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Akt2
Gene Detail
 Symbol
Name
ID
Akt2
thymoma viral proto-oncogene 2
MGI:104874
Synonyms 2410016A19Rik, PKB, PKBbeta
Feature Type protein coding gene
Genetic Map
Chromosome 7
15.94 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:27591552-27640826 bp, + strand
From VEGA annotation of GRCm38

  49275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt2

Human
homologs
Human Homolog AKT2, v-akt murine thymoma viral oncogene homolog 2
NCBI Gene ID 208
neXtProt AC  NX_P31751
Human Synonyms  HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Human Chr (Location)  19q13.1-q13.2; chr19:40230317-40285536 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human AKT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(48) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit insulin resistance and elevated plasma triglycerides. In males, the insulin resistance may progress to overt diabetes.
 
Human Diseases Modeled Using Mouse Akt2 (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Akt2 interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process activation of Ral GTPase activity, apoptotic process, ...
Component cell cortex, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (97)    Tissues (57)    Images (21)
Theiler Stages: 2, 19, 23, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 67
Western blot 27
RT-PCR 2
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016504 (Evidence)
Ensembl Gene ModelENSMUSG00000004056 (Evidence)
Entrez Gene11652 (Evidence)
NIA Mouse Gene IndexU007859, U028304
EC2.7.11.1
Consensus CDS ProjectCCDS21027.1
International Mouse Knockout Project StatusAkt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016504 VEGA Gene Model | MGI Sequence Detail 49275 C57BL/6J ±  kb
transcript OTTMUST00000039864 VEGA | MGI Sequence Detail 4544 Not Applicable 
polypeptide OTTMUSP00000017783 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(18) UniProt(10)
Polymorphisms RFLP(2) : SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003912 RAC-beta serine/threonine-protein kinase
References (Earliest) J:32638 Staal SP, Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A. 1987 Jul;84(14):5034-7
(Latest) J:212069 Hung CM, et al., Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease. Cell Rep. 2014 Jul 10;8(1):256-71
All references(157)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-28173, MGI:1923730, MGI:2142261

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory