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Ntn1 Gene Detail
Summary
  • Symbol
    Ntn1
  • Name
    netrin 1
  • Synonyms
    Netrin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105088
    NCBI Gene: 18208
  • Gene Overview
    MyGene.info: NTN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:68209364-68400823 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      191460 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 41.45 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NTN1, netrin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NTN1, netrin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NTN1L
  • Links
    NCBI Gene ID: 9423
    neXtProt AC: NX_O95631
    UniProt: O95631

  • Chr Location
    17p13.1; chr17:9021542-9244000 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005943 VEGA Gene Model | MGI Sequence Detail 191460 C57BL/6J ±  kb
    transcript OTTMUST00000013235 VEGA | MGI Sequence Detail 5874 Not Applicable  
    polypeptide OTTMUSP00000006137 VEGA | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      995 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 107
      Primer pair 2
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-32128, MGI:2144226, MGI:2652852
    References
    more
    • Summaries
      All 268
      Developmental Gene Expression 154
      Gene Ontology 20
      Phenotypes 82
    • Earliest
      J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
    • Latest
      J:253980 Moreno-Bravo JA, et al., Commissural neurons transgress the CNS/PNS boundary in absence of ventricular zone-derived netrin 1. Development. 2018 Jan 17;145(2):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory