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Adam12 Gene Detail
Summary
  • Symbol
    Adam12
  • Name
    a disintegrin and metallopeptidase domain 12 (meltrin alpha)
  • Synonyms
    ADAM12, Mltna
  • Feature Type
    protein coding gene
  • IDs
    MGI:105378
    NCBI Gene: 11489
  • Gene Overview
    MyGene.info: ADAM12
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:133883199-134232146 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      348948 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 77.61 cM, cytoband F4
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ADAM12, ADAM metallopeptidase domain 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAM12, ADAM metallopeptidase domain 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
  • Links
    NCBI Gene ID: 8038
    neXtProt AC: NX_O43184
    UniProt: O43184

  • Chr Location
    10q26.2; chr10:126012385-126388558 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74862
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ADAM12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, decreased brown fat, and impaired formation of neck and interscapular muscles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021264 VEGA Gene Model | MGI Sequence Detail 348948 C57BL/6J ±  kb
    transcript OTTMUST00000050387 VEGA | MGI Sequence Detail 7675 Not Applicable  
    polypeptide OTTMUSP00000023508 VEGA | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2270 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33047
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:30529 Yagami-Hiromasa T, et al., A metalloprotease-disintegrin participating in myoblast fusion [see comments]. Nature. 1995 Oct 19;377(6550):652-6
    • Latest
      J:212594 Ieguchi K, et al., ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene. 2014 Apr 24;33(17):2179-90

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory