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Cdh5
Gene Detail
Symbol

Name
ID
Cdh5
cadherin 5
MGI:105057
Synonyms
7B4/cadherin-5, CD144, VEC, VEcad, VE-Cad, VE-cadherin, VECD
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:104101625-104144502 bp, + strand
From Ensembl annotation of GRCm38

  42878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDH5
Protein SuperFamily: cadherin
Gene Tree: Cdh5

Human
homologs
CDH5, cadherin 5, type 2 (vascular endothelium)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1003
neXtProt AC: NX_P33151

Human Synonyms: 7B4, CD144

Human Chr (Location): 16q22.1; chr16:66366622-66404786 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation or cytosolic truncation of this gene causes embryonic growth retardation, abnormal somite and heart development, impaired remodeling and maturation of endothelial cells, increased endothelial apoptosis and severe vascular defects leading to embryonic death at midgestation.
 
Interactions
Cdh5 interacts with 215 markers (Mir1a-1, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process blood vessel maturation, cell adhesion, ...
Component adherens junction, bicellular tight junction, ...
Function beta-catenin binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (152 records)
Data Summary: Results (300)    Tissues (197)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 183
Western blot 10
RT-PCR 85
cDNA source data(71)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDH5 ; Xenbase cdh5 ; ZFIN cdh5    NEW 
Molecular
reagents
All nucleic(87) Genomic(6) cDNA(71) Primer pair(9) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000031871 (Evidence)
Entrez Gene 12562 (Evidence)
UniGene 21767
DFCI TC1577476
DoTS DT.99856378, DT.490846, DT.101190138
NIA Mouse Gene Index U009715
PDB 2KOH
Consensus CDS Project CCDS22572.1
International Mouse Phenotyping Consortium Status Cdh5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031871 Ensembl Gene Model | MGI Sequence Detail 42878 C57BL/6J ±  kb
transcript ENSMUST00000034339 Ensembl | MGI Sequence Detail 3986 Not Applicable 
polypeptide ENSMUSP00000034339 Ensembl | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001444 cadherin-5
References
(Earliest) J:30623 Breier G, et al., Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. (Errata: vol. 88(3):1129-33). Blood. 1996 Jan 15;87(2):630-41
(Latest) J:221893 Yamamoto H, et al., Integrin beta1 controls VE-cadherin localization and blood vessel stability. Nat Commun. 2015;6:6429
All references(207)
Other
accession IDs
MGD-MRK-32096, MGI:2142402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory