Ntn1 MGI Mouse Gene Detail - MGI:105088

Symbol

Ntn1
Name

netrin 1
Synonyms

Netrin-1

Feature Type

protein coding gene
IDs

MGI:105088
NCBI Gene: 18208
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:68100190-68277652 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 41.45 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

4514 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105088	protein coding gene	Chr11:68100190-68291649 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018499	protein coding gene	Chr11:68546857-68746863 (-)
A/J	MGP_AJ_G0018468	protein coding gene	Chr11:65983602-66176424 (-)
AKR/J	MGP_AKRJ_G0018437	protein coding gene	Chr11:67950017-68144413 (-)
BALB/cJ	MGP_BALBcJ_G0018439	protein coding gene	Chr11:66271453-66465068 (-)
C3H/HeJ	MGP_C3HHeJ_G0018252	protein coding gene	Chr11:67974116-68173435 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018891	protein coding gene	Chr11:70642101-70843812 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016535	protein coding gene	Chr11:62926279-63117853 (-)
CAST/EiJ	MGP_CASTEiJ_G0017808	protein coding gene	Chr11:68191246-68399987 (-)
CBA/J	MGP_CBAJ_G0018226	protein coding gene	Chr11:73773671-73980122 (-)
DBA/2J	MGP_DBA2J_G0018335	protein coding gene	Chr11:65585062-65777749 (-)
FVB/NJ	MGP_FVBNJ_G0018325	protein coding gene	Chr11:65203455-65397997 (-)
LP/J	MGP_LPJ_G0018406	protein coding gene	Chr11:69122321-69319385 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018348	protein coding gene	Chr11:74488999-74689525 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018932	protein coding gene	Chr11:68198738-68393902 (-)
PWK/PhJ	MGP_PWKPhJ_G0017583	protein coding gene	Chr11:66202433-66398584 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017371	protein coding gene	Chr11:68043366-68236277 (-)
WSB/EiJ	MGP_WSBEiJ_G0017861	protein coding gene	Chr11:67814529-68017815 (-)

Human Ortholog

NTN1, netrin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTN1, netrin 1
Synonyms

MRMV4, NET1, NTN1L
Links

HGNC:8029

NCBI Gene ID: 9423

UniProt: O95631
Chr Location

17p13.1; chr17:9003087-9244000 (+) GRCh38

MGI Vertebrate Homology

Ntn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NTN1
Gene Tree

Ntn1

Diseases

1 with human NTN1 associations

				Human Disease	Mouse Models
				congenital mirror movement disorder IDs congenital mirror movement disorder DOID:0111153 OMIM:PS157600 ORDO:238722 UMLS_CUI:C5191311

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

28 phenotypes from 4 alleles in 7 genetic backgrounds
6 phenotypes from multigenic genotypes
125 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

27
Targeted

9
Genomic Mutations

1 involving Ntn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

106 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, optic nerve hypoplasia, motor and balance defects, failure to suckle, and neonatal death. Embryos homozygous for a null allele show bilateral coloboma and cleft secondary palate.

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All GO Annotations

62
GO References

30

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1538
Tissues

304
cDNA Data

108
Literature Summary

219

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NTN3

Xenbase ntn5

ZFIN ntn1a, ntn1b

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All Sequences

46
RefSeq

2
UniProt

2
CCDS

CCDS24864.1

Ensembl

ENSMUSG00000020902 (Evidence)
NCBI Gene

18208

			Length	Strain/Species	Flank
genomic	18208	NCBI Gene Model \| MGI Sequence Detail	177463	C57BL/6J	± kb
transcript	NM_008744	RefSeq \| MGI Sequence Detail	5757	C57BL/6
polypeptide	O09118	UniProt \| EBI \| MGI Sequence Detail	604	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011463 netrin-1

(term hierarchy)
PDB

4OVE, 8SNP
InterPro Domains

IPR008979 Galactose-binding-like domain superfamily

IPR050440 Laminin/Netrin Extracellular Matrix

IPR008211 Laminin, N-terminal

IPR002049 Laminin-type EGF domain

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
GlyGen

O09118 4 sites, 3 N-linked glycans (2 sites)

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All nucleic 145

cDNA 112

Primer pair 10

Other 23

Microarray probesets 5

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MGD-MRK-32128, MGI:2144226, MGI:2652852

Summaries

All 374

Developmental Gene Expression 219

Gene Ontology 30

Phenotypes 125
Earliest

J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
Latest

J:367678 Talbot J, et al., Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival. Nat Commun. 2025 Jun 3;16(1):5137

TSS for Ntn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108575	Chr11:68277994-68278020 (-)	-355 bp
Tssr108574	Chr11:68277800-68277828 (-)	-162 bp
Tssr108573	Chr11:68277769-68277796 (-)	-131 bp
Tssr108572	Chr11:68277757-68277768 (-)	-111 bp
Tssr108571	Chr11:68277725-68277743 (-)	-82 bp
Tssr108570	Chr11:68277697-68277715 (-)	-54 bp
Tssr108569	Chr11:68277667-68277686 (-)	-25 bp
Tssr108568	Chr11:68277647-68277661 (-)	-2 bp
Tssr108567	Chr11:68277631-68277645 (-)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24