Siae
Gene Detail

Symbol Name ID

Siae sialic acid acetylesterase MGI:104803

Synonyms

clone 165, LSE, Ysg2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

20.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:37613847-37648318 bp, + strand From VEGA annotation of GRCm38   34472 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Siae

Human homologs

Human Homolog		SIAE, sialic acid acetylesterase
NCBI Gene ID		54414
neXtProt AC		NX_Q9HAT2
Human Synonyms		AIS6, CSEC, CSE-C, LSE, YSG2
Human Chr (Location)		11q24; chr11:124505685-124546199 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SIAE

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a null allele have spleen hypoplasia, decreased T and B cell numbers, decreased threshold for B cell activation, and increased circulating levels of most immunoglobulin types including auto-antibodies.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component	cytoplasm, lysosome
Function	carboxylesterase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (124)    Images (16)
Theiler Stages: 13, 14, 19, 22, 23, 28

Assay Type	Results
RNA in situ	113
Northern blot	26
RT-PCR	2

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000027448 (Evidence)
Ensembl Gene Model	ENSMUSG00000001942 (Evidence)
Entrez Gene	22619 (Evidence)
DFCI	TC1576185, TC1708100
NIA Mouse Gene Index	U010262
EC	3.1.1.53
Consensus CDS Project	CCDS22983.1
International Mouse Knockout Project Status	Siae

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027448	VEGA Gene Model | MGI Sequence Detail	34472	C57BL/6J
transcript	OTTMUST00000067917	VEGA | MGI Sequence Detail	3433	Not Applicable
polypeptide	OTTMUSP00000034250	VEGA | MGI Sequence Detail	541	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005181	Domain of unknown function DUF303, acetylesterase putative
Protein Ontology	PR:000014859	sialate O-acetylesterase

References

(Earliest) J:37624 Butor C, et al., Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver. J Biol Chem. 1993 May 15;268(14):10207-13
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGD-MRK-28096