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Ddx5 Gene Detail
Summary
  • Symbol
    Ddx5
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
  • Synonyms
    2600009A06Rik, Hlr1, p68
  • Feature Type
    protein coding gene
  • IDs
    MGI:105037
    NCBI Gene: 13207
  • Gene Overview
    MyGene.info: DDX5
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106780355-106789180 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 70.01 cM, cytoband E2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105037
protein coding gene Chr11:106780355-106789185 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019313
protein coding gene Chr11:110115267-110126015 (-)
A/J MGP_AJ_G0019281
protein coding gene Chr11:105412400-105421990 (-)
AKR/J MGP_AKRJ_G0019250
protein coding gene Chr11:108555653-108564270 (-)
BALB/cJ MGP_BALBcJ_G0019255
protein coding gene Chr11:105827279-105838053 (-)
C3H/HeJ MGP_C3HHeJ_G0019064
protein coding gene Chr11:108850399-108859637 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019705
protein coding gene Chr11:113516131-113526730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017329
protein coding gene Chr11:102684730-102689858 (-)
CAST/EiJ MGP_CASTEiJ_G0018617
protein coding gene Chr11:109938909-109946931 (-)
CBA/J MGP_CBAJ_G0019033
protein coding gene Chr11:118219231-118228259 (-)
DBA/2J MGP_DBA2J_G0019145
protein coding gene Chr11:104881815-104891555 (-)
FVB/NJ MGP_FVBNJ_G0019136
protein coding gene Chr11:104397173-104405675 (-)
LP/J MGP_LPJ_G0019215
protein coding gene Chr11:110565127-110574075 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019166
protein coding gene Chr11:117459404-117470176 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019742
protein coding gene Chr11:109073737-109084042 (-)
PWK/PhJ MGP_PWKPhJ_G0018382
protein coding gene Chr11:105997818-106006910 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018173
protein coding gene Chr11:108847728-108857435 (-)
WSB/EiJ MGP_WSBEiJ_G0018668
protein coding gene Chr11:109050111-109059696 (-)



Homology
more
  • Human Ortholog
    DDX5, DEAD-box helicase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX5, DEAD-box helicase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G17P1, HLR1, HUMP68, p68
  • Links
    NCBI Gene ID: 1655
    neXtProt AC: NX_P17844
    UniProt: P17844

  • Chr Location
    17q23.3; chr17:64498254-64507038 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter/null allele die around E11.5 displaying blood vessel malformations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13207 NCBI Gene Model | MGI Sequence Detail 8826 C57BL/6J ±  kb
transcript NM_001355676 RefSeq | MGI Sequence Detail 3719 Not Specified  
polypeptide Q61656 UniProt | EBI | MGI Sequence Detail 614 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    12 Sequences
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
    IPR033488 RNA helicase p68 (DDX5)
    IPR012587 RNA helicase p68 repeat
Molecular
Reagents
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  • All nucleic 30
    cDNA 28
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-16216, MGD-MRK-32076, MGI:1919368
References
more
  • Summaries
    All 73
    Developmental Gene Expression 8
    Gene Ontology 16
    Phenotypes 12
  • Earliest
    J:9938 Iggo R, et al., Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6211-4
  • Latest
    J:260004 Moon BS, et al., Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis. Nat Commun. 2018 Jan 26;9(1):401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory