Gpc3
Gene Detail

Symbol Name ID

Gpc3 glypican 3 MGI:104903

Synonyms

OCI-5

Feature Type

protein coding gene

Genetic Map

Chromosome X

28.74 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:52272426-52613950 bp, - strand From VEGA annotation of GRCm38   341525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glypican
Gene Tree: Gpc3

Human homologs

Human Homolog		GPC3, glypican 3
NCBI Gene ID		2719
neXtProt AC		NX_P51654
Human Synonyms		DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1
Human Chr (Location)		Xq26.1; chrX:132669773-133119673 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GPC3

Alleles and phenotypes

All alleles(34) : Targeted(5) Gene trapped(29)
 

A gene trap mutation exibits neonatal lethality, embryonic overgrowth and kidney cysts.

 
Human Diseases Modeled Using Mouse Gpc3 (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	anterior/posterior axis specification, body morphogenesis, ...
Component	anchored to membrane, anchored to plasma membrane, ...
Function	heparan sulfate proteoglycan binding, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (250)    Tissues (71)    Images (34)
Theiler Stages: 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 25

Assay Type	Results
RNA in situ	247
RT-PCR	3

cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(134) cDNA(131) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017333 (Evidence)
Ensembl Gene Model	ENSMUSG00000055653 (Evidence)
Entrez Gene	14734 (Evidence)
UniGene	22515
DFCI	TC1572110, TC1655557
DoTS	DT.101176600, DT.87072725
NIA Mouse Gene Index	U039382
Consensus CDS Project	CCDS30125.1
International Mouse Knockout Project Status	Gpc3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017333	VEGA Gene Model | MGI Sequence Detail	341525	C57BL/6J
transcript	OTTMUST00000042115	VEGA | MGI Sequence Detail	2216	Not Applicable
polypeptide	OTTMUSP00000018969	VEGA | MGI Sequence Detail	579	Not Applicable

All sequences(36) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(1694 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001863	Glypican
InterPro	IPR015501	Glypican-3
InterPro	IPR019803	Glypican, conserved site
Protein Ontology	PR:000008165	glypican-3

References

(Earliest) J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
(Latest) J:195867 Khurana S, et al., Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance. Blood. 2013 Apr 4;121(14):2587-95
All references(64)

Other accession IDs

MGD-MRK-29057