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Lbx1
Gene Detail
Symbol

Name
ID
Lbx1
ladybird homeobox homolog 1 (Drosophila)
MGI:104867
Synonyms
Lbx1h
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.61 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:45232684-45235812 bp, - strand
From VEGA annotation of GRCm38

  3129 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4784  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LBX1
Gene Tree: Lbx1

Human
homologs
LBX1, ladybird homeobox 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10660
neXtProt AC: NX_P52954

Human Synonyms: homeobox, HPX6, HPX-6, LBX1H

Human Chr (Location): 10q24; chr10:101226212-101230327 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Genomic Mutations involving Lbx1 (3)
Incidental mutations (data from APF )
 
Homozygous null mice display impaired limb muscle development resulting from progenitor cell migration defects. Defects in heart development and nervous system morphology are also reported.
 
Interactions
Lbx1 interacts with 136 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, heart looping, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (216)    Tissues (120)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 141
In situ reporter (knock in) 48
Northern blot 10
RT-PCR 8
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lbx1 ; ZFIN lbx1b    NEW 
Molecular
reagents
All nucleic(19) Genomic(8) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037523 (Evidence)
Ensembl Gene Model ENSMUSG00000025216 (Evidence)
Entrez Gene 16814 (Evidence)
UniGene 116815
DFCI TC1679445, TC1591532
DoTS DT.101358187, DT.91327480
NIA Mouse Gene Index U039089
Consensus CDS Project CCDS29859.1
International Mouse Phenotyping Consortium Status Lbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037523 VEGA Gene Model | MGI Sequence Detail 3129 C57BL/6J ±  kb
transcript OTTMUST00000096729 VEGA | MGI Sequence Detail 2484 Not Applicable 
polypeptide OTTMUSP00000054072 VEGA | MGI Sequence Detail 282 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000009693 transcription factor LBX1
References
(Earliest) J:29933 Jagla K, et al., Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995 Nov;53(3):345-56
(Latest) J:220898 Goetz C, et al., Distinct limb and trunk premotor circuits establish laterality in the spinal cord. Neuron. 2015 Jan 7;85(1):131-44
All references(120)
Other
accession IDs
MGD-MRK-28164

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory