About   Help   FAQ
Gclm
Gene Detail
 Symbol
Name
ID
Gclm
glutamate-cysteine ligase, modifier subunit
MGI:104995
Synonyms Gcmc, Glclr
Feature Type protein coding gene
Genetic Map
Chromosome 3
52.94 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:122245557-122269984 bp, + strand
From VEGA annotation of GRCm38

  24428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gclm

Human
homologs
Human Homolog GCLM, glutamate-cysteine ligase, modifier subunit
NCBI Gene ID 2730
neXtProt AC  NX_P48507
Human Synonyms  GLCLR
Human Chr (Location)  1p22.1; chr1:93887034-93909598 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GCLM
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele demonstrate increased sensitivity to acetaminophen-induced hepatotoxicity and mice homozygous for another null allele exhibit increased cellular sensitivity to hydrogen peroxide.
 
Interactions
Gclm interacts with 358 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process apoptotic mitochondrial changes, cysteine metabolic process, ...
Component glutamate-cysteine ligase complex
Function glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (128)    Tissues (99)    Images (28)
Theiler Stages: 11, 22, 23, 24
Assay TypeResults
RNA in situ 118
Western blot 2
RT-PCR 8
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000021205 (Evidence)
Ensembl Gene ModelENSMUSG00000028124 (Evidence)
Entrez Gene14630 (Evidence)
DFCITC1579178, TC1628932, TC1635770, TC1651236
DoTSDT.101377670, DT.480923, DT.55214961, DT.94210442, DT.94293656
NIA Mouse Gene IndexU042479
Consensus CDS ProjectCCDS17808.1
International Mouse Knockout Project StatusGclm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021205 VEGA Gene Model | MGI Sequence Detail 24428 C57BL/6J ±  kb
transcript OTTMUST00000050234 VEGA | MGI Sequence Detail 4841 Not Applicable 
polypeptide OTTMUSP00000023426 VEGA | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000007898 glutamate--cysteine ligase regulatory subunit
References (Earliest) J:30588 Tsuchiya K, et al., Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995 Dec 10;30(3):630-2
(Latest) J:210286 Watanabe Y, et al., Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart. Cardiovasc Res. 2013 Feb 1;97(2):282-92
All references(70)
Other
accession IDs
MGD-MRK-31068, MGI:2139773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory