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Adam12
Gene Detail
Symbol

Name
ID
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
MGI:105378
Synonyms
ADAM12, Mltna
Feature Type
protein coding gene
Genetic Map
Chromosome 7
77.61 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:133883199-134232146 bp, - strand
From VEGA annotation of GRCm38

  348948 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74862  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adam12

Human
homologs
Human Homolog ADAM12, ADAM metallopeptidase domain 12
NCBI Gene ID 8038
neXtProt AC  NX_O43184
Human Synonyms  ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
Human Chr (Location)  10q26; chr10:126012385-126388558 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display partial postnatal lethality, decreased brown fat, and impaired formation of neck and interscapular muscles.
 
Interactions
Adam12 interacts with 434 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell adhesion, proteolysis
Component integral component of membrane, membrane, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (474)    Tissues (100)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 474
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(40) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021264 (Evidence)
Ensembl Gene ModelENSMUSG00000054555 (Evidence)
Entrez Gene11489 (Evidence)
UniGene439714
DFCITC1603090, TC1599262, TC1656238
DoTSDT.491423, DT.101724949
NIA Mouse Gene IndexU029378
EC3.4.24.-
Consensus CDS ProjectCCDS21938.1
International Mouse Knockout Project StatusAdam12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021264 VEGA Gene Model | MGI Sequence Detail 348948 C57BL/6J ±  kb
transcript OTTMUST00000050387 VEGA | MGI Sequence Detail 7675 Not Applicable 
polypeptide OTTMUSP00000023508 VEGA | MGI Sequence Detail 903 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(2279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003711 disintegrin and metalloproteinase domain-containing protein 12
References
(Earliest) J:30529 Yagami-Hiromasa T, et al., A metalloprotease-disintegrin participating in myoblast fusion [see comments]. Nature. 1995 Oct 19;377(6550):652-6
(Latest) J:207219 Driskell RR, et al., Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013 Dec 12;504(7479):277-81
All references(53)
Other
accession IDs
MGD-MRK-33047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory