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Ddx5
Gene Detail
Symbol

Name
ID
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
MGI:105037
Synonyms
2600009A06Rik, Hlr1, p68
Feature Type
protein coding gene
Genetic Map
Chromosome 11
70.01 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:106780355-106789185 bp, - strand
From VEGA annotation of GRCm38

  8831 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6797  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ATP-dependent RNA helicase
Gene Tree: Ddx5

Human
homologs
Human Homolog DDX5, DEAD (Asp-Glu-Ala-Asp) box helicase 5
NCBI Gene ID 1655
neXtProt AC  NX_P17844
Human Synonyms  G17P1, HLR1, HUMP68, p68
Human Chr (Location)  17q21; chr17:64498254-64506924 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(25) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter/null allele die around E11.5 displaying blood vessel malformations.
 
Interactions
Ddx5 interacts with 280 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process ATP catabolic process, circadian rhythm, ...
Component catalytic step 2 spliceosome, extracellular vesicular exosome, ...
Function androgen receptor binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (100)    Tissues (95)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Western blot 6
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000003589 (Evidence)
Ensembl Gene ModelENSMUSG00000020719 (Evidence)
Entrez Gene13207 (Evidence)
DFCITC1573667, TC1581161, TC1603390, TC1715680, TC1738626
DoTSDT.101197577, DT.101330974, DT.101330975, DT.102542733, DT.537622, DT.91440119, DT.94223651, DT.97339261, DT.97339273, DT.97389599
NIA Mouse Gene IndexU033549, U060853
EC3.6.4.13
Consensus CDS ProjectCCDS25562.1
International Mouse Knockout Project StatusDdx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003589 VEGA Gene Model | MGI Sequence Detail 8831 C57BL/6J ±  kb
transcript OTTMUST00000007731 VEGA | MGI Sequence Detail 3559 Not Applicable 
polypeptide OTTMUSP00000003751 VEGA | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(8) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)    SNPs within 2kb including multiple locations(19)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR012587 P68HR
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000629 RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000029396 ATP-dependent RNA helicase DDX5
References
(Earliest) J:9938 Iggo R, et al., Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6211-4
(Latest) J:199032 Jung C, et al., RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway. Biochim Biophys Acta. 2013 May;1833(5):1180-9
All references(64)
Other
accession IDs
MGD-MRK-16216, MGD-MRK-32076, MGI:1919368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory