Automated description from the Alliance of Genome Resources (Release 8.2.0)
Enables cell-cell adhesion mediator activity and protein phosphatase binding activity. Involved in cell migration involved in sprouting angiogenesis; endothelial cell morphogenesis; and regulation of establishment of cell polarity. Acts upstream of or within blood vessel maturation; cell-cell adhesion; and negative regulation of cell population proliferation. Located in bicellular tight junction; cytoplasm; and external side of plasma membrane. Is active in adherens junction. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and limb. Used to study exudative vitreoretinopathy. Orthologous to human CDH5 (cadherin 5).
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