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Rorc Gene Detail
Summary
  • Symbol
    Rorc
  • Name
    RAR-related orphan receptor gamma
  • Synonyms
    RORgamma, Thor, thymus orphan receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:104856
    NCBI Gene: 19885
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:94372794-94398276 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25483 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.56 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RORC, RAR related orphan receptor C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RORC, RAR related orphan receptor C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD42, NR1F3, RORG, RZRG, RZR-GAMMA, TOR
  • Links
    NCBI Gene ID: 6097
    neXtProt AC: NX_P51449
    UniProt: P51449

  • Chr Location
    1q21.3; chr1:151806071-151832450 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rorc mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 8 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    177 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit lack of peripheral and mesenteric lymph nodes and Peyer's patches, reduced numbers of thymocytes, and increased apoptosis with loss of thymic expression of anti-apoptosic factor Bcl-xL.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022692 VEGA Gene Model | MGI Sequence Detail 25483 C57BL/6J ±  kb
    transcript OTTMUST00000054423 VEGA | MGI Sequence Detail 2136 Not Applicable  
    polypeptide OTTMUSP00000025973 VEGA | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      229 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003079 Nuclear receptor ROR
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 2
      cDNA 39
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28153
    References
    more
    • Summaries
      All 264
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 24
      Phenotypes 177
    • Earliest
      J:30013 Ortiz MA, et al., TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol. 1995 Dec;9(12):1679-91
    • Latest
      J:264503 Buchele V, et al., Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis. Front Immunol. 2018;9:1138

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory