About   Help   FAQ
Adora3
Gene Detail
 Symbol
Name
ID
Adora3
adenosine A3 receptor
MGI:104847
Synonyms 1700001D09Rik, 4930578J19Rik, A3AR, A3R, AA3R, ARA3, Gpcr 2
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.45 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:105870858-105924042 bp, + strand
From NCBI annotation of GRCm38

  53185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:550  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 3 western clawed frog; 1 zebrafish

Protein SuperFamily: adenosine receptor

Human
homologs
Human Homolog ADORA3, adenosine A3 receptor
NCBI Gene ID 140
neXtProt AC  NX_P33765, NX_Q6P2N6
Human Synonyms  A3AR, AD026, bA552M11.5
Human Chr (Location)  1p13.2; chr1:111483348-111563977 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene are phenotypically indistinguishable from wild-type mice.
 
Interactions
Adora3 interacts with 156 markers (Mir7-1, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process adenosine receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled adenosine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (15)   
Theiler Stages: 13, 20, 23, 28
Assay TypeResults
RNA in situ 15
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000074344 (Evidence), ENSMUSG00000000562 (Evidence)
Entrez Gene11542 (Evidence)
UniGene235024
DFCITC1586345, TC1586677, TC1595590, TC1644730, TC1688137
DoTSDT.55226504, DT.60101389, DT.87045059, DT.91349522, DT.99848288
NIA Mouse Gene IndexU003698
Consensus CDS ProjectCCDS17712.1, CCDS38582.1, CCDS51036.1
International Mouse Knockout Project StatusAdora3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11542 NCBI Gene Model | MGI Sequence Detail 53185 C57BL/6J ±  kb
transcript NM_009631 RefSeq | MGI Sequence Detail 2372 C57BL/6 
polypeptide Q61618 UniProt | EBI | MGI Sequence Detail 319 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(8) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(391 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000466 Adenosine A3 receptor
InterPro IPR001634 Adenosine receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001578 adenosine receptor A3
Graphical View of Protein Domain Structure
References (Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:204608 Zhou X, et al., A1 adenosine receptor negatively modulates coronary reactive hyperemia via counteracting A2A-mediated H2O2 production and KATP opening in isolated mouse hearts. Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1668-79
All references(79)
Other
accession IDs
MGD-MRK-16343, MGD-MRK-28143, MGI:1916546, MGI:1923096, MGI:99563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory