Cdk2
Gene Detail

Symbol Name ID

Cdk2 cyclin-dependent kinase 2 MGI:104772

Synonyms

A630093N05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 10

77.13 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:128697939-128705051 bp, - strand From NCBI annotation of GRCm38   7113 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk2

Human homologs

Human Homolog		CDK2, cyclin-dependent kinase 2
NCBI Gene ID		1017
neXtProt AC		NX_P24941
Human Synonyms		p33(CDK2)
Human Chr (Location)		12q13; chr12:56360556-56366568 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(7) Gene trapped(14)
 

Reproductive system abnormalities are observed in mice homozygous for disruptions in this gene. Gametogenesis fails in both males and females, leading to atrophy of the testes and ovaries. Both sexes are sterile.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	cell cycle, cell division, ...
Component	Cajal body, chromosome, telomeric region, ...
Function	ATP binding, cyclin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (48 records)
Data Summary: Results (152)    Tissues (125)    Images (15)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	106
Western blot	40

cDNA source data(95)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) cDNA(95) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025358 (Evidence)
Entrez Gene	12566 (Evidence)
UniGene	111326
DFCI	TC1572708, TC1588521, TC1595911, TC1609221, TC1615928, TC1768250
DoTS	DT.101388442, DT.490287, DT.55237224, DT.91566446, DT.97346272, DT.97382962
NIA Mouse Gene Index	U032372
EC	2.7.11.22
Consensus CDS Project	CCDS24288.1, CCDS24289.1
International Mouse Knockout Project Status	Cdk2

Sequences

Length	Strain/Species
genomic	12566	NCBI Gene Model | MGI Sequence Detail	7113	C57BL/6J
transcript	NM_183417	RefSeq | MGI Sequence Detail	2432	C57BL/6
polypeptide	P97377	UniProt | EBI | MGI Sequence Detail	346	Not Applicable

All sequences(59) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005253	cyclin-dependent kinase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:19954 Tsai LH, et al., Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 1991 Sep 12;353(6340):174-7
(Latest) J:194573 Lim S, et al., Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells. Stem Cells. 2012 Jul;30(7):1509-20
All references(155)

Other accession IDs

MGD-MRK-28064, MGI:2443873