About   Help   FAQ
Ntn1 Gene Detail
Summary
  • Symbol
    Ntn1
  • Name
    netrin 1
  • Synonyms
    Netrin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105088
    NCBI Gene: 18208
Location & Maps
more
  • Sequence Map
    Chr11:68209364-68400823 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      191460 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NTN1, netrin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NTN1, netrin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NTN1L
  • Links
    NCBI Gene ID: 9423
    neXtProt AC: NX_O95631

  • Chr Location
    17p13.1; chr17:9021542-9244000 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    196
  • Chemically induced (other)
    1
  • Gene trapped
    191
  • Targeted
    2
  • Transgenic
    2
  • Genomic Mutations
    1 involving Ntn1
  • Incidental Mutations
Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005943 VEGA Gene Model | MGI Sequence Detail 191460 C57BL/6J ±  kb
transcript OTTMUST00000013235 VEGA | MGI Sequence Detail 5874 Not Applicable  
polypeptide OTTMUSP00000006137 VEGA | MGI Sequence Detail 604 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    995 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 116
    cDNA 107
    Primer pair 2
    Other 7

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-32128, MGI:2144226, MGI:2652852
References
more
  • Summaries
    All 212
    Developmental Gene Expression 135
    Gene Ontology 19
    Phenotypes 74
  • Earliest
    J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
  • Latest
    J:226697 Yung AR, et al., Phenotypic analysis of mice completely lacking netrin 1. Development. 2015 Nov 1;142(21):3686-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory