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Hes1 Gene Detail
Summary
  • Symbol
    Hes1
  • Name
    hairy and enhancer of split 1 (Drosophila)
  • Synonyms
    bHLHb39, Hry
  • Feature Type
    protein coding gene
  • IDs
    MGI:104853
    NCBI Gene: 15205
  • Gene Overview
    MyGene.info: HES1
Location & Maps
more
  • Sequence Map
    Chr16:30064384-30067796 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3413 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HES1, hes family bHLH transcription factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HES1, hes family bHLH transcription factor 1
    Orthology source: HomoloGene
  • Synonyms
    bHLHb39, HES-1, HHL, HRY
  • Links
    NCBI Gene ID: 3280
    neXtProt AC: NX_Q14469

  • Chr Location
    3q28-q29; chr3:194136142-194138612 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 5 alleles in 8 genetic backgrounds
    50 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    8
  • Incidental Mutations
Mutants show anomalous timing in neurogenesis. Homozygotes for a null allele exhibit premature neurogenesis, severe neural tube defects, supernumerary hair cells in the inner ear, increased numbers of pulmonary neuroendocrine cells, and pancreatic hypoplasia. Death occurs in utero or neonatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035113 VEGA Gene Model | MGI Sequence Detail 3413 C57BL/6J ±  kb
transcript OTTMUST00000089350 VEGA | MGI Sequence Detail 1468 Not Applicable  
polypeptide OTTMUSP00000048828 VEGA | MGI Sequence Detail 282 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008515 transcription factor HES-1
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
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  • All nucleic 67
    Genomic 2
    cDNA 47
    Primer pair 8
    Other 10

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10940, MGD-MRK-28150
References
more
  • Summaries
    All 421
    Developmental Gene Expression 332
    Gene Ontology 48
    Phenotypes 87
  • Earliest
    J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
  • Latest
    J:227685 Shimojo H, et al., Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis. Genes Dev. 2016 Jan 1;30(1):102-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory