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Gpc3
Gene Detail
 Symbol
Name
ID
Gpc3
glypican 3
MGI:104903
Synonyms OCI-5
Feature Type protein coding gene
Genetic Map
Chromosome X
28.74 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:52272426-52613950 bp, - strand
From VEGA annotation of GRCm38

  341525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glypican
Gene Tree: Gpc3

Human
homologs
Human Homolog GPC3, glypican 3
NCBI Gene ID 2719
neXtProt AC  NX_P51654
Human Synonyms  DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1
Human Chr (Location)  Xq26.1; chrX:133535745-133985646 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GPC3
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(29) Targeted(5)
 
A gene trap mutation exibits neonatal lethality, embryonic overgrowth and kidney cysts.
 
Human Diseases Modeled Using Mouse Gpc3 (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(4)
Interactions
Gpc3 interacts with 118 markers (Mir1b, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process anterior/posterior axis specification, body morphogenesis, ...
Component anchored component of membrane, anchored component of plasma membrane, ...
Function heparan sulfate proteoglycan binding, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (264)    Tissues (77)    Images (42)
Theiler Stages: 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26
Assay TypeResults
RNA in situ 261
RT-PCR 3
cDNA source data(131)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(135) cDNA(132) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017333 (Evidence)
Ensembl Gene ModelENSMUSG00000055653 (Evidence)
Entrez Gene14734 (Evidence)
UniGene22515
DFCITC1572110, TC1655557
DoTSDT.101176600, DT.87072725
NIA Mouse Gene IndexU039382
Consensus CDS ProjectCCDS30125.1
International Mouse Knockout Project StatusGpc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017333 VEGA Gene Model | MGI Sequence Detail 341525 C57BL/6J ±  kb
transcript OTTMUST00000042115 VEGA | MGI Sequence Detail 2216 Not Applicable 
polypeptide OTTMUSP00000018969 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(1723 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001863 Glypican
InterPro IPR015501 Glypican-3
InterPro IPR019803 Glypican, conserved site
Protein Ontology PR:000008165 glypican-3
References (Earliest) J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
(Latest) J:201656 de Wit J, et al., Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. Neuron. 2013 Aug 21;79(4):696-711
All references(67)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-29057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory