About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gclc
glutamate-cysteine ligase, catalytic subunit
MGI:104990
27 phenotypes from 4 alleles in 5 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Gclctm1c(EUCOMM)Wtsi/Gclc+
Tg(Cryaa-cre)10Mlr/0
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		oxidative stress J:194778
Gclctm1c(EUCOMM)Wtsi/Gclctm1c(EUCOMM)Wtsi
Tg(Cryaa-cre)10Mlr/0
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		cataract J:194778
nuclear cataract J:194778
oxidative stress J:194778
Gclctm1Dwn/Gclc+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal liver physiology J:66499
Gclctm1Dwn/Gclctm1Dwn
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality, complete penetrance J:66499
Gclctm1Mwl/Gclc+
involves: 129S7/SvEvBrd * C57BL/6 		no abnormal phenotype detected J:62177
Gclctm1Mwl/Gclctm1Mwl
involves: 129S7/SvEvBrd * C57BL/6 		abnormal embryo development J:62177
abnormal embryonic-extraembryonic boundary morphology J:62177
absent mesoderm J:62177
decreased cell proliferation J:62177
embryonic growth arrest J:62177
embryonic growth retardation J:62177
embryonic lethality between implantation and somite formation, complete penetrance J:62177
failure to gastrulate J:62177
increased embryonic tissue cell apoptosis J:62177
Gclctm1Tdal/Gclctm1Tdal
Pvalbtm1(cre)Arbr/Pvalb+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal cingulate gyrus morphology J:197430
Gclctm1Tdal/Gclctm1Tdal
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA 		abnormal endoplasmic reticulum morphology J:202376
abnormal homeostasis J:202376
abnormal liver morphology J:202376
abnormal mitochondrial morphology J:202376
abnormal mitochondrial physiology J:202376
decreased mitochondrial number J:202376
hepatic steatosis J:202376
increased circulating alanine transaminase level J:202376
increased circulating aspartate transaminase level J:202376
postnatal growth retardation J:202376
premature death J:202376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory