Rbl2
Gene Detail

Symbol Name ID

Rbl2 retinoblastoma-like 2 MGI:105085

Synonyms

p130, Rb2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

44.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:91070057-91123844 bp, + strand From VEGA annotation of GRCm38   53788 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4098  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: retinoblastoma-like protein
Gene Tree: Rbl2

Human homologs

Human Homolog		RBL2, retinoblastoma-like 2 (p130)
NCBI Gene ID		5934
neXtProt AC		NX_Q08999
Human Synonyms		P130, Rb2
Human Chr (Location)		16q12.2; chr16:53468351-53525560 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit arrested embryonic growth and varying disorganization in neural and dermamyotome structures, with death by embryonic day 11-13. On a different background mutants were viable and fertile.

 
Human Diseases Modeled Using Mouse Rbl2 (3)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell cycle, chromatin modification, ...
Component	chromatin, cytoplasm, ...
Function	DNA binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (61)    Tissues (39)    Images (8)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
Northern blot	16
Western blot	35

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031746 (Evidence)
Ensembl Gene Model	ENSMUSG00000031666 (Evidence)
Entrez Gene	19651 (Evidence)
NIA Mouse Gene Index	U009631
Consensus CDS Project	CCDS22518.1
International Mouse Knockout Project Status	Rbl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031746	VEGA Gene Model | MGI Sequence Detail	53788	C57BL/6J
transcript	OTTMUST00000078633	VEGA | MGI Sequence Detail	4925	Not Applicable
polypeptide	OTTMUSP00000041844	VEGA | MGI Sequence Detail	1135	Not Applicable

All sequences(41) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(341 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013763	Cyclin-like
InterPro	IPR024599	Domain of unknown function DUF3452, retinoblastoma-associated
InterPro	IPR002720	Retinoblastoma-associated protein, A-box
InterPro	IPR002719	Retinoblastoma-associated protein, B-box
Protein Ontology	PR:000000119	retinoblastoma-like protein 2

References

(Earliest) J:15699 Yeung RS, et al., The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene. 1993 Dec;8(12):3465-8
(Latest) J:192917 Shin MK, et al., Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Res. 2012 Oct 15;72(20):5418-27
All references(101)

Other accession IDs

MGD-MRK-32125