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Serpina3n
Gene Detail
Symbol

Name
ID
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
MGI:105045
Synonyms
alpha-1 antiproteinase, antitrypsin, Spi2-2, Spi2.2, Spi2/eb.4
Feature Type
protein coding gene
Genetic Map
Chromosome 12
54.17 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:104406729-104414329 bp, + strand
From VEGA annotation of GRCm38

  7601 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111129  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 6 cattle; 1 dog

HCOP human homology predictions: SERPINA3
Protein SuperFamily: serpin
Gene Tree: Serpina3n

Human
homologs
SERPINA3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 12
neXtProt AC: NX_P01011

Human Synonyms: AACT, ACT, GIG24, GIG25

Human Chr (Location): 14q32.1; chr14:94612377-94624053 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Serpina3n interacts with 132 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (75)    Tissues (24)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) cDNA(64)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016315 (Evidence)
Ensembl Gene Model ENSMUSG00000021091 (Evidence)
Entrez Gene 20716 (Evidence)
UniGene 482074
DFCI TC1580665
DoTS DT.55136724, DT.94207980
NIA Mouse Gene Index U248018
PDB 1YXA
Consensus CDS Project CCDS26152.1
International Mouse Phenotyping Consortium Status Serpina3n
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016315 VEGA Gene Model | MGI Sequence Detail 7601 C57BL/6J ±  kb
transcript OTTMUST00000039207 VEGA | MGI Sequence Detail 2064 Not Applicable 
polypeptide OTTMUSP00000017513 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015940 serine protease inhibitor A3N
References
(Earliest) J:698 Inglis JD, et al., Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991 Oct 15;106(2):213-20
(Latest) J:220590 Vicuna L, et al., The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May;21(5):518-23
All references(33)
Other
accession IDs
MGD-MRK-32084

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory