Sequence Detail

ID/Version

P22272 (UniProt | EBI)

Last sequence update: 1992-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Interleukin-6 receptor subunit alpha {ECO:0000305}; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: CD_antigen=CD126;Contains: RecN

Provider

SWISS-PROT

Sequence

Polypeptide 460 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il6ra	interleukin 6 receptor, alpha	65	102	3	25

Sequence references in MGI

J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
J:243857 Larsen JV, et al., SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017 Jun 01;37(11)
J:250812 Timper K, et al., IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. Cell Rep. 2017 Apr 11;19(2):267-280
J:260609 Heink S, et al., Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85