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Adam12 Gene Detail
Summary
  • Symbol
    Adam12
  • Name
    a disintegrin and metallopeptidase domain 12 (meltrin alpha)
  • Synonyms
    ADAM12, Mltna
  • Feature Type
    protein coding gene
  • IDs
    MGI:105378
    NCBI Gene: 11489
  • Gene Overview
    MyGene.info: ADAM12
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:133883199-134225097 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 77.61 cM, cytoband F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105378
protein coding gene Chr7:133883199-134232146 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033127
protein coding gene Chr7:138649030-139008880 (-)
A/J MGP_AJ_G0033109
protein coding gene Chr7:134802580-135154342 (-)
AKR/J MGP_AKRJ_G0033041
protein coding gene Chr7:138413704-138763031 (-)
BALB/cJ MGP_BALBcJ_G0033110
protein coding gene Chr7:134520330-134859829 (-)
C3H/HeJ MGP_C3HHeJ_G0032824
protein coding gene Chr7:138262614-138614062 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033621
protein coding gene Chr7:143917631-144289073 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030592
protein coding gene Chr7:136074486-136419843 (-)
CAST/EiJ MGP_CASTEiJ_G0032154
protein coding gene Chr7:130174764-130549320 (-)
CBA/J MGP_CBAJ_G0032797
protein coding gene Chr7:148763380-149152867 (-)
DBA/2J MGP_DBA2J_G0032949
protein coding gene Chr7:132829468-133177173 (-)
FVB/NJ MGP_FVBNJ_G0032902
protein coding gene Chr7:132663925-133012073 (-)
LP/J MGP_LPJ_G0033043
protein coding gene Chr7:140178774-140541256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032934
protein coding gene Chr7:149666710-150040192 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033641
protein coding gene Chr7:137433903-137789920 (-)
PWK/PhJ MGP_PWKPhJ_G0031860
protein coding gene Chr7:125848679-126197403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031706
protein coding gene Chr7:124203747-124557947 (-)
WSB/EiJ MGP_WSBEiJ_G0032265
protein coding gene Chr7:138308556-138664098 (-)



Homology
more
  • Human Ortholog
    ADAM12, ADAM metallopeptidase domain 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAM12, ADAM metallopeptidase domain 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
  • Links
    NCBI Gene ID: 8038
    neXtProt AC: NX_O43184
    UniProt: O43184

  • Chr Location
    10q26.2; chr10:126012385-126388558 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74862
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ADAM12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, decreased brown fat, and impaired formation of neck and interscapular muscles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11489 NCBI Gene Model | MGI Sequence Detail 341899 C57BL/6J ±  kb
    transcript NM_007400 RefSeq | MGI Sequence Detail 7675 C57BL/6  
    polypeptide Q61824 UniProt | EBI | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33047
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:30529 Yagami-Hiromasa T, et al., A metalloprotease-disintegrin participating in myoblast fusion [see comments]. Nature. 1995 Oct 19;377(6550):652-6
    • Latest
      J:212594 Ieguchi K, et al., ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene. 2014 Apr 24;33(17):2179-90

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory