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Il6ra Gene Detail
Summary
  • Symbol
    Il6ra
  • Name
    interleukin 6 receptor, alpha
  • Synonyms
    CD126, Il6r, IL-6R, IL-6 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:105304
    NCBI Gene: 16194
Location & Maps
more
  • Sequence Map
    Chr3:89864059-89913196 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49138 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL6R, interleukin 6 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IL6R, interleukin 6 receptor
    Orthology source: HomoloGene
  • Synonyms
    CD126, gp80, IL6Q, IL-6R-1, IL6RA, IL-6RA, IL6RQ
  • Links
    NCBI Gene ID: 3570
    neXtProt AC: NX_P08887

  • Chr Location
    1q21; chr1:154405193-154469450 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Il6ra
  • Incidental Mutations
Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052883 VEGA Gene Model | MGI Sequence Detail 49138 C57BL/6J ±  kb
transcript OTTMUST00000132340 VEGA | MGI Sequence Detail 8639 Not Applicable  
polypeptide OTTMUSP00000070563 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    145 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001394 interleukin-6 receptor subunit alpha
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013151 Immunoglobulin
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 16
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11392, MGD-MRK-32345
References
more
  • Summaries
    All 78
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
  • Latest
    J:218188 Eskilsson A, et al., Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. J Neurosci. 2014 Nov 26;34(48):15957-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory