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Phenotypes Associated with This Genotype
Genotype
MGI:7507073
Allelic
Composition		 Cfiem1Jiwe/Cfiem1Jiwe
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfiem1Jiwe mutation (0 available); any Cfi mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased mesangial cell number ( J:308307 )
• mesangial expansion after LPS treatment

homeostasis/metabolism
abnormal complement protein level ( J:308307 )
• significant C3 deposits in mesangium after LPS treatment

immune system
abnormal complement protein level ( J:308307 )
• significant C3 deposits in mesangium after LPS treatment
impaired complement alternative pathway ( J:308307 )
• increased complement activity after LPS treatment

cellular
increased mesangial cell number ( J:308307 )
• mesangial expansion after LPS treatment

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glomerulonephritis DOID:2921 J:308307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory