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Rbl2 Gene Detail
Summary
  • Symbol
    Rbl2
  • Name
    retinoblastoma-like 2
  • Synonyms
    p130, Rb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105085
    NCBI Gene: 19651
  • Gene Overview
    MyGene.info: RBL2
Location & Maps
more
  • Sequence Map
    Chr8:91070057-91123844 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53788 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.25 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RBL2, RB transcriptional corepressor like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RBL2, RB transcriptional corepressor like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P130, Rb2
  • Links
    NCBI Gene ID: 5934
    neXtProt AC: NX_Q08999

  • Chr Location
    16q12.2; chr16:53434439-53491648 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 3 genetic backgrounds
    94 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice generally show no overt phenotype. Homozygotes for a null allele show strain-dependent embryonic lethality and growth arrest associated with altered apoptosis and cell proliferation, impaired neurogenesis and myogenesis, failed embryo turning and heart looping, and thin myocardium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031746 VEGA Gene Model | MGI Sequence Detail 53788 C57BL/6J ±  kb
transcript OTTMUST00000078633 VEGA | MGI Sequence Detail 4925 Not Applicable  
polypeptide OTTMUSP00000041844 VEGA | MGI Sequence Detail 1135 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    648 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000000119 retinoblastoma-like protein 2
  • InterPro Domains
    IPR013763 Cyclin-like
    IPR002720 Retinoblastoma-associated protein, A-box
    IPR002719 Retinoblastoma-associated protein, B-box
    IPR015030 Retinoblastoma-associated protein, C-terminal
    IPR024599 Retinoblastoma-associated protein, N-terminal
    IPR028308 Retinoblastoma-like protein 2
    IPR028309 Retinoblastoma protein family
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-32125
References
more
  • Summaries
    All 117
    Developmental Gene Expression 28
    Diseases 5
    Gene Ontology 9
    Phenotypes 58
  • Earliest
    J:15699 Yeung RS, et al., The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene. 1993 Dec;8(12):3465-8
  • Latest
    J:228312 Tarangelo A, et al., Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory