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Akt2 Gene Detail
Summary
  • Symbol
    Akt2
  • Name
    thymoma viral proto-oncogene 2
  • Synonyms
    2410016A19Rik, PKB, PKBbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:104874
    NCBI Gene: 11652
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27290977-27340251 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.94 cM, cytoband B1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1696 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104874
 protein coding gene Chr7:27290977-27340251 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031918
 protein coding gene Chr7:26265698-26323644 (+)
A/J MGP_AJ_G0031897
 protein coding gene Chr7:25620228-25674318 (+)
AKR/J MGP_AKRJ_G0031827
 protein coding gene Chr7:26306235-26357872 (+)
BALB/cJ MGP_BALBcJ_G0031902
 protein coding gene Chr7:25835394-25888263 (+)
C3H/HeJ MGP_C3HHeJ_G0031624
 protein coding gene Chr7:26683265-26738424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032367
 protein coding gene Chr7:27142308-27206464 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029419
 protein coding gene Chr7:26843905-26893947 (+)
CAST/EiJ MGP_CASTEiJ_G0030959
 protein coding gene Chr7:19991500-20066354 (+)
CBA/J MGP_CBAJ_G0031589
 protein coding gene Chr7:28331727-28396936 (+)
DBA/2J MGP_DBA2J_G0031741
 protein coding gene Chr7:25414895-25465927 (+)
FVB/NJ MGP_FVBNJ_G0031697
 protein coding gene Chr7:25516759-25570555 (+)
LP/J MGP_LPJ_G0031821
 protein coding gene Chr7:26589528-26661309 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031732
 protein coding gene Chr7:27899521-27953825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032398
 protein coding gene Chr7:25846556-25896132 (+)
PWK/PhJ MGP_PWKPhJ_G0030683
 protein coding gene Chr7:20465639-20514312 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030517
 protein coding gene Chr7:16827991-16878909 (+)
WSB/EiJ MGP_WSBEiJ_G0031067
 protein coding gene Chr7:26133013-26182255 (+)



Homology
more
  • Human Ortholog
    AKT2, AKT serine/threonine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKT2, AKT serine/threonine kinase 2
  • Synonyms
    HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
  • Links
    NCBI Gene ID: 208
    UniProt: P31751

  • Chr Location
    19q13.2; chr19:40230317-40285536 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Akt2 mouse models; 8 with human AKT2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 5 alleles in 7 genetic backgrounds
    46 phenotypes from multigenic genotypes
    179 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit insulin resistance and elevated plasma triglycerides. In males, the insulin resistance may progress to overt diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    119
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    94
  • cDNA Data
    18
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11652 NCBI Gene Model | MGI Sequence Detail 49275 C57BL/6J ±  kb
    transcript NM_001331108 RefSeq | MGI Sequence Detail 4660 ZRU/MplStud  
    polypeptide Q60823 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 19
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-28173, MGI:1923730, MGI:2142261
    References
    more
    • Summaries
      All 317
      Developmental Gene Expression 38
      Diseases 2
      Gene Ontology 27
      Phenotypes 179
    • Earliest
      J:32638 Staal SP, Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A. 1987 Jul;84(14):5034-7
    • Latest
      J:366763 Wing A, et al., Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRalpha signaling. Cell Rep. 2025 Apr 22;44(4):115527
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory