Serpina3g
Gene Detail

Symbol Name ID

Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G MGI:105046

Synonyms

2A2, alpha-1 antiproteinase, alpha-1 antiproteinase,, Spi2-1, Spi2A, Spi2/eb.1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

53.71 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:104236245-104241939 bp, + strand From VEGA annotation of GRCm38   5695 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:115927  Vertebrate Homology Class
3 mouse; 1 rat

Protein SuperFamily: serpin
Gene Tree: Serpina3g

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit impaired memory T cell homeostatic proliferation, decreased CD8+ T cells and antigen-specific CD8+ T cells after LCMV infection.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	apoptotic process, negative regulation of endopeptidase activity, ...
Component	cytoplasm, extracellular region, ...
Function	cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (2)    Images (1)
Theiler Stages: 26, 28

Assay Type	Results
Northern blot	8

cDNA source data(11)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000035423 (Evidence)
Ensembl Gene Model	ENSMUSG00000041481 (Evidence)
Entrez Gene	20715 (Evidence)
International Mouse Knockout Project Status	Serpina3g

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035423	VEGA Gene Model | MGI Sequence Detail	5695	C57BL/6J
transcript	OTTMUST00000090576	VEGA | MGI Sequence Detail	1803	Not Applicable
polypeptide	OTTMUSP00000049724	VEGA | MGI Sequence Detail	248	Not Applicable

All sequences(40) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(265 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000015937	serine protease inhibitor A3G

References

(Earliest) J:698 Inglis JD, et al., Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991 Oct 15;106(2):213-20
(Latest) J:189782 Byrne SM, et al., Cathepsin B controls the persistence of memory CD8+ T lymphocytes. J Immunol. 2012 Aug 1;189(3):1133-43
All references(28)

Other accession IDs

MGD-MRK-32085, MGI:2144764