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Gclc
Gene Detail
 Symbol
Name
ID
Gclc
glutamate-cysteine ligase, catalytic subunit
MGI:104990
Synonyms D9Wsu168e, gamma GCS-HS, Glclc, GLCL-H
Feature Type protein coding gene
Genetic Map
Chromosome 9
43.36 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:77754535-77794485 bp, + strand
From VEGA annotation of GRCm38

  39951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamate-cysteine ligase heavy chain
Gene Tree: Gclc

Human
homologs
Human Homolog GCLC, glutamate-cysteine ligase, catalytic subunit
NCBI Gene ID 2729
neXtProt AC  NX_P48506
Human Synonyms  GCL, GCS, GLCL, GLCLC
Human Chr (Location)  6p12; chr6:53497341-53545129 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GCLC
Alleles
and
phenotypes
All alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are embryonic lethal. One model shows lethality before E13 while another shows lethality between E7.5-E8.5. In this second model, embryos are arrested at the egg cylinder stage, fail to gastrulate, do not form mesoderm, and exhibit increased apoptosis.
 
Human Diseases Modeled Using Mouse Gclc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process apoptotic mitochondrial changes, cell redox homeostasis, ...
Component cytosol, glutamate-cysteine ligase complex
Function ADP binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (323)    Tissues (168)    Images (36)
Theiler Stages: 2, 3, 4, 11, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 287
Northern blot 7
Western blot 5
RT-PCR 24
cDNA source data(119)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(128) Genomic(1) cDNA(121) Primer pair(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021059 (Evidence)
Ensembl Gene ModelENSMUSG00000032350 (Evidence)
Entrez Gene14629 (Evidence)
UniGene89888
DFCITC1577469, TC1620163, TC1622806
DoTSDT.101280769, DT.110603184, DT.536059
NIA Mouse Gene IndexU010769
EC6.3.2.2
Consensus CDS ProjectCCDS23354.1
International Mouse Knockout Project StatusGclc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021059 VEGA Gene Model | MGI Sequence Detail 39951 C57BL/6J ±  kb
transcript OTTMUST00000049815 VEGA | MGI Sequence Detail 3423 Not Applicable 
polypeptide OTTMUSP00000023141 VEGA | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(7) UniProt(3)
Polymorphisms SNPs within 2kb(347 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004308 Glutamate-cysteine ligase catalytic subunit
Protein Ontology PR:000007897 glutamate--cysteine ligase catalytic subunit
References (Earliest) J:29012 Harvey MB, et al., Expression of genes encoding antioxidant enzymes in preimplantation mouse and cow embryos and primary bovine oviduct cultures employed for embryo coculture. Biol Reprod. 1995 Sep;53(3):532-40
(Latest) J:197430 Cabungcal JH, et al., Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9130-5
All references(66)
Other
accession IDs
MGD-MRK-31063, MGD-MRK-36456, MGI:107879

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory