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Ptk2b Gene Detail
Summary
  • Symbol
    Ptk2b
  • Name
    PTK2 protein tyrosine kinase 2 beta
  • Synonyms
    CAKbeta, calcium-dependent tyrosine kinase, cellular adhesion kinase beta, E430023O05Rik, proline-rich tyrosine kinase 2, PYK2, Raftk, related adhesion focal tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:104908
    NCBI Gene: 19229
  • Gene Overview
    MyGene.info: PTK2B
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66153257-66281052 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104908
protein coding gene Chr14:66153257-66281068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021493
protein coding gene Chr14:60810929-60950653 (-)
A/J MGP_AJ_G0021452
protein coding gene Chr14:59379199-59503229 (-)
AKR/J MGP_AKRJ_G0021428
protein coding gene Chr14:61443078-61576534 (-)
BALB/cJ MGP_BALBcJ_G0021458
protein coding gene Chr14:59332245-59469255 (-)
C3H/HeJ MGP_C3HHeJ_G0021235
protein coding gene Chr14:61121621-61259152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021897
protein coding gene Chr14:63605337-63761934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019437
protein coding gene Chr14:57309444-57434721 (-)
CAST/EiJ MGP_CASTEiJ_G0020752
protein coding gene Chr14:57601343-57733666 (-)
CBA/J MGP_CBAJ_G0021202
protein coding gene Chr14:65544530-65697236 (-)
DBA/2J MGP_DBA2J_G0021325
protein coding gene Chr14:59027416-59157046 (-)
FVB/NJ MGP_FVBNJ_G0021304
protein coding gene Chr14:58437278-58568010 (-)
LP/J MGP_LPJ_G0021400
protein coding gene Chr14:61854991-61997117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021333
protein coding gene Chr14:64619395-64749787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021920
protein coding gene Chr14:60636924-60773820 (-)
PWK/PhJ MGP_PWKPhJ_G0020496
protein coding gene Chr14:55759020-55889847 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020329
protein coding gene Chr14:56604783-56734956 (-)
WSB/EiJ MGP_WSBEiJ_G0020805
protein coding gene Chr14:60942524-61074870 (-)



Homology
more
  • Human Ortholog
    PTK2B, protein tyrosine kinase 2 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTK2B, protein tyrosine kinase 2 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
  • Links
    NCBI Gene ID: 2185
    neXtProt AC: NX_Q14289
    UniProt: Q14289

  • Chr Location
    8p21.2; chr8:27311482-27459391 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059456 Ensembl Gene Model | MGI Sequence Detail 127796 C57BL/6J ±  kb
transcript ENSMUST00000022622 Ensembl | MGI Sequence Detail 4034 Not Applicable  
polypeptide ENSMUSP00000022622 Ensembl | MGI Sequence Detail 1009 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 51
    Genomic 2
    cDNA 47
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-29062, MGI:2444305
References
more
  • Summaries
    All 111
    Developmental Gene Expression 7
    Gene Ontology 20
    Phenotypes 31
  • Earliest
    J:29773 Avraham S, et al., Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 1995 Nov 17;270(46):27742-51
  • Latest
    J:265937 Posritong S, et al., Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene. Mol Cell Endocrinol. 2018 Oct 15;474:35-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory