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Il6ra
Gene Detail
Symbol

Name
ID
Il6ra
interleukin 6 receptor, alpha
MGI:105304
Synonyms
CD126, Il6r, IL-6R, IL-6 receptor alpha chain
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:89869324-89913162 bp, - strand
From NCBI annotation of GRCm38

  43839 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Il6ra

Human
homologs
Human Homolog IL6R, interleukin 6 receptor
NCBI Gene ID 3570
neXtProt AC  NX_P08887
Human Synonyms  CD126, gp80, IL6Q, IL-6R-1, IL6RA, IL-6RA, IL6RQ
Human Chr (Location)  1q21; chr1:154405193-154469450 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(3) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.
 
Interactions
Il6ra interacts with 208 markers (Mir15a, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (41)    Tissues (35)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 7
RNase protection 6
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000027947 (Evidence)
Entrez Gene16194 (Evidence)
UniGene2856
DFCITC1585670, TC1776499
DoTSDT.481894, DT.91444099
NIA Mouse Gene IndexU024286
Consensus CDS ProjectCCDS38496.1
International Mouse Knockout Project StatusIl6ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16194 NCBI Gene Model | MGI Sequence Detail 43839 C57BL/6J ±  kb
transcript NM_010559 RefSeq | MGI Sequence Detail 3343 C57BL/6 
polypeptide P22272 UniProt | EBI | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000001394 interleukin-6 receptor subunit alpha
Graphical View of Protein Domain Structure
References
(Earliest) J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
(Latest) J:209976 Mauer J, et al., Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014 May;15(5):423-30
All references(79)
Other
accession IDs
MGD-MRK-11392, MGD-MRK-32345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory