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Gclm Gene Detail
Summary
  • Symbol
    Gclm
  • Name
    glutamate-cysteine ligase, modifier subunit
  • Synonyms
    Gcmc, Glclr
  • Feature Type
    protein coding gene
  • IDs
    MGI:104995
    NCBI Gene: 14630
  • Gene Overview
    MyGene.info: GCLM
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:122245557-122267215 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 52.94 cM, cytoband H1-3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104995
protein coding gene Chr3:122245557-122270732 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027837
protein coding gene Chr3:124497241-124520940 (+)
A/J MGP_AJ_G0027795
protein coding gene Chr3:120332054-120352237 (+)
AKR/J MGP_AKRJ_G0027761
protein coding gene Chr3:123399449-123420277 (+)
BALB/cJ MGP_BALBcJ_G0027807
protein coding gene Chr3:120140384-120161224 (+)
C3H/HeJ MGP_C3HHeJ_G0027538
protein coding gene Chr3:123794793-123817867 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028253
protein coding gene Chr3:129005047-129027430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025592
protein coding gene Chr3:115761542-115785798 (+)
CAST/EiJ MGP_CASTEiJ_G0026994
protein coding gene Chr3:123183581-123204198 (+)
CBA/J MGP_CBAJ_G0027513
protein coding gene Chr3:133393170-133418144 (+)
DBA/2J MGP_DBA2J_G0027654
protein coding gene Chr3:119472573-119492160 (+)
FVB/NJ MGP_FVBNJ_G0027622
protein coding gene Chr3:117081654-117101327 (+)
LP/J MGP_LPJ_G0027764
protein coding gene Chr3:126011095-126034260 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027652
protein coding gene Chr3:140953638-140975917 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028309
protein coding gene Chr3:122952916-122975208 (+)
PWK/PhJ MGP_PWKPhJ_G0026720
protein coding gene Chr3:119172643-119192645 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026543
protein coding gene Chr3:121050532-121074454 (+)
WSB/EiJ MGP_WSBEiJ_G0027074
protein coding gene Chr3:123683221-123703782 (+)



Homology
more
  • Human Ortholog
    GCLM, glutamate-cysteine ligase modifier subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GCLM, glutamate-cysteine ligase modifier subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLCLR
  • Links
    NCBI Gene ID: 2730
    neXtProt AC: NX_P48507
    UniProt: P48507

  • Chr Location
    1p22.1; chr1:93885199-93909598 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1557
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GCLM
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human GCLM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 5 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele demonstrate increased sensitivity to acetaminophen-induced hepatotoxicity and mice homozygous for another null allele exhibit increased cellular sensitivity to hydrogen peroxide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14630 NCBI Gene Model | MGI Sequence Detail 21659 C57BL/6J ±  kb
    transcript NM_008129 RefSeq | MGI Sequence Detail 2072 C57BL/6  
    polypeptide O09172 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007898 glutamate--cysteine ligase regulatory subunit
    • InterPro Domains
      IPR032963 Glutamate--cysteine ligase regulatory subunit
      IPR023210 NADP-dependent oxidoreductase domain
      IPR036812 NADP-dependent oxidoreductase domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-31068, MGI:2139773
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 45
    • Earliest
      J:30588 Tsuchiya K, et al., Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995 Dec 10;30(3):630-2
    • Latest
      J:262110 Killoy KM, et al., Decreased glutathione levels cause overt motor neuron degeneration in hSOD1(WT) over-expressing mice. Exp Neurol. 2018 Apr;302:129-135

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory