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Prkdc
Gene Detail
 Symbol
Name
ID
Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779
Synonyms DNAPDcs, DNA-PK, DNA-PKcs, DOXNPH, dxnph, slip, XRCC7
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.09 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr16:15637866-15842235 bp, + strand
From VEGA annotation of GRCm38

  204370 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prkdc

Human
homologs
Human Homolog PRKDC, protein kinase, DNA-activated, catalytic polypeptide
NCBI Gene ID 5591
neXtProt AC  NX_P78527
Human Synonyms  DNAPK, DNA-PKcs, DNPK1, HYRC, HYRC1, p350, XRCC7
Human Chr (Location)  8q11; chr8:47773108-47960183 (-)  GRCh38
Alleles
and
phenotypes
All alleles(29) : Targeted(4) Gene trapped(17) Transgenic(1) Spontaneous(2) Chemically induced(4) QTL(1)
 
Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer.
 
Human Diseases Modeled Using Mouse Prkdc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process B cell lineage commitment, brain development, ...
Component DNA-dependent protein kinase-DNA ligase 4 complex, intracellular, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (17)    Tissues (9)    Images (19)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 17
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(3) cDNA(25)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043440 (Evidence)
Ensembl Gene ModelENSMUSG00000022672 (Evidence)
Entrez Gene19090 (Evidence)
UniGene71
DFCITC1584747, TC1639046
DoTSDT.488196, DT.91414116
NIA Mouse Gene IndexU016848
EC2.7.11.1
Consensus CDS ProjectCCDS27978.1
International Mouse Knockout Project StatusPrkdc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043440 VEGA Gene Model | MGI Sequence Detail 204370 C57BL/6J ±  kb
transcript OTTMUST00000113952 VEGA | MGI Sequence Detail 12647 Not Applicable 
polypeptide OTTMUSP00000063630 VEGA | MGI Sequence Detail 4128 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(14) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(579 from dbSNP Build 137)    SNPs within 2kb including multiple locations(583)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR012582 NUC194
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR014009 PIK-related kinase
InterPro IPR003151 PIK-related kinase, FAT
InterPro IPR003152 PIK-related kinase, FATC
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000013239 DNA-dependent protein kinase catalytic subunit
References (Earliest) J:5237 Graff RJ, Polymorphism of histocompatibility genes in the mouse. Transplant Proc. 1970 Mar;2(1):15-23
(Latest) J:207087 Bello-Irizarry SN, et al., MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection. J Immunol. 2014 Jan 1;192(1):282-92
All references(783)
Other
accession IDs
MGD-MRK-14312, MGD-MRK-28071, MGI:2146417, MGI:2146554, MGI:3574416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory