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Spock1 Gene Detail
Summary
  • Symbol
    Spock1
  • Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
  • Synonyms
    testican 1, Ticn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105371
    NCBI Gene: 20745
  • Gene Overview
    MyGene.info: SPOCK1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:57421195-57908332 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.50 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105371
protein coding gene Chr13:57421195-57908332 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020625
protein coding gene Chr13:57011217-57514511 (-)
A/J MGP_AJ_G0020579
protein coding gene Chr13:54895244-55386911 (-)
AKR/J MGP_AKRJ_G0020557
protein coding gene Chr13:56512708-57013575 (-)
BALB/cJ MGP_BALBcJ_G0020575
protein coding gene Chr13:55140590-55629216 (-)
C3H/HeJ MGP_C3HHeJ_G0020374
protein coding gene Chr13:56335610-56833269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021009
protein coding gene Chr13:58764674-59280541 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018591
protein coding gene Chr13:52813972-53302941 (-)
CAST/EiJ MGP_CASTEiJ_G0019888
protein coding gene Chr13:56437520-56960812 (-)
CBA/J MGP_CBAJ_G0020334
protein coding gene Chr13:60988530-61515205 (-)
DBA/2J MGP_DBA2J_G0020457
protein coding gene Chr13:54442045-54931822 (-)
FVB/NJ MGP_FVBNJ_G0020436
protein coding gene Chr13:53913932-54404581 (-)
LP/J MGP_LPJ_G0020533
protein coding gene Chr13:57281577-57793250 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020465
protein coding gene Chr13:60384438-60888571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021052
protein coding gene Chr13:56129860-56628465 (-)
PWK/PhJ MGP_PWKPhJ_G0019644
protein coding gene Chr13:54401594-54922894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019471
protein coding gene Chr13:55041148-55545364 (-)
WSB/EiJ MGP_WSBEiJ_G0019950
protein coding gene Chr13:56511718-57017986 (-)



Homology
more
  • Human Ortholog
    SPOCK1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPOCK1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPOCK, TESTICAN, TIC1
  • Links
    NCBI Gene ID: 6695
    neXtProt AC: NX_Q08629
    UniProt: Q08629

  • Chr Location
    5q31.2; chr5:136975298-137499329 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Mice homozygous for a targeted null mutation display no obvious morphological or behavioral abnormalities, are fertile, and have normal life spans. Adult homozygotes exhibit normal brain morphology and EEG recordings.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20745 NCBI Gene Model | MGI Sequence Detail 487138 C57BL/6J ±  kb
transcript NM_009262 RefSeq | MGI Sequence Detail 4674 C57BL/6  
polypeptide Q62288 UniProt | EBI | MGI Sequence Detail 442 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33040
References
more
  • Summaries
    All 42
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory