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Amhr2
Gene Detail
Symbol

Name
ID
Amhr2
anti-Mullerian hormone type 2 receptor
MGI:105062
Synonyms
MISIIR, MIS TypeII receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:102445367-102454630 bp, + strand
From VEGA annotation of GRCm38

  9264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10746  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: AMHR2
Protein SuperFamily: anti-muellerian hormone receptor, type II
Gene Tree: Amhr2

Human
homologs
AMHR2, anti-Mullerian hormone receptor, type II
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 269
neXtProt AC: NX_Q16671

Human Synonyms: AMHR, MISR2, MISRII, MRII

Human Chr (Location): 12q13; chr12:53423855-53431534 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AMHR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(55) Radiation induced(1) Targeted(7)
Genomic Mutations involving Amhr2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant males have a complete male reproductive tract, but also a uterus and oviducts. Functional sperm are produced, but most males are infertile because female reproductive organs block sperm transfer.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Amhr2 interacts with 32 markers (Mir130b, Mir322, Mir326, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (25 records)
Data Summary: Results (188)    Tissues (126)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
In situ reporter (knock in) 53
RT-PCR 40
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498418    NEW 
Molecular
reagents
All nucleic(17) Genomic(5) cDNA(7) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035015 (Evidence)
Ensembl Gene Model ENSMUSG00000023047 (Evidence)
Entrez Gene 110542 (Evidence)
DFCI TC1585042
DoTS DT.94223831, DT.87026999
NIA Mouse Gene Index U016717
EC 2.7.11.30
Consensus CDS Project CCDS27882.1
International Mouse Phenotyping Consortium Status Amhr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035015 VEGA Gene Model | MGI Sequence Detail 9264 C57BL/6J ±  kb
transcript OTTMUST00000089031 VEGA | MGI Sequence Detail 1938 Not Applicable 
polypeptide OTTMUSP00000048599 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR015771 Anti-muellerian hormone receptor, type II
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
Protein Ontology PR:000000009 anti-Muellerian hormone type-2 receptor
References
(Earliest) J:29442 Visser JA, et al., Structure and chromosomal localization of the human anti-mullerian hormone type II receptor gene. Biochem Biophys Res Commun. 1995 Oct 24;215(3):1029-36
(Latest) J:218939 Robker RL, et al., Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion. PLoS One. 2014;9(7):e101182
All references(145)
Other
accession IDs
MGD-MRK-32101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory