Akt2
Gene Detail

Symbol Name ID

Akt2 thymoma viral proto-oncogene 2 MGI:104874

Synonyms

2410016A19Rik, PKB, PKBbeta

Feature Type

protein coding gene

Genetic Map

Chromosome 7

15.94 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr7:27591552-27640826 bp, + strand From VEGA annotation of GRCm38   49275 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt2

Human homologs

Human Homolog		AKT2, v-akt murine thymoma viral oncogene homolog 2
NCBI Gene ID		208
neXtProt AC		NX_P31751
Human Synonyms		HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Human Chr (Location)		19q13.1-q13.2; chr19:40230317-40285536 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human AKT2

Alleles and phenotypes

All alleles(55) : Targeted(7) Gene trapped(48)
 

Homozygotes for targeted null mutations exhibit insulin resistance and elevated plasma triglycerides. In males, the insulin resistance may progress to overt diabetes.

 
Human Diseases Modeled Using Mouse Akt2 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (71 annotations)

Process	activation of Ral GTPase activity, apoptotic process, ...
Component	cell cortex, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (29 records)

Data Summary: Results (97)    Tissues (56)    Images (21)
Theiler Stages: 2, 19, 23, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	67
Western blot	27
RT-PCR	2

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(18) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016504 (Evidence)
Ensembl Gene Model	ENSMUSG00000004056 (Evidence)
Entrez Gene	11652 (Evidence)
NIA Mouse Gene Index	U007859, U028304
EC	2.7.11.1
Consensus CDS Project	CCDS21027.1
International Mouse Knockout Project Status	Akt2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016504	VEGA Gene Model | MGI Sequence Detail	49275	C57BL/6J
transcript	OTTMUST00000039865	VEGA | MGI Sequence Detail	3122	Not Applicable
polypeptide	OTTMUSP00000017784	VEGA | MGI Sequence Detail	481	Not Applicable

All sequences(108) RefSeq(18) UniProt(10)

Polymorphisms

RFLP(2) : SNPs within 2kb(220 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003912	RAC-beta serine/threonine-protein kinase

References

(Earliest) J:32638 Staal SP, Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A. 1987 Jul;84(14):5034-7
(Latest) J:206064 Tsen F, et al., Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec;33(24):4947-59
All references(151)

Other accession IDs

MGD-MRK-28173, MGI:1923730, MGI:2142261