Serpina3n
Gene Detail

Symbol Name ID

Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N MGI:105045

Synonyms

alpha-1 antiproteinase, antitrypsin, Spi2-2, Spi2.2, Spi2/eb.4

Feature Type

protein coding gene

Genetic Map

Chromosome 12

54.17 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:104406729-104414329 bp, + strand From VEGA annotation of GRCm38   7601 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:111129  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 6 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpina3n

Human homologs

Human Homolog		SERPINA3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Gene ID		12
neXtProt AC		NX_P01011
Human Synonyms		AACT, ACT, GIG25
Human Chr (Location)		14q32.1; chr14:95078714-95090390 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	acute-phase response, negative regulation of endopeptidase activity, ...
Component	extracellular region, extracellular space
Function	peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (75)    Tissues (24)    Images (27)
Theiler Stages: 17, 23

Assay Type	Results
RNA in situ	75

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) cDNA(63)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016315 (Evidence)
Ensembl Gene Model	ENSMUSG00000021091 (Evidence)
Entrez Gene	20716 (Evidence)
UniGene	482074
DFCI	TC1580665
DoTS	DT.55136724, DT.94207980
NIA Mouse Gene Index	U248018
PDB	1YXA
Consensus CDS Project	CCDS26152.1
International Mouse Knockout Project Status	Serpina3n

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016315	VEGA Gene Model | MGI Sequence Detail	7601	C57BL/6J
transcript	OTTMUST00000039207	VEGA | MGI Sequence Detail	2064	Not Applicable
polypeptide	OTTMUSP00000017513	VEGA | MGI Sequence Detail	418	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(222 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000015940	serine protease inhibitor A3N

References

(Earliest) J:698 Inglis JD, et al., Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991 Oct 15;106(2):213-20
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Other accession IDs

MGD-MRK-32084