Ntn1
Gene Detail

Symbol Name ID

Ntn1 netrin 1 MGI:105088

Synonyms

Netrin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

41.45 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:68209364-68400823 bp, - strand From VEGA annotation of GRCm38   191460 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ntn1

Human homologs

Human Homolog		NTN1, netrin 1
NCBI Gene ID		9423
neXtProt AC		NX_O95631
Human Synonyms		NTN1L
Human Chr (Location)		17p13-p12; chr17:9021542-9244000 (+)  GRCh38

Alleles and phenotypes

All alleles(192) : Gene trapped(191) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	anterior/posterior axon guidance, apoptotic process, ...
Component	basement membrane, cell periphery, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (122 records)

Data Summary: Results (478)    Tissues (160)    Images (103)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	20
RNA in situ	409
In situ reporter (knock in)	7
Northern blot	4
RT-PCR	34
RNase protection	4

cDNA source data(104)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(114) cDNA(106) Primer pair(2) Other(6)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005943 (Evidence)
Ensembl Gene Model	ENSMUSG00000020902 (Evidence)
Entrez Gene	18208 (Evidence)
UniGene	39095
Consensus CDS Project	CCDS24864.1
International Mouse Knockout Project Status	Ntn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005943	VEGA Gene Model | MGI Sequence Detail	191460	C57BL/6J
transcript	OTTMUST00000013235	VEGA | MGI Sequence Detail	5874	Not Applicable
polypeptide	OTTMUSP00000006137	VEGA | MGI Sequence Detail	604	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(995 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR008211	Laminin, N-terminal
InterPro	IPR001134	Netrin domain
InterPro	IPR018933	Netrin module, non-TIMP type
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000011463	netrin-1

References

(Earliest) J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
(Latest) J:208339 Laumonnerie C, et al., Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system. Development. 2014 Feb;141(3):594-603
All references(191)

Other accession IDs

MGD-MRK-32128, MGI:2144226, MGI:2652852