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Ier2 Gene Detail
Summary
  • Symbol
    Ier2
  • Name
    immediate early response 2
  • Synonyms
    ch1, pip92
  • Feature Type
    protein coding gene
  • IDs
    MGI:104815
    NCBI Gene: 15936
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84661331-84662852 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104815
protein coding gene Chr8:84661331-84662852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033864
protein coding gene Chr8:85568762-85570281 (-)
A/J MGP_AJ_G0033847
protein coding gene Chr8:82202642-82204161 (-)
AKR/J MGP_AKRJ_G0033773
protein coding gene Chr8:84635320-84636839 (-)
BALB/cJ MGP_BALBcJ_G0033840
protein coding gene Chr8:82323533-82325052 (-)
C3H/HeJ MGP_C3HHeJ_G0033550
protein coding gene Chr8:85252887-85254406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034360
protein coding gene Chr8:88855110-88856631 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031302
protein coding gene Chr8:75996762-75998273 (-)
CAST/EiJ MGP_CASTEiJ_G0032880
protein coding gene Chr8:84674884-84676406 (-)
CBA/J MGP_CBAJ_G0033526
protein coding gene Chr8:91904364-91905883 (-)
DBA/2J MGP_DBA2J_G0033680
protein coding gene Chr8:81841910-81843429 (-)
FVB/NJ MGP_FVBNJ_G0033627
protein coding gene Chr8:80779263-80780782 (-)
LP/J MGP_LPJ_G0033771
protein coding gene Chr8:85682950-85684469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033669
protein coding gene Chr8:94445214-94446732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034377
protein coding gene Chr8:84623956-84625477 (-)
PWK/PhJ MGP_PWKPhJ_G0032584
protein coding gene Chr8:81076807-81078328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032420
protein coding gene Chr8:83436206-83437714 (-)
WSB/EiJ MGP_WSBEiJ_G0032993
protein coding gene Chr8:85047970-85049489 (-)



Homology
more
  • Human Ortholog
    IER2, immediate early response 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IER2, immediate early response 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETR101
  • Links
    NCBI Gene ID: 9592
    neXtProt AC: NX_Q9BTL4
    UniProt: Q9BTL4

  • Chr Location
    19p13.13; chr19:13150468-13154908 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Ier2
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15936 NCBI Gene Model | MGI Sequence Detail 1522 C57BL/6J ±  kb
transcript NM_010499 RefSeq | MGI Sequence Detail 1541 C57BL/6  
polypeptide P17950 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 160
    Genomic 1
    cDNA 157
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28109, MGI:2142503
References
more
  • Summaries
    All 60
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 29
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory