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Gpc3
Gene Detail
Symbol

Name
ID
Gpc3
glypican 3
MGI:104903
Synonyms
OCI-5
Feature Type
protein coding gene
Genetic Map
Chromosome X
28.74 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:52272426-52613950 bp, - strand
From VEGA annotation of GRCm38

  341525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPC3
Protein SuperFamily: glypican
Gene Tree: Gpc3

Human
homologs
GPC3, glypican 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2719
neXtProt AC: NX_P51654

Human Synonyms: DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1

Human Chr (Location): Xq26.1; chrX:133535745-133985646 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GPC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(29) Targeted(5)
 
A gene trap mutation exibits neonatal lethality, embryonic overgrowth and kidney cysts.
 
Human Diseases Modeled in Mice Using Gpc3 (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Gpc3 interacts with 117 markers (Mir1b, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (23 records)
Data Summary: Results (264)    Tissues (77)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 261
RT-PCR 3
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GPC3 ; Xenbase gpc3 ; ZFIN gpc3    NEW 
Molecular
reagents
All nucleic(135) cDNA(132) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017333 (Evidence)
Ensembl Gene Model ENSMUSG00000055653 (Evidence)
Entrez Gene 14734 (Evidence)
UniGene 22515
DFCI TC1572110, TC1655557
DoTS DT.101176600, DT.87072725
NIA Mouse Gene Index U039382
Consensus CDS Project CCDS30125.1
International Mouse Phenotyping Consortium Status Gpc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017333 VEGA Gene Model | MGI Sequence Detail 341525 C57BL/6J ±  kb
transcript OTTMUST00000042115 VEGA | MGI Sequence Detail 2216 Not Applicable 
polypeptide OTTMUSP00000018969 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(1723 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001863 Glypican
InterPro IPR015501 Glypican-3
InterPro IPR019803 Glypican, conserved site
Protein Ontology PR:000008165 glypican-3
References
(Earliest) J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
(Latest) J:221247 Zhang T, et al., Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer. PLoS One. 2015;10(3):e0118448
All references(70)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-29057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory