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Ntn1
Gene Detail
Symbol

Name
ID
Ntn1
netrin 1
MGI:105088
Synonyms
Netrin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
41.45 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:68209364-68400823 bp, - strand
From VEGA annotation of GRCm38

  191460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: NTN1
Gene Tree: Ntn1

Human
homologs
NTN1, netrin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9423
neXtProt AC: NX_O95631

Human Synonyms: NTN1L

Human Chr (Location): 17p13.1; chr17:9021542-9244000 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(193) : Gene trapped(191) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.
 
Interactions
Ntn1 interacts with 339 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process anterior/posterior axon guidance, apoptotic process, ...
Component basement membrane, cell periphery, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (130 records)
Data Summary: Results (478)    Tissues (162)    Images (103)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 20
RNA in situ 409
In situ reporter (knock in) 7
Northern blot 4
RT-PCR 34
RNase protection 4
cDNA source data(104)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NTN3 ; Xenbase ntn1 ; ZFIN ntn1a, ntn1b    NEW 
Molecular
reagents
All nucleic(114) cDNA(106) Primer pair(2) Other(6)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005943 (Evidence)
Ensembl Gene Model ENSMUSG00000020902 (Evidence)
Entrez Gene 18208 (Evidence)
UniGene 39095
PDB 4OVE
Consensus CDS Project CCDS24864.1
International Mouse Phenotyping Consortium Status Ntn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005943 VEGA Gene Model | MGI Sequence Detail 191460 C57BL/6J ±  kb
transcript OTTMUST00000013235 VEGA | MGI Sequence Detail 5874 Not Applicable 
polypeptide OTTMUSP00000006137 VEGA | MGI Sequence Detail 604 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(995 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR008211 Laminin, N-terminal
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000011463 netrin-1
References
(Earliest) J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
(Latest) J:219821 Kim M, et al., Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction. Dev Biol. 2015 Mar 1;399(1):68-79
All references(207)
Other
accession IDs
MGD-MRK-32128, MGI:2144226, MGI:2652852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory