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Adam12 Gene Detail
Summary
  • Symbol
    Adam12
  • Name
    ADAM metallopeptidase domain 12
  • Synonyms
    ADAM12, Mltna
  • Feature Type
    protein coding gene
  • IDs
    MGI:105378
    NCBI Gene: 11489
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:133484928-133826826 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 77.61 cM, cytoband F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105378
 protein coding gene Chr7:133484928-133833875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033127
 protein coding gene Chr7:138649030-139008880 (-)
A/J MGP_AJ_G0033109
 protein coding gene Chr7:134802580-135154342 (-)
AKR/J MGP_AKRJ_G0033041
 protein coding gene Chr7:138413704-138763031 (-)
BALB/cJ MGP_BALBcJ_G0033110
 protein coding gene Chr7:134520330-134859829 (-)
C3H/HeJ MGP_C3HHeJ_G0032824
 protein coding gene Chr7:138262614-138614062 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033621
 protein coding gene Chr7:143917631-144289073 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030592
 protein coding gene Chr7:136074486-136419843 (-)
CAST/EiJ MGP_CASTEiJ_G0032154
 protein coding gene Chr7:130174764-130549320 (-)
CBA/J MGP_CBAJ_G0032797
 protein coding gene Chr7:148763380-149152867 (-)
DBA/2J MGP_DBA2J_G0032949
 protein coding gene Chr7:132829468-133177173 (-)
FVB/NJ MGP_FVBNJ_G0032902
 protein coding gene Chr7:132663925-133012073 (-)
LP/J MGP_LPJ_G0033043
 protein coding gene Chr7:140178774-140541256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032934
 protein coding gene Chr7:149666710-150040192 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033641
 protein coding gene Chr7:137433903-137789920 (-)
PWK/PhJ MGP_PWKPhJ_G0031860
 protein coding gene Chr7:125848679-126197403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031706
 protein coding gene Chr7:124203747-124557947 (-)
WSB/EiJ MGP_WSBEiJ_G0032265
 protein coding gene Chr7:138308556-138664098 (-)



Homology
more
  • Human Ortholog
    ADAM12, ADAM metallopeptidase domain 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM12, ADAM metallopeptidase domain 12
  • Synonyms
    ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
  • Links
    NCBI Gene ID: 8038
    neXtProt AC: NX_O43184
    UniProt: O43184

  • Chr Location
    10q26.2; chr10:126012381-126388477 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADAM12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, decreased brown fat, and impaired formation of neck and interscapular muscles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1184
  • Tissues
    103
  • cDNA Data
    41
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11489 NCBI Gene Model | MGI Sequence Detail 341899 C57BL/6J ±  kb
    transcript NM_007400 RefSeq | MGI Sequence Detail 7708 C57BL/6  
    polypeptide Q61824 UniProt | EBI | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33047
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 11
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:30529 Yagami-Hiromasa T, et al., A metalloprotease-disintegrin participating in myoblast fusion [see comments]. Nature. 1995 Oct 19;377(6550):652-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory