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Ptk2b
Gene Detail
 Symbol
Name
ID
Ptk2b
PTK2 protein tyrosine kinase 2 beta
MGI:104908
Synonyms CAKbeta, calcium-dependent tyrosine kinase, cellular adhesion kinase beta, E430023O05Rik, proline-rich tyrosine kinase 2, PYK2, Raftk, related adhesion focal tyrosine kinase
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:66153257-66281052 bp, - strand
From VEGA annotation of GRCm38

  127796 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: focal adhesion kinase 1/2
Gene Tree: Ptk2b

Human
homologs
Human Homolog PTK2B, protein tyrosine kinase 2 beta
NCBI Gene ID 2185
neXtProt AC  NX_Q14289
Human Synonyms  CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
Human Chr (Location)  8p21.1; chr8:27311482-27459391 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function.
 
Interactions
Ptk2b interacts with 142 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (128 annotations)
Process actin filament organization, activation of Janus kinase activity, ...
Component apical dendrite, axon, ...
Function 3-phosphoinositide-dependent protein kinase binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (38)    Tissues (16)    Images (15)
Theiler Stages: 13, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 10
Western blot 4
RT-PCR 19
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(1) cDNA(47) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016348 (Evidence)
Ensembl Gene ModelENSMUSG00000059456 (Evidence)
Entrez Gene19229 (Evidence)
UniGene21613
DFCITC1576336, TC1595312, TC1609069, TC1619066
DoTSDT.101174825, DT.101331769, DT.490528, DT.91326156, DT.94369892
NIA Mouse Gene IndexU035701
EC2.7.10.2
Consensus CDS ProjectCCDS27220.1, CCDS49525.1, CCDS49526.1
International Mouse Knockout Project StatusPtk2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016348 VEGA Gene Model | MGI Sequence Detail 127796 C57BL/6J ±  kb
transcript OTTMUST00000039303 VEGA | MGI Sequence Detail 4034 Not Applicable 
polypeptide OTTMUSP00000017565 VEGA | MGI Sequence Detail 1009 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(18) UniProt(9)
Polymorphisms SNPs within 2kb(767 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR005189 Focal adhesion kinase, targeting (FAT) domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003032 focal adhesion kinase 2
References (Earliest) J:29773 Avraham S, et al., Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 1995 Nov 17;270(46):27742-51
(Latest) J:211002 Koppel AC, et al., Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice. Am J Physiol Cell Physiol. 2014 May 15;306(10):C899-909
All references(81)
Other
accession IDs
MGD-MRK-29062, MGI:2444305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory