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Cdk2
Gene Detail
 Symbol
Name
ID
Cdk2
cyclin-dependent kinase 2
MGI:104772
Synonyms A630093N05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
77.13 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:128697939-128705051 bp, - strand
From NCBI annotation of GRCm38

  7113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk2

Human
homologs
Human Homolog CDK2, cyclin-dependent kinase 2
NCBI Gene ID 1017
neXtProt AC  NX_P24941
Human Synonyms  CDKN2, p33(CDK2)
Human Chr (Location)  12q13; chr12:55966772-55972784 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(14) Targeted(7)
 
Reproductive system abnormalities are observed in mice homozygous for disruptions in this gene. Gametogenesis fails in both males and females, leading to atrophy of the testes and ovaries. Both sexes are sterile.
 
Interactions
Cdk2 interacts with 189 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process cell cycle, cell division, ...
Component Cajal body, chromosome, telomeric region, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (152)    Tissues (125)    Images (15)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 106
Western blot 40
cDNA source data(95)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(95) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025358 (Evidence)
Entrez Gene12566 (Evidence)
UniGene111326
DFCITC1572708, TC1588521, TC1595911, TC1609221, TC1615928, TC1768250
DoTSDT.101388442, DT.490287, DT.55237224, DT.91566446, DT.97346272, DT.97382962
NIA Mouse Gene IndexU032372
EC2.7.11.22
Consensus CDS ProjectCCDS24288.1, CCDS24289.1
International Mouse Knockout Project StatusCdk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12566 NCBI Gene Model | MGI Sequence Detail 7113 C57BL/6J ±  kb
transcript NM_183417 RefSeq | MGI Sequence Detail 2432 C57BL/6 
polypeptide P97377 UniProt | EBI | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005253 cyclin-dependent kinase 2
Graphical View of Protein Domain Structure
References (Earliest) J:19954 Tsai LH, et al., Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 1991 Sep 12;353(6340):174-7
(Latest) J:206964 Wu X, et al., A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior. J Neurosci. 2014 Jan 22;34(4):1510-22
All references(166)
Other
accession IDs
MGD-MRK-28064, MGI:2443873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory