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Lair1 Gene Detail
Summary
  • Symbol
    Lair1
  • Name
    leukocyte-associated Ig-like receptor 1
  • Synonyms
    5133400O11Rik, D7Bwg0421e, Lair-1, mLair-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105492
    NCBI Gene: 52855
  • Gene Overview
    MyGene.info: LAIR1
Location & Maps
more
Homology
more
  • Human Ortholog
    LAIR1, leukocyte associated immunoglobulin like receptor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LAIR1, leukocyte associated immunoglobulin like receptor 1
    Orthology source: HomoloGene
  • Synonyms
    CD305, LAIR-1
  • Links
    NCBI Gene ID: 3903
    neXtProt AC: NX_Q6GTX8

  • Chr Location
    19q13.4; chr19:54353624-54370556 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele are healthy and of normal longevity but show increased numbers of splenic B, regulatory T, and dendritic cells, and eosinophilia at a young age. Aging homozygotes display a higher frequency of activated and effector/memory T cells and a decreased IgG1 level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027896 VEGA Gene Model | MGI Sequence Detail 59778 C57BL/6J ±  kb
transcript OTTMUST00000069096 VEGA | MGI Sequence Detail 2496 Not Applicable  
polypeptide OTTMUSP00000035040 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    347 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-33164, MGI:1918474, MGI:2142289
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:44191 Kubagawa H, et al., A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells [see comments]. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5261-6
  • Latest
    J:180203 Tang X, et al., Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. J Immunol. 2012 Jan 15;188(2):548-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory