Il6ra
Gene Detail

Symbol Name ID

Il6ra interleukin 6 receptor, alpha MGI:105304

Synonyms

CD126, Il6r, IL-6R, IL-6 receptor alpha chain

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:89869324-89913162 bp, - strand From NCBI annotation of GRCm38   43839 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Il6ra

Human homologs

Human Homolog		IL6R, interleukin 6 receptor
NCBI Gene ID		3570
neXtProt AC		NX_P08887
Human Synonyms		CD126, gp80, IL6Q, IL-6R-1, IL6RA, IL-6RA, IL6RQ
Human Chr (Location)		1q21; chr1:154377669-154441926 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IL6R

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	cell growth, ciliary neurotrophic factor-mediated signaling pathway, ...
Component	apical plasma membrane, cell surface, ...
Function	ciliary neurotrophic factor binding, ciliary neurotrophic factor receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (8)   
Theiler Stages: 4, 14, 21, 23, 24, 25, 28

Assay Type	Results
RT-PCR	8
RNase protection	6

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000027947 (Evidence)
Entrez Gene	16194 (Evidence)
UniGene	2856
DFCI	TC1585670, TC1776499
DoTS	DT.481894, DT.91444099
NIA Mouse Gene Index	U024286
Consensus CDS Project	CCDS38496.1
International Mouse Knockout Project Status	Il6ra

Sequences

Length	Strain/Species
genomic	16194	NCBI Gene Model | MGI Sequence Detail	43839	C57BL/6J
transcript	NM_010559	RefSeq | MGI Sequence Detail	3343	C57BL/6
polypeptide	P22272	UniProt | EBI | MGI Sequence Detail	460	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013151	Immunoglobulin
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR015321	Interleukin-6 receptor alpha chain, binding
InterPro	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology	PR:000001394	interleukin-6 receptor subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
(Latest) J:188445 Wunderlich CM, et al., Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012 May 1;188(9):4141-4
All references(67)

Other accession IDs

MGD-MRK-11392, MGD-MRK-32345