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Ntn1 Gene Detail
Summary
  • Symbol
    Ntn1
  • Name
    netrin 1
  • Synonyms
    Netrin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105088
    NCBI Gene: 18208
  • Gene Overview
    MyGene.info: NTN1
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68209364-68386826 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 41.45 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    950 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105088
protein coding gene Chr11:68209364-68400823 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018499
protein coding gene Chr11:68546857-68746863 (-)
A/J MGP_AJ_G0018468
protein coding gene Chr11:65983602-66176424 (-)
AKR/J MGP_AKRJ_G0018437
protein coding gene Chr11:67950017-68144413 (-)
BALB/cJ MGP_BALBcJ_G0018439
protein coding gene Chr11:66271453-66465068 (-)
C3H/HeJ MGP_C3HHeJ_G0018252
protein coding gene Chr11:67974116-68173435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018891
protein coding gene Chr11:70642101-70843812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016535
protein coding gene Chr11:62926279-63117853 (-)
CAST/EiJ MGP_CASTEiJ_G0017808
protein coding gene Chr11:68191246-68399987 (-)
CBA/J MGP_CBAJ_G0018226
protein coding gene Chr11:73773671-73980122 (-)
DBA/2J MGP_DBA2J_G0018335
protein coding gene Chr11:65585062-65777749 (-)
FVB/NJ MGP_FVBNJ_G0018325
protein coding gene Chr11:65203455-65397997 (-)
LP/J MGP_LPJ_G0018406
protein coding gene Chr11:69122321-69319385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018348
protein coding gene Chr11:74488999-74689525 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018932
protein coding gene Chr11:68198738-68393902 (-)
PWK/PhJ MGP_PWKPhJ_G0017583
protein coding gene Chr11:66202433-66398584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017371
protein coding gene Chr11:68043366-68236277 (-)
WSB/EiJ MGP_WSBEiJ_G0017861
protein coding gene Chr11:67814529-68017815 (-)



Homology
more
  • Human Ortholog
    NTN1, netrin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NTN1, netrin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NTN1L
  • Links
    NCBI Gene ID: 9423
    neXtProt AC: NX_O95631
    UniProt: O95631

  • Chr Location
    17p13.1; chr17:9021542-9244000 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18208 NCBI Gene Model | MGI Sequence Detail 177463 C57BL/6J ±  kb
    transcript NM_008744 RefSeq | MGI Sequence Detail 5757 C57BL/6  
    polypeptide O09118 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 108
      Primer pair 2
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-32128, MGI:2144226, MGI:2652852
    References
    more
    • Summaries
      All 272
      Developmental Gene Expression 158
      Gene Ontology 22
      Phenotypes 83
    • Earliest
      J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory