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Serpina3n Gene Detail
Summary
  • Symbol
    Serpina3n
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3N
  • Synonyms
    alpha-1 antiproteinase, antitrypsin, Spi2-2, Spi2.2, Spi2/eb.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:105045
    NCBI Gene: 20716
  • Gene Overview
    MyGene.info: SERPINA3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104406729-104414329 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 54.17 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105045
protein coding gene Chr12:104406698-104414334 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020076
protein coding gene Chr12:106202008-106209632 (+)
A/J MGP_AJ_G0020030
protein coding gene Chr12:102167249-102174850 (+)
AKR/J MGP_AKRJ_G0020007
protein coding gene Chr12:105113370-105120980 (+)
BALB/cJ MGP_BALBcJ_G0020016
protein coding gene Chr12:102578464-102586073 (+)
C3H/HeJ MGP_C3HHeJ_G0019819
protein coding gene Chr12:105577723-105585323 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020462
protein coding gene Chr12:109509112-109516712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018075
protein coding gene Chr12:98878520-98886288 (+)
CAST/EiJ MGP_CASTEiJ_G0019360
protein coding gene Chr12:100389105-100397698 (+)
CBA/J MGP_CBAJ_G0019786
protein coding gene Chr12:113711666-113723572 (+)
DBA/2J MGP_DBA2J_G0019903
protein coding gene Chr12:101710864-101718473 (+)
FVB/NJ MGP_FVBNJ_G0019888
protein coding gene Chr12:100492674-100500319 (+)
LP/J MGP_LPJ_G0019978
protein coding gene Chr12:106066131-106077162 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019926
protein coding gene Chr12:117193305-117202558 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020491
protein coding gene Chr12:104543724-104551324 (+)
PWK/PhJ MGP_PWKPhJ_G0019123
protein coding gene Chr12:96219464-96227228 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018925
protein coding gene Chr12:98798521-98805081 (+)
WSB/EiJ MGP_WSBEiJ_G0019419
protein coding gene Chr12:105514513-105522122 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    15
  • Human Ortholog
    SERPINA3, serpin family A member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    neXtProt AC: NX_P01011
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612377-94624053 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021091 Ensembl Gene Model | MGI Sequence Detail 7601 C57BL/6J ±  kb
transcript ENSMUST00000021506 Ensembl | MGI Sequence Detail 2064 Not Applicable  
polypeptide ENSMUSP00000021506 Ensembl | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32084
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:698 Inglis JD, et al., Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991 Oct 15;106(2):213-20
  • Latest
    J:261995 Miyasaka Y, et al., CLICK: one-step generation of conditional knockout mice. BMC Genomics. 2018 May 2;19(1):318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory