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Siae
Gene Detail
 Symbol
Name
ID
Siae
sialic acid acetylesterase
MGI:104803
Synonyms clone 165, LSE, Ysg2
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:37613847-37648318 bp, + strand
From VEGA annotation of GRCm38

  34472 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Siae

Human
homologs
Human Homolog SIAE, sialic acid acetylesterase
NCBI Gene ID 54414
neXtProt AC  NX_Q9HAT2
Human Synonyms  AIS6, CSEC, CSE-C, LSE, YSG2
Human Chr (Location)  11q24; chr11:124635789-124676303 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SIAE
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have spleen hypoplasia, decreased T and B cell numbers, decreased threshold for B cell activation, and increased circulating levels of most immunoglobulin types including auto-antibodies.
 
Phenotype Images(1)
Interactions
Siae interacts with 231 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process carbohydrate metabolic process, regulation of immune system process
Component cytoplasm, extracellular space, ...
Function carboxylic ester hydrolase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (124)    Images (16)
Theiler Stages: 13, 14, 19, 22, 23, 28
Assay TypeResults
RNA in situ 113
Northern blot 26
RT-PCR 2
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000027448 (Evidence)
Ensembl Gene ModelENSMUSG00000001942 (Evidence)
Entrez Gene22619 (Evidence)
DFCITC1576185, TC1708100
NIA Mouse Gene IndexU010262
EC3.1.1.53
Consensus CDS ProjectCCDS22983.1
International Mouse Knockout Project StatusSiae
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027448 VEGA Gene Model | MGI Sequence Detail 34472 C57BL/6J ±  kb
transcript OTTMUST00000067917 VEGA | MGI Sequence Detail 3433 Not Applicable 
polypeptide OTTMUSP00000034250 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005181 Domain of unknown function DUF303, acetylesterase putative
Protein Ontology PR:000014859 sialate O-acetylesterase
References (Earliest) J:37624 Butor C, et al., Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver. J Biol Chem. 1993 May 15;268(14):10207-13
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-28096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory