Gclc
Gene Detail

Symbol Name ID

Gclc glutamate-cysteine ligase, catalytic subunit MGI:104990

Synonyms

D9Wsu168e, gamma GCS-HS, Glclc, GLCL-H

Feature Type

protein coding gene

Genetic Map

Chromosome 9

43.36 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:77754535-77794485 bp, + strand From VEGA annotation of GRCm38   39951 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamate-cysteine ligase heavy chain
Gene Tree: Gclc

Human homologs

Human Homolog		GCLC, glutamate-cysteine ligase, catalytic subunit
NCBI Gene ID		2729
neXtProt AC		NX_P48506
Human Synonyms		GCL, GCS, GLCL, GLCLC
Human Chr (Location)		6p12; chr6:53362139-53409927 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GCLC

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(4)
 

Homozygous mutant mice are embryonic lethal. One model shows lethality before E13 while another shows lethality between E7.5-E8.5. In this second model, embryos are arrested at the egg cylinder stage, fail to gastrulate, do not form mesoderm, and exhibit increased apoptosis.

 
Human Diseases Modeled Using Mouse Gclc (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	cell redox homeostasis, cysteine metabolic process, ...
Component	cytosol, glutamate-cysteine ligase complex
Function	ADP binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (285)    Tissues (130)    Images (34)
Theiler Stages: 2, 3, 4, 11, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	249
Northern blot	7
Western blot	5
RT-PCR	24

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(16) Primer pair(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021059 (Evidence)
Ensembl Gene Model	ENSMUSG00000032350 (Evidence)
Entrez Gene	14629 (Evidence)
DFCI	TC1577469, TC1620163, TC1622806
DoTS	DT.101280769, DT.110603184, DT.536059
NIA Mouse Gene Index	U010769
EC	6.3.2.2
Consensus CDS Project	CCDS23354.1
International Mouse Knockout Project Status	Gclc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021059	VEGA Gene Model | MGI Sequence Detail	39951	C57BL/6J
transcript	OTTMUST00000049815	VEGA | MGI Sequence Detail	3423	Not Applicable
polypeptide	OTTMUSP00000023141	VEGA | MGI Sequence Detail	637	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(219 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004308	Glutamate-cysteine ligase catalytic subunit
Protein Ontology	PR:000007897	glutamate--cysteine ligase catalytic subunit

References

(Earliest) J:29012 Harvey MB, et al., Expression of genes encoding antioxidant enzymes in preimplantation mouse and cow embryos and primary bovine oviduct cultures employed for embryo coculture. Biol Reprod. 1995 Sep;53(3):532-40
(Latest) J:194778 Fan X, et al., The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis. PLoS One. 2012;7(11):e50832
All references(62)

Other accession IDs

MGD-MRK-31063, MGD-MRK-36456, MGI:107879