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Gclm
Gene Detail
Symbol

Name
ID
Gclm
glutamate-cysteine ligase, modifier subunit
MGI:104995
Synonyms
Gcmc, Glclr
Feature Type
protein coding gene
Genetic Map
Chromosome 3
52.94 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:122245557-122269984 bp, + strand
From VEGA annotation of GRCm38

  24428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GCLM
Gene Tree: Gclm

Human
homologs
GCLM, glutamate-cysteine ligase, modifier subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2730
neXtProt AC: NX_P48507

Human Synonyms: GLCLR

Human Chr (Location): 1p22.1; chr1:93885205-93909598 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GCLM

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele demonstrate increased sensitivity to acetaminophen-induced hepatotoxicity and mice homozygous for another null allele exhibit increased cellular sensitivity to hydrogen peroxide.
 
Interactions
Gclm interacts with 357 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (128)    Tissues (99)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
Western blot 2
RT-PCR 8
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gclm ; ZFIN gclm    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000021205 (Evidence)
Ensembl Gene Model ENSMUSG00000028124 (Evidence)
Entrez Gene 14630 (Evidence)
DFCI TC1651236, TC1635770, TC1628932, TC1579178
DoTS DT.55214961, DT.480923, DT.101377670, DT.94293656, DT.94210442
NIA Mouse Gene Index U042479
Consensus CDS Project CCDS17808.1
International Mouse Phenotyping Consortium Status Gclm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021205 VEGA Gene Model | MGI Sequence Detail 24428 C57BL/6J ±  kb
transcript OTTMUST00000050234 VEGA | MGI Sequence Detail 4841 Not Applicable 
polypeptide OTTMUSP00000023426 VEGA | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000007898 glutamate--cysteine ligase regulatory subunit
References
(Earliest) J:30588 Tsuchiya K, et al., Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995 Dec 10;30(3):630-2
(Latest) J:219963 Harris IS, et al., Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. 2015 Feb 9;27(2):211-22
All references(71)
Other
accession IDs
MGD-MRK-31068, MGI:2139773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory