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Hes1
Gene Detail
Symbol

Name
ID
Hes1
hairy and enhancer of split 1 (Drosophila)
MGI:104853
Synonyms
bHLHb39, Hry
Feature Type
protein coding gene
Genetic Map
Chromosome 16
21.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:30064384-30067796 bp, + strand
From VEGA annotation of GRCm38

  3413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HES1
Gene Tree: Hes1

Human
homologs
HES1, hes family bHLH transcription factor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3280
neXtProt AC: NX_Q14469

Human Synonyms: bHLHb39, HES-1, HHL, HRY

Human Chr (Location): 3q28-q29; chr3:194136142-194138612 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants show anomalous timing in neurogenesis. Homozygotes for a null allele exhibit premature neurogenesis, severe neural tube defects, supernumerary hair cells in the inner ear, increased numbers of pulmonary neuroendocrine cells, and pancreatic hypoplasia. Death occurs in utero or neonatally.
 
Interactions
Hes1 interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (140 annotations)
Process adenohypophysis development, aorta morphogenesis, ...
Component chromatin, cytoplasm, ...
Function chaperone binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (316 records)
Data Summary: Results (552)    Tissues (220)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 481
Northern blot 13
RT-PCR 55
cDNA source data(38)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA HES4 ; Xenbase hes1 ; ZFIN her6    NEW 
Molecular
reagents
All nucleic(64) Genomic(2) cDNA(47) Primer pair(6) Other(9)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035113 (Evidence)
Ensembl Gene Model ENSMUSG00000022528 (Evidence)
Entrez Gene 15205 (Evidence)
UniGene 390859
DFCI TC1580852
DoTS DT.482267
NIA Mouse Gene Index U109237
Consensus CDS Project CCDS28098.1
International Mouse Phenotyping Consortium Status Hes1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035113 VEGA Gene Model | MGI Sequence Detail 3413 C57BL/6J ±  kb
transcript OTTMUST00000089350 VEGA | MGI Sequence Detail 1468 Not Applicable 
polypeptide OTTMUSP00000048828 VEGA | MGI Sequence Detail 282 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008515 transcription factor HES-1
References
(Earliest) J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
(Latest) J:220324 De Vas MG, et al., Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82
All references(403)
Other
accession IDs
MGD-MRK-10940, MGD-MRK-28150

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory