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Cdh5
Gene Detail
 Symbol
Name
ID
Cdh5
cadherin 5
MGI:105057
Synonyms 7B4/cadherin-5, CD144, VEC, VEcad, VE-Cad, VE-cadherin, VECD
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:104101625-104144502 bp, + strand
From NCBI annotation of GRCm38

  42878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh5

Human
homologs
Human Homolog CDH5, cadherin 5, type 2 (vascular endothelium)
NCBI Gene ID 1003
neXtProt AC  NX_P33151
Human Synonyms  7B4, CD144
Human Chr (Location)  16q22.1; chr16:66366622-66404786 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation or cytosolic truncation of this gene causes embryonic growth retardation, abnormal somite and heart development, impaired remodeling and maturation of endothelial cells, increased endothelial apoptosis and severe vascular defects leading to embryonic death at midgestation.
 
Interactions
Cdh5 interacts with 216 markers (Mir1a-1, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process blood vessel maturation, cell adhesion, ...
Component adherens junction, cell-cell junction, ...
Function beta-catenin binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (128 records)
Data Summary: Results (265)    Tissues (168)    Images (76)
Theiler Stages: 2, 3, 11, 12, 13, 15, 17, 19, 20, 22, 23, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 183
Western blot 10
RT-PCR 57
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(6) cDNA(71) Primer pair(8) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000031871 (Evidence)
Entrez Gene12562 (Evidence)
UniGene21767
DFCITC1577476
DoTSDT.101190138, DT.490846, DT.99856378
NIA Mouse Gene IndexU009715
PDB2KOH
Consensus CDS ProjectCCDS22572.1
International Mouse Knockout Project StatusCdh5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12562 NCBI Gene Model | MGI Sequence Detail 42878 C57BL/6J ±  kb
transcript NM_009868 RefSeq | MGI Sequence Detail 4004 C57BL/6 
polypeptide P55284 UniProt | EBI | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001444 cadherin-5
Graphical View of Protein Domain Structure
References (Earliest) J:30623 Breier G, et al., Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. (Errata: vol. 88(3):1129-33). Blood. 1996 Jan 15;87(2):630-41
(Latest) J:207212 Oh WJ, et al., Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 2013 Oct 16;80(2):458-69
All references(180)
Other
accession IDs
MGD-MRK-32096, MGI:2142402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory