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Rorc
Gene Detail
Symbol

Name
ID
Rorc
RAR-related orphan receptor gamma
MGI:104856
Synonyms
RORgamma, Thor, thymus orphan receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.56 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:94372831-94397839 bp, + strand
From Ensembl annotation of GRCm38

  25009 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: RORC
Gene Tree: Rorc

Human
homologs
RORC, RAR-related orphan receptor C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6097
neXtProt AC: NX_P51449

Human Synonyms: NR1F3, RORG, RZRG, RZR-GAMMA, TOR

Human Chr (Location): 1q21; chr1:151806071-151832238 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit lack of peripheral and mesenteric lymph nodes and Peyer's patches, reduced numbers of thymocytes, and increased apoptosis with loss of thymic expression of anti-apoptosic factor Bcl-xL.
 
Interactions
Rorc interacts with 202 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process adipose tissue development, alpha-beta T cell differentiation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (101)    Tissues (68)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
RT-PCR 1
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100489391 ; ZFIN rorca, rorcb    NEW 
Molecular
reagents
All nucleic(42) Genomic(2) cDNA(38) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000028150 (Evidence)
Entrez Gene 19885 (Evidence)
UniGene 4372
DFCI TC1582154
DoTS DT.97394341, DT.528240, DT.40135915, DT.101352193
NIA Mouse Gene Index U056310
Consensus CDS Project CCDS17591.1
International Mouse Phenotyping Consortium Status Rorc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028150 Ensembl Gene Model | MGI Sequence Detail 25009 C57BL/6J ±  kb
transcript ENSMUST00000029795 Ensembl | MGI Sequence Detail 2098 Not Applicable 
polypeptide ENSMUSP00000029795 Ensembl | MGI Sequence Detail 516 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(11) UniProt(3)
Polymorphisms
SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003079 Nuclear receptor ROR
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000001902 nuclear receptor ROR-gamma
References
(Earliest) J:30013 Ortiz MA, et al., TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol. 1995 Dec;9(12):1679-91
(Latest) J:219495 Rutz S, et al., Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015 Feb 19;518(7539):417-21
All references(184)
Other
accession IDs
MGD-MRK-28153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory