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73942792-73966357 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.52 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105942
protein coding gene ChrX:73942792-73967135 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035828
protein coding gene ChrX:69726867-69750436 (-)
A/J MGP_AJ_G0035809
protein coding gene ChrX:69923288-69946831 (-)
AKR/J MGP_AKRJ_G0035734
protein coding gene ChrX:71767027-71790594 (-)
BALB/cJ MGP_BALBcJ_G0035794
protein coding gene ChrX:68947105-68970669 (-)
C3H/HeJ MGP_C3HHeJ_G0035499
protein coding gene ChrX:70201432-70224982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036324
protein coding gene ChrX:71872931-71896493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033168
protein coding gene ChrX:68950971-68974594 (-)
CAST/EiJ MGP_CASTEiJ_G0034790
protein coding gene ChrX:55551447-55576707 (-)
CBA/J MGP_CBAJ_G0035474
protein coding gene ChrX:73865931-73892413 (-)
DBA/2J MGP_DBA2J_G0035631
protein coding gene ChrX:69374980-69399268 (-)
FVB/NJ MGP_FVBNJ_G0035575
protein coding gene ChrX:68716488-68740306 (-)
LP/J MGP_LPJ_G0035716
protein coding gene ChrX:70509271-70532835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035613
protein coding gene ChrX:76419857-76443409 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036346
protein coding gene ChrX:69550228-69573773 (-)
PWK/PhJ MGP_PWKPhJ_G0034489
protein coding gene ChrX:53559176-53582923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034323
protein coding gene ChrX:56449147-56472934 (-)
WSB/EiJ MGP_WSBEiJ_G0034931
protein coding gene ChrX:68820759-68844859 (-)



Homology
more
  • Human Ortholog
    HCFC1, host cell factor C1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HCFC1, host cell factor C1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFF, HCF, HCF1, HCF-1, HFC1, MRX3, PPP1R89, VCAF
  • Links
    NCBI Gene ID: 3054
    neXtProt AC: NX_P51610
    UniProt: P51610

  • Chr Location
    Xq28; chrX:153947556-153971833 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Conditional loss of the maternally inherited allele is embryonic lethal with increased apoptosis and reduced cell proliferation. Liver-specific knockout leads to decreased liver regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031386 Ensembl Gene Model | MGI Sequence Detail 23566 C57BL/6J ±  kb
    transcript ENSMUST00000114372 Ensembl | MGI Sequence Detail 8262 Not Applicable  
    polypeptide ENSMUSP00000110012 Ensembl | MGI Sequence Detail 2090 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 6
      cDNA 24
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-33621, MGI:2147992
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 5
    • Earliest
      J:50113 Taylor KD, et al., Patterns of mRNA prevalence and expression of B1 and B2 transcripts in early mouse embryos. Development. 1987 Dec;101(4):877-92
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory