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Lbx1 Gene Detail
Summary
  • Symbol
    Lbx1
  • Name
    ladybird homeobox 1
  • Synonyms
    Lbx1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:104867
    NCBI Gene: 16814
  • Gene Overview
    MyGene.info: LBX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:45232684-45235812 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3129 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.61 cM, cytoband D
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LBX1, ladybird homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LBX1, ladybird homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    homeobox, HPX6, HPX-6, LBX1H
  • Links
    NCBI Gene ID: 10660
    neXtProt AC: NX_P52954
    UniProt: P52954

  • Chr Location
    10q24.32; chr10:101226976-101228960 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4784
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LBX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired limb muscle development resulting from progenitor cell migration defects. Defects in heart development and nervous system morphology are also reported.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037523 VEGA Gene Model | MGI Sequence Detail 3129 C57BL/6J ±  kb
    transcript OTTMUST00000096729 VEGA | MGI Sequence Detail 2484 Not Applicable  
    polypeptide OTTMUSP00000054072 VEGA | MGI Sequence Detail 282 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      26 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 8
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28164
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 95
      Gene Ontology 8
      Phenotypes 37
    • Earliest
      J:29933 Jagla K, et al., Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995 Nov;53(3):345-56
    • Latest
      J:254172 Vallecillo-Garcia P, et al., Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat Commun. 2017 Oct 31;8(1):1218

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory