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Rorc
Gene Detail
Symbol

Name
ID
Rorc
RAR-related orphan receptor gamma
MGI:104856
Synonyms
RORgamma, Thor, thymus orphan receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.56 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:94372794-94398276 bp, + strand
From VEGA annotation of GRCm38

  25483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Rorc

Human
homologs
Human Homolog RORC, RAR-related orphan receptor C
NCBI Gene ID 6097
neXtProt AC  NX_P51449
Human Synonyms  NR1F3, RORG, RZRG, RZR-GAMMA, TOR
Human Chr (Location)  1q21; chr1:151806071-151831872 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit lack of peripheral and mesenteric lymph nodes and Peyer's patches, reduced numbers of thymocytes, and increased apoptosis with loss of thymic expression of anti-apoptosic factor Bcl-xL.
 
Interactions
Rorc interacts with 202 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (101)    Tissues (68)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
RT-PCR 1
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(2) cDNA(38) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022692 (Evidence)
Ensembl Gene ModelENSMUSG00000028150 (Evidence)
Entrez Gene19885 (Evidence)
UniGene4372
DFCITC1582154
DoTSDT.528240, DT.40135915, DT.97394341, DT.101352193
NIA Mouse Gene IndexU056310
Consensus CDS ProjectCCDS17591.1
International Mouse Knockout Project StatusRorc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022692 VEGA Gene Model | MGI Sequence Detail 25483 C57BL/6J ±  kb
transcript OTTMUST00000054423 VEGA | MGI Sequence Detail 2136 Not Applicable 
polypeptide OTTMUSP00000025973 VEGA | MGI Sequence Detail 516 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(11) UniProt(5)
Polymorphisms
SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003079 Nuclear receptor ROR
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000001902 nuclear receptor ROR-gamma
References
(Earliest) J:30013 Ortiz MA, et al., TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol. 1995 Dec;9(12):1679-91
(Latest) J:214818 von Burg N, et al., Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12835-40
All references(180)
Other
accession IDs
MGD-MRK-28153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory