About   Help   FAQ
Rbl2
Gene Detail
 Symbol
Name
ID
Rbl2
retinoblastoma-like 2
MGI:105085
Synonyms p130, Rb2
Feature Type protein coding gene
Genetic Map
Chromosome 8
44.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:91070057-91123844 bp, + strand
From VEGA annotation of GRCm38

  53788 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4098  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: retinoblastoma-like protein
Gene Tree: Rbl2

Human
homologs
Human Homolog RBL2, retinoblastoma-like 2
NCBI Gene ID 5934
neXtProt AC  NX_Q08999
Human Synonyms  P130, Rb2
Human Chr (Location)  16q12.2; chr16:53434439-53491648 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit arrested embryonic growth and varying disorganization in neural and dermamyotome structures, with death by embryonic day 11-13. On a different background mutants were viable and fertile.
 
Human Diseases Modeled Using Mouse Rbl2 (3)    Alleles Annotated to Human Diseases(3)   
Interactions
Rbl2 interacts with 251 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell cycle, chromatin modification, ...
Component chromatin, cytoplasm, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (67)    Tissues (40)    Images (14)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 16
Northern blot 16
Western blot 35
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031746 (Evidence)
Ensembl Gene ModelENSMUSG00000031666 (Evidence)
Entrez Gene19651 (Evidence)
NIA Mouse Gene IndexU009631
Consensus CDS ProjectCCDS22518.1
International Mouse Knockout Project StatusRbl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031746 VEGA Gene Model | MGI Sequence Detail 53788 C57BL/6J ±  kb
transcript OTTMUST00000078633 VEGA | MGI Sequence Detail 4925 Not Applicable 
polypeptide OTTMUSP00000041844 VEGA | MGI Sequence Detail 1135 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(670 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013763 Cyclin-like
InterPro IPR024599 Domain of unknown function DUF3452, retinoblastoma-associated
InterPro IPR002720 Retinoblastoma-associated protein, A-box
InterPro IPR002719 Retinoblastoma-associated protein, B-box
Protein Ontology PR:000000119 retinoblastoma-like protein 2
References (Earliest) J:15699 Yeung RS, et al., The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene. 1993 Dec;8(12):3465-8
(Latest) J:206810 Han X, et al., Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun. 2014 Feb 17;5:3261
All references(109)
Other
accession IDs
MGD-MRK-32125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory