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Amhr2
Gene Detail
 Symbol
Name
ID
Amhr2
anti-Mullerian hormone type 2 receptor
MGI:105062
Synonyms MISIIR, MIS TypeII receptor
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:102445367-102454630 bp, + strand
From VEGA annotation of GRCm38

  9264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10746  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: anti-muellerian hormone receptor, type II
Gene Tree: Amhr2

Human
homologs
Human Homolog AMHR2, anti-Mullerian hormone receptor, type II
NCBI Gene ID 269
neXtProt AC  NX_Q16671
Human Synonyms  AMHR, MISR2, MISRII, MRII
Human Chr (Location)  12q13; chr12:53423811-53431654 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AMHR2
Alleles
and
phenotypes
All alleles(62) : Gene trapped(55) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant males have a complete male reproductive tract, but also a uterus and oviducts. Functional sperm are produced, but most males are infertile because female reproductive organs block sperm transfer.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process anti-Mullerian hormone signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function anti-Mullerian hormone receptor activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (188)    Tissues (122)    Images (42)
Theiler Stages: 2, 3, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 95
In situ reporter (knock in) 53
RT-PCR 40
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) Genomic(5) cDNA(7) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035015 (Evidence)
Ensembl Gene ModelENSMUSG00000023047 (Evidence)
Entrez Gene110542 (Evidence)
DFCITC1585042
DoTSDT.87026999, DT.94223831
NIA Mouse Gene IndexU016717
EC2.7.11.30
Consensus CDS ProjectCCDS27882.1
International Mouse Knockout Project StatusAmhr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035015 VEGA Gene Model | MGI Sequence Detail 9264 C57BL/6J ±  kb
transcript OTTMUST00000089031 VEGA | MGI Sequence Detail 1938 Not Applicable 
polypeptide OTTMUSP00000048599 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR015771 Anti-muellerian hormone receptor, type II
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
Protein Ontology PR:000000009 anti-Muellerian hormone type-2 receptor
References (Earliest) J:29442 Visser JA, et al., Structure and chromosomal localization of the human anti-mullerian hormone type II receptor gene. Biochem Biophys Res Commun. 1995 Oct 24;215(3):1029-36
(Latest) J:210342 Archambeault DR, et al., Loss of smad4 in Sertoli and Leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice. Biol Reprod. 2014 Mar;90(3):62
All references(137)
Other
accession IDs
MGD-MRK-32101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory