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Serpina3g
Gene Detail
 Symbol
Name
ID
Serpina3g
serine (or cysteine) peptidase inhibitor, clade A, member 3G
MGI:105046
Synonyms 2A2, alpha-1 antiproteinase, alpha-1 antiproteinase,, Spi2-1, Spi2A, Spi2/eb.1
Feature Type protein coding gene
Genetic Map
Chromosome 12
53.71 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:104236245-104241939 bp, + strand
From VEGA annotation of GRCm38

  5695 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115927  Vertebrate Homology Class
3 mouse; 1 rat

Protein SuperFamily: serpin
Gene Tree: Serpina3g

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired memory T cell homeostatic proliferation, decreased CD8+ T cells and antigen-specific CD8+ T cells after LCMV infection.
 
Interactions
Serpina3g interacts with 79 markers (Mir18, Mir23b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic process, immune system process, ...
Component cytoplasm, extracellular region, ...
Function cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (2)    Images (1)
Theiler Stages: 26, 28
Assay TypeResults
Northern blot 8
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035423 (Evidence)
Ensembl Gene ModelENSMUSG00000041481 (Evidence)
Entrez Gene20715 (Evidence)
International Mouse Knockout Project StatusSerpina3g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035423 VEGA Gene Model | MGI Sequence Detail 5695 C57BL/6J ±  kb
transcript OTTMUST00000090576 VEGA | MGI Sequence Detail 1803 Not Applicable 
polypeptide OTTMUSP00000049724 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(323 from dbSNP Build 137)    SNPs within 2kb including multiple locations(381)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015937 serine protease inhibitor A3G
References (Earliest) J:698 Inglis JD, et al., Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991 Oct 15;106(2):213-20
(Latest) J:195889 Dev A, et al., Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins. J Exp Med. 2013 Feb 11;210(2):225-32
All references(30)
Other
accession IDs
MGD-MRK-32085, MGI:2144764

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory