Serpina3g MGI Mouse Gene Detail - MGI:105046 - serine (or cysteine) peptidase inhibitor, clade A, member 3G

Symbol

Serpina3g
Name

serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms

2A2, alpha-1 antiproteinase, alpha-1 antiproteinase,, Spi2-1, Spi2A, Spi2/eb.1

Feature Type

protein coding gene
IDs

MGI:105046
NCBI Gene: 20715
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:104202504-104208198 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 53.71 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

214 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105046	protein coding gene	Chr12:104202406-104208198 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020071	protein coding gene	Chr12:105996946-106005533 (+)
A/J	MGP_AJ_G0020025	protein coding gene	Chr12:101997934-102003258 (+)
AKR/J	MGP_AKRJ_G0020003	protein coding gene	Chr12:104893408-104900761 (+)
BALB/cJ	MGP_BALBcJ_G0020010	protein coding gene	Chr12:102354925-102361350 (+)
C3H/HeJ	MGP_C3HHeJ_G0019814	protein coding gene	Chr12:105374994-105381582 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020457	protein coding gene	Chr12:109315158-109322891 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0019357	protein coding gene	Chr12:100173396-100179513 (+)
CBA/J	MGP_CBAJ_G0019780	protein coding gene	Chr12:113379933-113483210 (+)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0019884	protein coding gene	Chr12:100292663-100312567 (+)
LP/J	MGP_LPJ_G0019972	protein coding gene	Chr12:105838028-105844335 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019921	protein coding gene	Chr12:116842559-116890214 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020486	protein coding gene	Chr12:104363383-104369077 (+)
PWK/PhJ	MGP_PWKPhJ_G0019118	protein coding gene	Chr12:95964137-95978290 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018918	protein coding gene	Chr12:98584378-98588134 (+)
WSB/EiJ	MGP_WSBEiJ_G0019415	protein coding gene	Chr12:105256203-105317524 (+)

Human Ortholog

SERPINA3, serpin family A member 3

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINA3, serpin family A member 3
Synonyms

AACT, ACT, GIG24, GIG25
Links

HGNC:16

NCBI Gene ID: 12

neXtProt AC: NX_P01011

UniProt: P01011
Chr Location

14q32.13; chr14:94612384-94624055 (+) GRCh38

MGI Vertebrate Homology

Serpina3g stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: SERPINA3
Gene Tree

Serpina3g

Diseases

3 with human SERPINA3 associations

				Human Disease	Mouse Models
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				vasculitis IDs vasculitis DOID:865 MESH:D014657 NCI:C26912 UMLS_CUI:C0042384

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Targeted

1
Genomic Mutations

1 involving Serpina3g
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired memory T cell homeostatic proliferation, decreased CD8+ T cells and antigen-specific CD8+ T cells after LCMV infection.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

2
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

54
RefSeq

6
UniProt

6
CCDS

CCDS88397.1

Ensembl

ENSMUSG00000041481 (Evidence)
NCBI Gene

20715

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041481	Ensembl Gene Model \| MGI Sequence Detail	5695	C57BL/6J	± kb
transcript	ENSMUST00000043315	Ensembl \| MGI Sequence Detail	1945	Not Applicable
polypeptide	ENSMUSP00000041250	Ensembl \| MGI Sequence Detail	248	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015937 serine protease inhibitor A3G

(term hierarchy)
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 16

cDNA 15

Other 1

Microarray probesets 2

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MGD-MRK-32085, MGI:2144764

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 4
Earliest

J:698 Inglis JD, et al., Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991 Oct 15;106(2):213-20
Latest

J:315615 Shamji MH, et al., Antiapoptotic serine protease inhibitors contribute to survival of allergenic TH2 cells. J Allergy Clin Immunol. 2018 Aug;142(2):569-581.e5

TSS for Serpina3g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114835	Chr12:104202385-104202409 (+)	-107 bp
Tssr114836	Chr12:104202498-104202504 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23