Cfi
Gene Detail

Symbol Name ID

Cfi complement component factor i MGI:105937

Feature Type

protein coding gene

Genetic Map

Chromosome 3

59.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:129836739-129875328 bp, + strand From NCBI annotation of GRCm38   38590 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement factor I
Gene Tree: Cfi

Human homologs

Human Homolog		CFI, complement factor I
NCBI Gene ID		3426
neXtProt AC		NX_P05156
Human Synonyms		AHUS3, C3b-INA, C3BINA, FI, IF, KAF
Human Chr (Location)		4q25; chr4:110661848-110723335 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CFI

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice display uncontrolled alternative pathway activation as shown by reduced complement C3, factor B, and factor H levels, but do not develop C3 deposition along the glomerular basement membrane or membranoproliferative glomerulonephritis type II. Plasma C3 circulates as C3b.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	complement activation, classical pathway, innate immune response, ...
Component	extracellular region, membrane
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000058952 (Evidence)
Entrez Gene	12630 (Evidence)
UniGene	117180
DFCI	TC1579989
DoTS	DT.490757
NIA Mouse Gene Index	U003845
EC	3.4.21.45
Consensus CDS Project	CCDS17835.1
International Mouse Knockout Project Status	Cfi

Sequences

Length	Strain/Species
genomic	12630	NCBI Gene Model | MGI Sequence Detail	38590	C57BL/6J
transcript	NM_007686	RefSeq | MGI Sequence Detail	2073	C57BL/6
polypeptide	Q61129	UniProt | EBI | MGI Sequence Detail	603	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(282 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003884	Factor I / membrane attack complex
InterPro	IPR011497	Kazal-type serine protease inhibitor domain
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR002350	Proteinase inhibitor I1, Kazal
InterPro	IPR001190	Speract/scavenger receptor
InterPro	IPR017448	Speract/scavenger receptor-related
Protein Ontology	PR:000005384	complement factor I

Graphical View of Protein Domain Structure

References

(Earliest) J:31869 Minta JO, et al., cDNA cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): identification of a species specific divergent segment in factor I. Mol Immunol. 1996 Jan;33(1):101-12
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(29)

Other accession IDs

MGD-MRK-33616