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Ltbr Gene Detail
Summary
  • Symbol
    Ltbr
  • Name
    lymphotoxin B receptor
  • Synonyms
    Ltar, LTbetaR, LT beta-R, LT-beta receptor, Tnfbr, TNFCR, TNFR2-RP, TNF receptor-related protein, TNF-R-III, TNFRrp, Tnfrsf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104875
    NCBI Gene: 17000
  • Gene Overview
    MyGene.info: LTBR
Location & Maps
more
  • Sequence Map
    Chr6:125306571-125313885 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7315 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    LTBR, lymphotoxin beta receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LTBR, lymphotoxin beta receptor
    Orthology source: HomoloGene
  • Synonyms
    CD18, D12S370, LT-BETA-R, TNFCR, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3
  • Links
    NCBI Gene ID: 4055
    neXtProt AC: NX_P36941

  • Chr Location
    12p13; chr12:6375368-6391571 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Targeted
    6
  • Incidental Mutations
Homozygotes for a targeted null mutation lack Peyer's patches, colon-associated lymphoid tissues, and lymph nodes. Mutants also exhibit severely reduced numbers of NK cells and increased susceptibility to Theiler's murine encephalomyelitis virus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034580 VEGA Gene Model | MGI Sequence Detail 7315 C57BL/6J ±  kb
transcript OTTMUST00000087730 VEGA | MGI Sequence Detail 2107 Not Applicable  
polypeptide OTTMUSP00000047757 VEGA | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009976 tumor necrosis factor receptor superfamily member 3
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR017349 Tumour necrosis factor receptor 3
Molecular
Reagents
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  • All nucleic 111
    Genomic 5
    cDNA 103
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19752, MGD-MRK-28148, MGD-MRK-28175, MGI:104851, MGI:2141385, MGI:893576
References
more
  • Summaries
    All 158
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 97
  • Earliest
    J:18011 de Kossodo S, et al., Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. Infect Immun. 1994 Apr;62(4):1414-20
  • Latest
    J:231765 Tang H, et al., Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade. Cancer Cell. 2016 Mar 14;29(3):285-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory