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Ptk2b Gene Detail
Summary
  • Symbol
    Ptk2b
  • Name
    PTK2 protein tyrosine kinase 2 beta
  • Synonyms
    CAKbeta, calcium-dependent tyrosine kinase, cellular adhesion kinase beta, E430023O05Rik, proline-rich tyrosine kinase 2, PYK2, Raftk, related adhesion focal tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:104908
    NCBI Gene: 19229
  • Gene Overview
    MyGene.info: PTK2B
Location & Maps
more
  • Sequence Map
    Chr14:66153257-66281052 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      127796 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PTK2B, protein tyrosine kinase 2 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTK2B, protein tyrosine kinase 2 beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
  • Links
    NCBI Gene ID: 2185
    neXtProt AC: NX_Q14289

  • Chr Location
    8p21.1; chr8:27311482-27459391 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    3
  • Genomic Mutations
    1 involving Ptk2b
  • Incidental Mutations
Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016348 VEGA Gene Model | MGI Sequence Detail 127796 C57BL/6J ±  kb
transcript OTTMUST00000039303 VEGA | MGI Sequence Detail 4034 Not Applicable  
polypeptide OTTMUSP00000017565 VEGA | MGI Sequence Detail 1009 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    759 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 50
    Genomic 1
    cDNA 47
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-29062, MGI:2444305
References
more
  • Summaries
    All 84
    Developmental Gene Expression 6
    Gene Ontology 18
    Phenotypes 24
  • Earliest
    J:29773 Avraham S, et al., Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 1995 Nov 17;270(46):27742-51
  • Latest
    J:231935 Jabara HH, et al., A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016 Jan;48(1):74-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory