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Cdk2 Gene Detail
Summary
  • Symbol
    Cdk2
  • Name
    cyclin-dependent kinase 2
  • Synonyms
    A630093N05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:104772
    NCBI Gene: 12566
  • Gene Overview
    MyGene.info: CDK2
Location & Maps
more
  • Sequence Map
    Chr10:128697939-128705051 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7113 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CDK2, cyclin-dependent kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK2, cyclin-dependent kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDKN2, p33(CDK2)
  • Links
    NCBI Gene ID: 1017
    neXtProt AC: NX_P24941

  • Chr Location
    12q13; chr12:55966769-55972789 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 4 genetic backgrounds
    56 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    14
  • Targeted
    9
Reproductive system abnormalities are observed in mice homozygous for disruptions in this gene. Gametogenesis fails in both males and females, leading to atrophy of the testes and ovaries. Both sexes are sterile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025358 Ensembl Gene Model | MGI Sequence Detail 7113 C57BL/6J ±  kb
transcript ENSMUST00000026416 Ensembl | MGI Sequence Detail 2432 Not Applicable  
polypeptide ENSMUSP00000026416 Ensembl | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 97
    cDNA 95
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-28064, MGI:2443873
References
more
  • Summaries
    All 175
    Developmental Gene Expression 63
    Gene Ontology 20
    Phenotypes 38
  • Earliest
    J:19954 Tsai LH, et al., Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 1991 Sep 12;353(6340):174-7
  • Latest
    J:228026 Capecchi MR, et al., ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 2015;6:8763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory