Ntn1 MGI Mouse Gene Detail - MGI:105088

Ntn1 Gene Detail

Symbol

Ntn1
Name

netrin 1
Synonyms

Netrin-1

Feature Type

protein coding gene
IDs

MGI:105088
NCBI Gene: 18208
Gene Overview

MyGene.info: NTN1

Sequence Map

Chr11:68209364-68400823 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

191460 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 41.45 cM, cytoband B3
Mapping Data

2 experiments

Human Ortholog

NTN1, netrin 1

Vertebrate Orthologs

9

Human Ortholog

NTN1, netrin 1
Orthology source: HomoloGene, HGNC
Synonyms

NTN1L
Links

HGNC:8029

NCBI Gene ID: 9423

neXtProt AC: NX_O95631

UniProt: O95631
Chr Location

17p13.1; chr17:9021542-9244000 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21008
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: NTN1
Gene Tree

Ntn1

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Phenotype Summary

25 phenotypes from 3 alleles in 6 genetic backgrounds
6 phenotypes from multigenic genotypes
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

200
Chemically induced (other)

1
Gene trapped

191
Targeted

6
Transgenic

2
Genomic Mutations

1 involving Ntn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

94 strains or lines available

Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.

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All GO Annotations

28
GO References

19

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

500
Tissues

177
cDNA Data

105
Literature Summary

142

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NTN3

Xenbase ntn1

ZFIN ntn1a, ntn1b

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Ntn1 interacts with 339 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS24864.1
UniGene

39095

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005943	VEGA Gene Model \| MGI Sequence Detail	191460	C57BL/6J	± kb
transcript	OTTMUST00000013235	VEGA \| MGI Sequence Detail	5874	Not Applicable
polypeptide	OTTMUSP00000006137	VEGA \| MGI Sequence Detail	604	Not Applicable

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SNPs within 2kb

995 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000011463 netrin-1

(term hierarchy)
PDB

4OVE
InterPro Domains

IPR008979 Galactose-binding domain-like

IPR002049 Laminin EGF domain

IPR008211 Laminin, N-terminal

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

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All nucleic 117

cDNA 107

Primer pair 2

Other 8

Microarray probesets 5

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MGD-MRK-32128, MGI:2144226, MGI:2652852

Summaries

All 229

Developmental Gene Expression 142

Gene Ontology 19

Phenotypes 77
Earliest

J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
Latest

J:237125 Miloudi K, et al., Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. J Clin Invest. 2016 Aug 01;126(8):3006-22

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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