Ltbr
Gene Detail

Symbol Name ID

Ltbr lymphotoxin B receptor MGI:104875

Synonyms

Ltar, LTbetaR, LT beta-R, LT-beta receptor, Tnfbr, TNFCR, TNFR2-RP, TNF receptor-related protein, TNF-R-III, TNFRrp, Tnfrsf3

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr6:125306571-125313885 bp, - strand From VEGA annotation of GRCm38   7315 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor receptor superfamily member 3
Gene Tree: Ltbr

Human homologs

Human Homolog		LTBR, lymphotoxin beta receptor (TNFR superfamily, member 3)
NCBI Gene ID		4055
neXtProt AC		NX_P36941
Human Synonyms		CD18, D12S370, LT-BETA-R, TNFCR, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3
Human Chr (Location)		12p13; chr12:6484534-6500737 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for a targeted null mutation lack Peyer's patches, colon-associated lymphoid tissues, and lymph nodes. Mutants also exhibit severely reduced numbers of NK cells and increased susceptibility to Theiler's murine encephalomyelitis virus.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	apoptotic process, lymph node development, ...
Component	integral to membrane, membrane
Function	identical protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (152)    Tissues (60)    Images (25)
Theiler Stages: 10, 17, 18, 23, 25, 28

Assay Type	Results
RNA in situ	87
Northern blot	16
RT-PCR	49

cDNA source data(101)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(109) Genomic(5) cDNA(101) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034580 (Evidence)
Ensembl Gene Model	ENSMUSG00000030339 (Evidence)
Entrez Gene	17000 (Evidence)
UniGene	3122
DFCI	TC1576203
DoTS	DT.94306708
NIA Mouse Gene Index	U027868
Consensus CDS Project	CCDS20549.1
International Mouse Knockout Project Status	Ltbr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034580	VEGA Gene Model | MGI Sequence Detail	7315	C57BL/6J
transcript	OTTMUST00000087730	VEGA | MGI Sequence Detail	2107	Not Applicable
polypeptide	OTTMUSP00000047757	VEGA | MGI Sequence Detail	415	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(3) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR017349	Tumour necrosis factor receptor 3
Protein Ontology	PR:000009976	tumor necrosis factor receptor superfamily member 3

References

(Earliest) J:18011 de Kossodo S, et al., Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. Infect Immun. 1994 Apr;62(4):1414-20
(Latest) J:193490 Van Den Broeck T, et al., Differential Ly49e Expression Pathways in Resting versus TCR-Activated Intraepithelial gammadelta T Cells. J Immunol. 2013 Mar 1;190(5):1982-90
All references(142)

Other accession IDs

MGD-MRK-19752, MGD-MRK-28148, MGD-MRK-28175, MGI:104851, MGI:2141385, MGI:893576