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Cdk2
Gene Detail
Symbol

Name
ID
Cdk2
cyclin-dependent kinase 2
MGI:104772
Synonyms
A630093N05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.13 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:128697939-128705051 bp, - strand
From Ensembl annotation of GRCm38

  7113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK2
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk2

Human
homologs
CDK2, cyclin-dependent kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1017
neXtProt AC: NX_P24941

Human Synonyms: CDKN2, p33(CDK2)

Human Chr (Location): 12q13; chr12:55966769-55972789 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(14) Targeted(8)
 
Reproductive system abnormalities are observed in mice homozygous for disruptions in this gene. Gametogenesis fails in both males and females, leading to atrophy of the testes and ovaries. Both sexes are sterile.
 
Interactions
Cdk2 interacts with 188 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process cell cycle, cell division, ...
Component Cajal body, chromosome, telomeric region, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (158)    Tissues (128)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 106
Western blot 40
RT-PCR 4
cDNA source data(95)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk2 ; ZFIN cdk2    NEW 
Molecular
reagents
All nucleic(97) cDNA(95) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000025358 (Evidence)
Entrez Gene 12566 (Evidence)
UniGene 111326
DFCI TC1572708, TC1588521, TC1595911, TC1609221, TC1615928, TC1768250
DoTS DT.101388442, DT.490287, DT.55237224, DT.91566446, DT.97346272, DT.97382962
NIA Mouse Gene Index U032372
EC 2.7.11.22
Consensus CDS Project CCDS24288.1, CCDS24289.1
International Mouse Phenotyping Consortium Status Cdk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025358 Ensembl Gene Model | MGI Sequence Detail 7113 C57BL/6J ±  kb
transcript ENSMUST00000026416 Ensembl | MGI Sequence Detail 2432 Not Applicable 
polypeptide ENSMUSP00000026416 Ensembl | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005253 cyclin-dependent kinase 2
References
(Earliest) J:19954 Tsai LH, et al., Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 1991 Sep 12;353(6340):174-7
(Latest) J:218629 Gillam MP, et al., MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2. Oncogene. 2015 Feb 12;34(7):932-8
All references(178)
Other
accession IDs
MGD-MRK-28064, MGI:2443873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory