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Symbol
Name
ID

Gpc3
glypican 3
MGI:104903

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Trigonocephaly

Mandibular prognathia

Dandy-Walker malformation

Macrocephaly

Metopic synostosis

Short neck

Short 2nd finger

Clinodactyly of the 5th finger

Postaxial hand polydactyly

Short distal phalanx of finger

Camptodactyly of finger

Broad thumb

Short finger

Short toe

Broad toe

Toe syndactyly

Postaxial polydactyly

Finger syndactyly

2-3 finger syndactyly

Short foot

Short palm

Congenital hip dislocation

Two carpal ossification centers present at birth

Vertebral fusion

Accelerated skeletal maturation

Narrow greater sciatic notch

Short greater sciatic notch

Flared iliac wing

Abnormal rib morphology

Short ribs

Cervical ribs

Short sternum

Pectus carinatum

Pectus excavatum

Scoliosis

Six lumbar vertebrae

Vertebral segmentation defect

Disease(s) Associated with GPC3

Simpson-Golabi-Behmel syndrome type 1

Mouse Phenotypes		abnormal osteoclast differentiation	absent mandible	mandible hypoplasia	asymmetric sternocostal joints	split xiphoid process	abnormal endochondral bone ossification
Availability	Mouse Genotype	abnormal osteoclast differentiation	absent mandible	mandible hypoplasia	asymmetric sternocostal joints	split xiphoid process	abnormal endochondral bone ossification
	Gpc3^tm1Fil/Gpc3^tm1Fil
	Gpc3^Gt(Ex136)Byg/Gpc3⁺
	Gpc3^tm1Snd/Gpc3⁺
	Gpc3^Gt(Ex136)Byg/Y
	Gpc3^tm1Arge/Y
	Gpc3^tm1Fil/Y
	Gpc3^tm1Snd/Y

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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