About   Help   FAQ
Ltbr
Gene Detail
Symbol

Name
ID
Ltbr
lymphotoxin B receptor
MGI:104875
Synonyms
Ltar, LTbetaR, LT beta-R, LT-beta receptor, Tnfbr, TNFCR, TNFR2-RP, TNF receptor-related protein, TNF-R-III, TNFRrp, Tnfrsf3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:125306571-125313885 bp, - strand
From VEGA annotation of GRCm38

  7315 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LTBR
Protein SuperFamily: tumor necrosis factor receptor superfamily member 3
Gene Tree: Ltbr

Human
homologs
LTBR, lymphotoxin beta receptor (TNFR superfamily, member 3)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4055
neXtProt AC: NX_P36941

Human Synonyms: CD18, D12S370, LT-BETA-R, TNFCR, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3

Human Chr (Location): 12p13; chr12:6375368-6391571 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation lack Peyer's patches, colon-associated lymphoid tissues, and lymph nodes. Mutants also exhibit severely reduced numbers of NK cells and increased susceptibility to Theiler's murine encephalomyelitis virus.
 
Interactions
Ltbr interacts with 74 markers (Mir18, Mir18b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process apoptotic process, lymph node development, ...
Component integral component of membrane, membrane
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (152)    Tissues (60)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 87
Northern blot 16
RT-PCR 49
cDNA source data(103)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) Genomic(5) cDNA(103) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034580 (Evidence)
Ensembl Gene Model ENSMUSG00000030339 (Evidence)
Entrez Gene 17000 (Evidence)
UniGene 3122
DFCI TC1576203
DoTS DT.94306708
NIA Mouse Gene Index U027868
Consensus CDS Project CCDS20549.1
International Mouse Phenotyping Consortium Status Ltbr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034580 VEGA Gene Model | MGI Sequence Detail 7315 C57BL/6J ±  kb
transcript OTTMUST00000087730 VEGA | MGI Sequence Detail 2107 Not Applicable 
polypeptide OTTMUSP00000047757 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(3) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR017349 Tumour necrosis factor receptor 3
Protein Ontology PR:000009976 tumor necrosis factor receptor superfamily member 3
References
(Earliest) J:18011 de Kossodo S, et al., Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. Infect Immun. 1994 Apr;62(4):1414-20
(Latest) J:219573 Van Praet JT, et al., Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015 Feb 12;34(4):466-74
All references(154)
Other
accession IDs
MGD-MRK-19752, MGD-MRK-28148, MGD-MRK-28175, MGI:104851, MGI:2141385, MGI:893576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory