Gclc^tm1Tdal
Targeted Allele Detail

Summary

• Symbol: Gclc^tm1Tdal
• Name: glutamate-cysteine ligase, catalytic subunit; targeted mutation 1, Timothy P Dalton
• MGI ID: MGI:5518957
• Synonyms: Gclc^f
• Gene: Gclc Location: Chr9:77661817-77701767 bp, + strand Genetic Position: Chr9, 43.36 cM, cytoband D-E
• Alliance: Gclc^tm1Tdal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene was inserted in intron 3 and a third loxP site was inserted in intron 6 . Exons 4 to 6 are thus flanked by loxP sites. (J:202376)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gclc Mutation: 19 strains or lines available

References

• Original: J:202376 Chen Y, et al., Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology. 2007 May;45(5):1118-28
• All: 7 reference(s)