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Il6ra
Gene Detail
Symbol

Name
ID
Il6ra
interleukin 6 receptor, alpha
MGI:105304
Synonyms
CD126, Il6r, IL-6R, IL-6 receptor alpha chain
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:89864059-89913196 bp, - strand
From VEGA annotation of GRCm38

  49138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IL6R
Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Il6ra

Human
homologs
IL6R, interleukin 6 receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3570
neXtProt AC: NX_P08887

Human Synonyms: CD126, gp80, IL6Q, IL-6R-1, IL6RA, IL-6RA, IL6RQ

Human Chr (Location): 1q21; chr1:154405193-154469450 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(3) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.
 
Interactions
Il6ra interacts with 208 markers (Mir15a, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (41)    Tissues (35)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 7
RNase protection 6
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il6r    NEW 
Molecular
reagents
All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000052883 (Evidence)
Ensembl Gene Model ENSMUSG00000027947 (Evidence)
Entrez Gene 16194 (Evidence)
UniGene 2856
DFCI TC1585670, TC1776499
DoTS DT.481894, DT.91444099
NIA Mouse Gene Index U024286
Consensus CDS Project CCDS38496.1, CCDS79954.1
International Mouse Phenotyping Consortium Status Il6ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052883 VEGA Gene Model | MGI Sequence Detail 49138 C57BL/6J ±  kb
transcript OTTMUST00000132340 VEGA | MGI Sequence Detail 8639 Not Applicable 
polypeptide OTTMUSP00000070563 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
InterPro IPR015321 Type I cytokine receptor, cytokine-binding domain
Protein Ontology PR:000001394 interleukin-6 receptor subunit alpha
References
(Earliest) J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
(Latest) J:218188 Eskilsson A, et al., Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. J Neurosci. 2014 Nov 26;34(48):15957-61
All references(80)
Other
accession IDs
MGD-MRK-11392, MGD-MRK-32345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory