Ddx5
Gene Detail

Symbol Name ID

Ddx5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 MGI:105037

Synonyms

2600009A06Rik, Hlr1, p68

Feature Type

protein coding gene

Genetic Map

Chromosome 11

70.01 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:106780355-106789185 bp, - strand From VEGA annotation of GRCm38   8831 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6797  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ATP-dependent RNA helicase
Gene Tree: Ddx5

Human homologs

Human Homolog		DDX5, DEAD (Asp-Glu-Ala-Asp) box helicase 5
NCBI Gene ID		1655
neXtProt AC		NX_P17844
Human Synonyms		G17P1, HLR1, HUMP68, p68
Human Chr (Location)		17q21; chr17:62494374-62502484 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(31) : Targeted(6) Gene trapped(25)
 

Mice homozygous for a reporter/null allele die around E11.5 displaying blood vessel malformations.

 

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	ATP catabolic process, circadian rhythm, ...
Component	catalytic step 2 spliceosome, nucleus, ...
Function	androgen receptor binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (100)    Tissues (95)    Images (16)
Theiler Stages: 15, 22, 28

Assay Type	Results
RNA in situ	94
Western blot	6

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000003589 (Evidence)
Ensembl Gene Model	ENSMUSG00000020719 (Evidence)
Entrez Gene	13207 (Evidence)
DFCI	TC1573667, TC1581161, TC1603390, TC1715680, TC1738626
DoTS	DT.101197577, DT.101330974, DT.101330975, DT.102542733, DT.537622, DT.91440119, DT.94223651, DT.97339261, DT.97339273, DT.97389599
NIA Mouse Gene Index	U033549, U060853
EC	3.6.4.13
Consensus CDS Project	CCDS25562.1
International Mouse Knockout Project Status	Ddx5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003589	VEGA Gene Model | MGI Sequence Detail	8831	C57BL/6J
transcript	OTTMUST00000007731	VEGA | MGI Sequence Detail	3559	Not Applicable
polypeptide	OTTMUSP00000003751	VEGA | MGI Sequence Detail	615	Not Applicable

All sequences(88) RefSeq(2) UniProt(11)

Polymorphisms

RFLP(1) : SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR012587	P68HR
InterPro	IPR000629	RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro	IPR014014	RNA helicase, DEAD-box type, Q motif
Protein Ontology	PR:000029396	ATP-dependent RNA helicase DDX5

References

(Earliest) J:9938 Iggo R, et al., Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6211-4
(Latest) J:191993 Lee J, et al., Scaling proprioceptor gene transcription by retrograde NT3 signaling. PLoS One. 2012;7(9):e45551
All references(62)

Other accession IDs

MGD-MRK-16216, MGD-MRK-32076, MGI:1919368