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Il6ra Gene Detail
Summary
  • Symbol
    Il6ra
  • Name
    interleukin 6 receptor, alpha
  • Synonyms
    CD126, Il6r, IL-6R, IL-6 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:105304
    NCBI Gene: 16194
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89776631-89820503 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.19 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105304
protein coding gene Chr3:89771366-89820503 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027448
protein coding gene Chr3:90102973-90162879 (-)
A/J MGP_AJ_G0027412
protein coding gene Chr3:87120499-87174059 (-)
AKR/J MGP_AKRJ_G0027376
protein coding gene Chr3:89246005-89305782 (-)
BALB/cJ MGP_BALBcJ_G0027421
protein coding gene Chr3:87091730-87141287 (-)
C3H/HeJ MGP_C3HHeJ_G0027163
protein coding gene Chr3:89429874-89484645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027867
protein coding gene Chr3:93491149-93550694 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025219
protein coding gene Chr3:82610344-82661400 (-)
CAST/EiJ MGP_CASTEiJ_G0026609
protein coding gene Chr3:89807975-89860874 (-)
CBA/J MGP_CBAJ_G0027137
protein coding gene Chr3:96722714-96784193 (-)
DBA/2J MGP_DBA2J_G0027275
protein coding gene Chr3:86499290-86549162 (-)
FVB/NJ MGP_FVBNJ_G0027243
protein coding gene Chr3:84835143-84884863 (-)
LP/J MGP_LPJ_G0027384
protein coding gene Chr3:91179659-91235697 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027263
protein coding gene Chr3:102905502-102971359 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027926
protein coding gene Chr3:88987863-89045292 (-)
PWK/PhJ MGP_PWKPhJ_G0026343
protein coding gene Chr3:86386656-86439806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026162
protein coding gene Chr3:88174991-88227237 (-)
WSB/EiJ MGP_WSBEiJ_G0026691
protein coding gene Chr3:89389342-89445402 (-)



Homology
more
  • Human Ortholog
    IL6R, interleukin 6 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL6R, interleukin 6 receptor
  • Synonyms
    CD126, gp80, HIES5, IL-1Ra, IL6Q, IL6QTL, IL-6R, IL-6R-1, IL6RA, IL-6RA, IL6RQ
  • Links
    NCBI Gene ID: 3570
    neXtProt AC: NX_P08887
    UniProt: P08887

  • Chr Location
    1q21.3; chr1:154405193-154469450 (+)  GRCh38

Human Diseases
more
  • Diseases
    5 with human IL6R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 7 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16194 NCBI Gene Model | MGI Sequence Detail 43873 C57BL/6J ±  kb
    transcript NM_010559 RefSeq | MGI Sequence Detail 3377 ZRU/MplStud  
    polypeptide P22272 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11392, MGD-MRK-32345
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 7
      Phenotypes 91
    • Earliest
      J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
    • Latest
      J:344267 Becker M, et al., Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration. Cell Metab. 2023 Oct 3;35(10):1736-1751.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory