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Siae
Gene Detail
Symbol

Name
ID
Siae
sialic acid acetylesterase
MGI:104803
Synonyms
clone 165, LSE, Ysg2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
20.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:37613847-37648318 bp, + strand
From VEGA annotation of GRCm38

  34472 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SIAE
Gene Tree: Siae

Human
homologs
SIAE, sialic acid acetylesterase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 54414
neXtProt AC: NX_Q9HAT2

Human Synonyms: AIS6, CSEC, CSE-C, LSE, YSG2

Human Chr (Location): 11q24; chr11:124635789-124676303 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SIAE

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have spleen hypoplasia, decreased T and B cell numbers, decreased threshold for B cell activation, and increased circulating levels of most immunoglobulin types including auto-antibodies.
 
Phenotype Images(1)
Interactions
Siae interacts with 231 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process carbohydrate metabolic process, regulation of immune system process
Component cytoplasm, extracellular exosome, ...
Function carboxylic ester hydrolase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (124)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
Northern blot 26
RT-PCR 2
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493404 ; ZFIN siae    NEW 
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000027448 (Evidence)
Ensembl Gene Model ENSMUSG00000001942 (Evidence)
Entrez Gene 22619 (Evidence)
DFCI TC1708100, TC1576185
NIA Mouse Gene Index U010262
EC 3.1.1.53
Consensus CDS Project CCDS22983.1
International Mouse Phenotyping Consortium Status Siae
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027448 VEGA Gene Model | MGI Sequence Detail 34472 C57BL/6J ±  kb
transcript OTTMUST00000067917 VEGA | MGI Sequence Detail 3433 Not Applicable 
polypeptide OTTMUSP00000034250 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005181 Domain of unknown function DUF303, acetylesterase putative
Protein Ontology PR:000014859 sialate O-acetylesterase
References
(Earliest) J:37624 Butor C, et al., Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver. J Biol Chem. 1993 May 15;268(14):10207-13
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGD-MRK-28096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory