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Ltbr
Gene Detail
 Symbol
Name
ID
Ltbr
lymphotoxin B receptor
MGI:104875
Synonyms Ltar, LTbetaR, LT beta-R, LT-beta receptor, Tnfbr, TNFCR, TNFR2-RP, TNF receptor-related protein, TNF-R-III, TNFRrp, Tnfrsf3
Feature Type protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:125306571-125313885 bp, - strand
From VEGA annotation of GRCm38

  7315 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor receptor superfamily member 3
Gene Tree: Ltbr

Human
homologs
Human Homolog LTBR, lymphotoxin beta receptor (TNFR superfamily, member 3)
NCBI Gene ID 4055
neXtProt AC  NX_P36941
Human Synonyms  CD18, D12S370, LT-BETA-R, TNFCR, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3
Human Chr (Location)  12p13; chr12:6375368-6391571 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation lack Peyer's patches, colon-associated lymphoid tissues, and lymph nodes. Mutants also exhibit severely reduced numbers of NK cells and increased susceptibility to Theiler's murine encephalomyelitis virus.
 
Interactions
Ltbr interacts with 75 markers (Mir18, Mir18b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process apoptotic process, lymph node development, ...
Component integral component of membrane, membrane
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (152)    Tissues (60)    Images (25)
Theiler Stages: 10, 17, 18, 23, 25, 28
Assay TypeResults
RNA in situ 87
Northern blot 16
RT-PCR 49
cDNA source data(103)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) Genomic(5) cDNA(103) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034580 (Evidence)
Ensembl Gene ModelENSMUSG00000030339 (Evidence)
Entrez Gene17000 (Evidence)
UniGene3122
DFCITC1576203
DoTSDT.94306708
NIA Mouse Gene IndexU027868
Consensus CDS ProjectCCDS20549.1
International Mouse Knockout Project StatusLtbr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034580 VEGA Gene Model | MGI Sequence Detail 7315 C57BL/6J ±  kb
transcript OTTMUST00000087730 VEGA | MGI Sequence Detail 2107 Not Applicable 
polypeptide OTTMUSP00000047757 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR017349 Tumour necrosis factor receptor 3
Protein Ontology PR:000009976 tumor necrosis factor receptor superfamily member 3
References (Earliest) J:18011 de Kossodo S, et al., Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. Infect Immun. 1994 Apr;62(4):1414-20
(Latest) J:207324 Williams JA, et al., Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol. 2014 Jan 15;192(2):630-40
All references(151)
Other
accession IDs
MGD-MRK-19752, MGD-MRK-28148, MGD-MRK-28175, MGI:104851, MGI:2141385, MGI:893576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory