Adora3
Gene Detail

Symbol Name ID

Adora3 adenosine A3 receptor MGI:104847

Synonyms

1700001D09Rik, 4930578J19Rik, A3AR, A3R, AA3R, ARA3, Gpcr 2

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.45 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:105870858-105924042 bp, + strand From NCBI annotation of GRCm38   53185 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenosine receptor

Human homologs

Human Homolog		ADORA3, adenosine A3 receptor
NCBI Gene ID		140
neXtProt AC		NX_P33765, NX_Q6P2N6
Human Synonyms		A3AR, AD026, bA552M11.5
Human Chr (Location)		1p13.2; chr1:112025970-112106597 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for targeted mutations that inactivate the gene are phenotypically indistinguishable from wild-type mice.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	adenosine receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled adenosine receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000074344 (Evidence), ENSMUSG00000000562 (Evidence)
Entrez Gene	11542 (Evidence)
UniGene	235024
DFCI	TC1586345, TC1586677, TC1595590, TC1644730, TC1688137
DoTS	DT.55226504, DT.60101389, DT.87045059, DT.91349522, DT.99848288
NIA Mouse Gene Index	U003698
Consensus CDS Project	CCDS17712.1, CCDS38582.1, CCDS51036.1
International Mouse Knockout Project Status	Adora3

Sequences

Length	Strain/Species
genomic	11542	NCBI Gene Model | MGI Sequence Detail	53185	C57BL/6J
transcript	NM_009631	RefSeq | MGI Sequence Detail	1797	NOD
polypeptide	Q61618	UniProt | EBI | MGI Sequence Detail	319	Not Applicable

All sequences(39) RefSeq(6) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(327 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000466	Adenosine A3 receptor
InterPro	IPR001634	Adenosine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001578	adenosine receptor A3

Graphical View of Protein Domain Structure

References

(Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:190598 Butler M, et al., Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo. Eur J Immunol. 2012 Dec;42(12):3358-68
All references(76)

Other accession IDs

MGD-MRK-16343, MGD-MRK-28143, MGI:1916546, MGI:1923096, MGI:99563