Hes1
Gene Detail

Symbol Name ID

Hes1 hairy and enhancer of split 1 (Drosophila) MGI:104853

Synonyms

bHLHb39, Hry

Feature Type

protein coding gene

Genetic Map

Chromosome 16

21.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr16:30064384-30067796 bp, + strand From VEGA annotation of GRCm38   3413 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Hes1

Human homologs

Human Homolog		HES1, hairy and enhancer of split 1, (Drosophila)
NCBI Gene ID		3280
neXtProt AC		NX_Q14469
Human Synonyms		bHLHb39, HES-1, HHL, HRY
Human Chr (Location)		3q28-q29; chr3:193853931-193856401 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Mutants show anomalous timing in neurogenesis. Homozygotes for a null allele exhibit premature neurogenesis, severe neural tube defects, supernumerary hair cells in the inner ear, increased numbers of pulmonary neuroendocrine cells, and pancreatic hypoplasia. Death occurs in utero or neonatally.

 

Gene Ontology (GO) classifications

All GO classifications: (114 annotations)

Process	adenohypophysis development, aorta morphogenesis, ...
Component	cytoplasm, intracellular, ...
Function	DNA binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (268 records)
Data Summary: Results (537)    Tissues (200)    Images (74)
Theiler Stages: 2, 3, 11, 12, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	472
Northern blot	13
RT-PCR	51

cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(2) cDNA(46) Primer pair(5) Other(8)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035113 (Evidence)
Ensembl Gene Model	ENSMUSG00000022528 (Evidence)
Entrez Gene	15205 (Evidence)
UniGene	390859
DFCI	TC1580852
DoTS	DT.482267
NIA Mouse Gene Index	U109237
Consensus CDS Project	CCDS28098.1
International Mouse Knockout Project Status	Hes1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035113	VEGA Gene Model | MGI Sequence Detail	3413	C57BL/6J
transcript	OTTMUST00000089350	VEGA | MGI Sequence Detail	1468	Not Applicable
polypeptide	OTTMUSP00000048828	VEGA | MGI Sequence Detail	282	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR003650	Orange
InterPro	IPR018352	Orange subgroup
Protein Ontology	PR:000008515	transcription factor HES-1

References

(Earliest) J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
(Latest) J:194596 Guiu J, et al., Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med. 2013 Jan 14;210(1):71-84
All references(348)

Other accession IDs

MGD-MRK-10940, MGD-MRK-28150