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Cdh5 Gene Detail
Summary
  • Symbol
    Cdh5
  • Name
    cadherin 5
  • Synonyms
    7B4/cadherin-5, CD144, VEC, VEcad, VE-Cad, VE-cadherin, VECD
  • Feature Type
    protein coding gene
  • IDs
    MGI:105057
    NCBI Gene: 12562
  • Gene Overview
    MyGene.info: CDH5
Location & Maps
more
  • Sequence Map
    Chr8:104101625-104144511 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42887 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CDH5, cadherin 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDH5, cadherin 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    7B4, CD144
  • Links
    NCBI Gene ID: 1003
    neXtProt AC: NX_P33151

  • Chr Location
    16q21; chr16:66366622-66404786 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1359
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDH5
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 12 alleles in 9 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation or cytosolic truncation of this gene causes embryonic growth retardation, abnormal somite and heart development, impaired remodeling and maturation of endothelial cells, increased endothelial apoptosis and severe vascular defects leading to embryonic death at midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061476 VEGA Gene Model | MGI Sequence Detail 42887 C57BL/6J ±  kb
transcript OTTMUST00000150025 VEGA | MGI Sequence Detail 3995 Not Applicable  
polypeptide OTTMUSP00000077796 VEGA | MGI Sequence Detail 784 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    123 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 87
    Genomic 6
    cDNA 71
    Primer pair 9
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-32096, MGI:2142402
References
more
  • Summaries
    All 233
    Developmental Gene Expression 171
    Gene Ontology 16
    Phenotypes 21
  • Earliest
    J:30623 Breier G, et al., Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. (Errata: vol. 88(3):1129-33). Blood. 1996 Jan 15;87(2):630-41
  • Latest
    J:236001 Zhang H, et al., Endocardium Contributes to Cardiac Fat. Circ Res. 2016 Jan 22;118(2):254-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory