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Hes1
Gene Detail
 Symbol
Name
ID
Hes1
hairy and enhancer of split 1 (Drosophila)
MGI:104853
Synonyms bHLHb39, Hry
Feature Type protein coding gene
Genetic Map
Chromosome 16
21.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:30064384-30067796 bp, + strand
From VEGA annotation of GRCm38

  3413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

Gene Tree: Hes1

Human
homologs
Human Homolog HES1, hes family bHLH transcription factor 1
NCBI Gene ID 3280
neXtProt AC  NX_Q14469
Human Synonyms  bHLHb39, HES-1, HHL, HRY
Human Chr (Location)  3q28-q29; chr3:194136142-194138612 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants show anomalous timing in neurogenesis. Homozygotes for a null allele exhibit premature neurogenesis, severe neural tube defects, supernumerary hair cells in the inner ear, increased numbers of pulmonary neuroendocrine cells, and pancreatic hypoplasia. Death occurs in utero or neonatally.
 
Interactions
Hes1 interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (117 annotations)
Process adenohypophysis development, aorta morphogenesis, ...
Component cytoplasm, intracellular, ...
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (295 records)
Data Summary: Results (549)    Tissues (217)    Images (79)
Theiler Stages: 2, 3, 11, 12, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 478
Northern blot 13
RT-PCR 55
cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(2) cDNA(47) Primer pair(6) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035113 (Evidence)
Ensembl Gene ModelENSMUSG00000022528 (Evidence)
Entrez Gene15205 (Evidence)
UniGene390859
DFCITC1580852
DoTSDT.482267
NIA Mouse Gene IndexU109237
Consensus CDS ProjectCCDS28098.1
International Mouse Knockout Project StatusHes1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035113 VEGA Gene Model | MGI Sequence Detail 3413 C57BL/6J ±  kb
transcript OTTMUST00000089350 VEGA | MGI Sequence Detail 1468 Not Applicable 
polypeptide OTTMUSP00000048828 VEGA | MGI Sequence Detail 282 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
InterPro IPR018352 Orange subgroup
Protein Ontology PR:000008515 transcription factor HES-1
References (Earliest) J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
(Latest) J:210855 Moriyama M, et al., BNIP3 plays crucial roles in the differentiation and maintenance of epidermal keratinocytes. J Invest Dermatol. 2014 Jun;134(6):1627-35
All references(382)
Other
accession IDs
MGD-MRK-10940, MGD-MRK-28150

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory