Gclm
Gene Detail

Symbol Name ID

Gclm glutamate-cysteine ligase, modifier subunit MGI:104995

Synonyms

Gcmc, Glclr

Feature Type

protein coding gene

Genetic Map

Chromosome 3

52.94 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:122245557-122269984 bp, + strand From VEGA annotation of GRCm38   24428 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gclm

Human homologs

Human Homolog		GCLM, glutamate-cysteine ligase, modifier subunit
NCBI Gene ID		2730
neXtProt AC		NX_P48507
Human Synonyms		GLCLR
Human Chr (Location)		1p22.1; chr1:94352590-94375012 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GCLM

Alleles and phenotypes

All alleles(16) : Targeted(4) Gene trapped(12)
 

Mice homozygous for one null allele demonstrate increased sensitivity to acetaminophen-induced hepatotoxicity and mice homozygous for another null allele exhibit increased cellular sensitivity to hydrogen peroxide.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cysteine metabolic process, glutamate metabolic process, ...
Component	glutamate-cysteine ligase complex
Function	glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (128)    Tissues (99)    Images (28)
Theiler Stages: 11, 22, 23, 24

Assay Type	Results
RNA in situ	118
Western blot	2
RT-PCR	8

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000021205 (Evidence)
Ensembl Gene Model	ENSMUSG00000028124 (Evidence)
Entrez Gene	14630 (Evidence)
DFCI	TC1579178, TC1628932, TC1635770, TC1651236
DoTS	DT.101377670, DT.480923, DT.55214961, DT.94210442, DT.94293656
NIA Mouse Gene Index	U042479
Consensus CDS Project	CCDS17808.1
International Mouse Knockout Project Status	Gclm

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021205	VEGA Gene Model | MGI Sequence Detail	24428	C57BL/6J
transcript	OTTMUST00000050234	VEGA | MGI Sequence Detail	4841	Not Applicable
polypeptide	OTTMUSP00000023426	VEGA | MGI Sequence Detail	274	Not Applicable

All sequences(55) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(197 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023210	NADP-dependent oxidoreductase domain
Protein Ontology	PR:000007898	glutamate--cysteine ligase regulatory subunit

References

(Earliest) J:30588 Tsuchiya K, et al., Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995 Dec 10;30(3):630-2
(Latest) J:194115 Lim J, et al., Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis. Cancer Res. 2013 Jan 15;73(2):908-17
All references(64)

Other accession IDs

MGD-MRK-31068, MGI:2139773