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Rorc Gene Detail
Summary
  • Symbol
    Rorc
  • Name
    RAR-related orphan receptor gamma
  • Synonyms
    RORgamma, Thor, thymus orphan receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:104856
    NCBI Gene: 19885
Location & Maps
more
  • Sequence Map
    Chr3:94372794-94398276 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25483 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.56 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RORC, RAR related orphan receptor C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RORC, RAR related orphan receptor C
    Orthology source: HomoloGene
  • Synonyms
    IMD42, NR1F3, RORG, RZRG, RZR-GAMMA, TOR
  • Links
    NCBI Gene ID: 6097
    neXtProt AC: NX_P51449

  • Chr Location
    1q21; chr1:151806071-151832238 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RORC associations

Human Disease Mouse Models
       Immunodeficiency 42; IMD42   OMIM: 616622
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Rorc
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit lack of peripheral and mesenteric lymph nodes and Peyer's patches, reduced numbers of thymocytes, and increased apoptosis with loss of thymic expression of anti-apoptosic factor Bcl-xL.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022692 VEGA Gene Model | MGI Sequence Detail 25483 C57BL/6J ±  kb
transcript OTTMUST00000054423 VEGA | MGI Sequence Detail 2136 Not Applicable  
polypeptide OTTMUSP00000025973 VEGA | MGI Sequence Detail 516 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    229 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003079 Nuclear receptor ROR
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 42
    Genomic 2
    cDNA 38
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28153
References
more
  • Summaries
    All 201
    Developmental Gene Expression 12
    Gene Ontology 17
    Phenotypes 149
  • Earliest
    J:30013 Ortiz MA, et al., TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol. 1995 Dec;9(12):1679-91
  • Latest
    J:230488 Wichner K, et al., Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat. FASEB J. 2016 Feb;30(2):761-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory