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Il6ra Gene Detail
Summary
  • Symbol
    Il6ra
  • Name
    interleukin 6 receptor, alpha
  • Synonyms
    CD126, Il6r, IL-6R, IL-6 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:105304
    NCBI Gene: 16194
  • Gene Overview
    MyGene.info: IL6R
Location & Maps
more
  • Sequence Map
    Chr3:89864059-89913196 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49138 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.19 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    IL6R, interleukin 6 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IL6R, interleukin 6 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD126, gp80, IL6Q, IL-6R-1, IL6RA, IL-6RA, IL6RQ
  • Links
    NCBI Gene ID: 3570
    neXtProt AC: NX_P08887
    UniProt: P08887

  • Chr Location
    1q21.3; chr1:154405193-154469450 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 6 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052883 VEGA Gene Model | MGI Sequence Detail 49138 C57BL/6J ±  kb
transcript OTTMUST00000132340 VEGA | MGI Sequence Detail 8639 Not Applicable  
polypeptide OTTMUSP00000070563 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    146 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    cDNA 16
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11392, MGD-MRK-32345
References
more
  • Summaries
    All 92
    Developmental Gene Expression 12
    Diseases 2
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
  • Latest
    J:240347 Massoud AH, et al., An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. Nat Med. 2016 Sep;22(9):1013-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory