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Ntn1
Gene Detail
 Symbol
Name
ID
Ntn1
netrin 1
MGI:105088
Synonyms Netrin-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
41.45 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:68209364-68400823 bp, - strand
From VEGA annotation of GRCm38

  191460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ntn1

Human
homologs
Human Homolog NTN1, netrin 1
NCBI Gene ID 9423
neXtProt AC  NX_O95631
Human Synonyms  NTN1L
Human Chr (Location)  17p13-p12; chr17:9021542-9244000 (+)  GRCh38
Alleles
and
phenotypes
All alleles(192) : Gene trapped(191) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anterior/posterior axon guidance, apoptotic process, ...
Component basement membrane, cell periphery, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (122 records)
Data Summary: Results (478)    Tissues (160)    Images (103)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 20
RNA in situ 409
In situ reporter (knock in) 7
Northern blot 4
RT-PCR 34
RNase protection 4
cDNA source data(104)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(114) cDNA(106) Primer pair(2) Other(6)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005943 (Evidence)
Ensembl Gene ModelENSMUSG00000020902 (Evidence)
Entrez Gene18208 (Evidence)
UniGene39095
Consensus CDS ProjectCCDS24864.1
International Mouse Knockout Project StatusNtn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005943 VEGA Gene Model | MGI Sequence Detail 191460 C57BL/6J ±  kb
transcript OTTMUST00000013235 VEGA | MGI Sequence Detail 5874 Not Applicable 
polypeptide OTTMUSP00000006137 VEGA | MGI Sequence Detail 604 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(995 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR008211 Laminin, N-terminal
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000011463 netrin-1
References (Earliest) J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
(Latest) J:208339 Laumonnerie C, et al., Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system. Development. 2014 Feb;141(3):594-603
All references(191)
Other
accession IDs
MGD-MRK-32128, MGI:2144226, MGI:2652852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory