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Cfi
Gene Detail
 Symbol
Name
ID
Cfi
complement component factor i
MGI:105937
Feature Type protein coding gene
Genetic Map
Chromosome 3
59.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:129836739-129875328 bp, + strand
From NCBI annotation of GRCm38

  38590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: complement factor I
Gene Tree: Cfi

Human
homologs
Human Homolog CFI, complement factor I
NCBI Gene ID 3426
neXtProt AC  NX_P05156
Human Synonyms  AHUS3, ARMD13, C3b-INA, C3BINA, FI, IF, KAF
Human Chr (Location)  4q25; chr4:109740692-109802225 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CFI
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display uncontrolled alternative pathway activation as shown by reduced complement C3, factor B, and factor H levels, but do not develop C3 deposition along the glomerular basement membrane or membranoproliferative glomerulonephritis type II. Plasma C3 circulates as C3b.
 
Interactions
Cfi interacts with 50 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process complement activation, classical pathway, immune system process, ...
Component extracellular region, extracellular space, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000058952 (Evidence)
Entrez Gene12630 (Evidence)
UniGene117180
DFCITC1579989
DoTSDT.490757
NIA Mouse Gene IndexU003845
EC3.4.21.45
Consensus CDS ProjectCCDS17835.1
International Mouse Knockout Project StatusCfi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12630 NCBI Gene Model | MGI Sequence Detail 38590 C57BL/6J ±  kb
transcript NM_007686 RefSeq | MGI Sequence Detail 2073 C57BL/6 
polypeptide Q61129 UniProt | EBI | MGI Sequence Detail 603 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(10) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(535 from dbSNP Build 137)    SNPs within 2kb including multiple locations(541)
Protein-related
information
ResourceIDDescription
InterPro IPR003884 Factor I / membrane attack complex
InterPro IPR002350 Kazal domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000005384 complement factor I
Graphical View of Protein Domain Structure
References (Earliest) J:31869 Minta JO, et al., cDNA cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): identification of a species specific divergent segment in factor I. Mol Immunol. 1996 Jan;33(1):101-12
(Latest) J:206648 Baudino L, et al., C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8
All references(33)
Other
accession IDs
MGD-MRK-33616

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory