58 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk1tm1(Cdk2)Kald/Cdk1+ involves: 129 * C57BL/6	no abnormal phenotype detected	J:141249
Cdk1tm1(Cdk2)Kald/Cdk1+ Cdk2tm1Kald/Cdk2tm1Kald involves: 129S1/Sv * C57BL/6	abnormal female reproductive system morphology	J:141249
	abnormal male meiosis	J:141249
	abnormal male reproductive system morphology	J:141249
	abnormal spermatid morphology	J:141249
	abnormal spermatocyte morphology	J:141249
	abnormal spermatogenesis	J:141249
	absent oocytes	J:141249
	absent ovarian follicles	J:141249
	female infertility	J:141249
	increased male germ cell apoptosis	J:141249
	infertility	J:141249
	male infertility	J:141249
	small ovary	J:141249
	small seminiferous tubules	J:141249
	small testis	J:141249
Cdk1tm1(Cdk2)Kald/Cdk1tm1(Cdk2)Kald involves: 129 * C57BL/6	embryonic lethality before implantation, complete penetrance	J:141249
Cdk2tm1Kald/Cdk2tm1Kald Cdk4tm1Kiyo/Cdk4tm1Kiyo involves: 129S1/Sv * C57BL/6	abnormal cardiac output	J:108720
	abnormal cell cycle	J:108720
	abnormal erythrocyte morphology	J:108720
	abnormal eye morphology	J:108720
	abnormal fetal cardiomyocyte proliferation	J:108720
	abnormal heart valve morphology	J:108720
	abnormal hematopoietic stem cell morphology	J:108720
	abnormal liver morphology	J:108720
	decreased cell proliferation	J:108720
	decreased embryo size	J:108720
	edema	J:108720
	hemorrhage	J:108720
	increased heart atrium size	J:108720
	lethality throughout fetal growth and development, incomplete penetrance	J:108720
	myocardial fiber disarray	J:108720
	pallor	J:108720
	small heart	J:108720
	thin ventricular wall	J:108720
	ventricular septal defect	J:108720
Cdk2tm1Kald/Cdk2tm1Kald Cdk4tm1Kiyo/Cdk4tm1Kiyo Cdkn1btm1Ako/Cdkn1btm1Ako involves: 129S1/Sv * C57BL/6	decreased cell proliferation	J:108720
	lethality throughout fetal growth and development, complete penetrance	J:108720
Cdk2tm1Sgo/Cdk2+ Cdk4tm2.1Bbd/Cdk4+ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	abnormal embryo development	J:125217
Cdk2tm1Sgo/Cdk2tm1Sgo Cdk4tm1Bbd/Cdk4tm1Bbd Cdk6tm1Bbd/Cdk6tm1Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal common myeloid progenitor cell morphology	J:124678
	decreased cell proliferation	J:124678
	decreased embryo size	J:124678
	decreased myocardial fiber number	J:124678
	embryonic lethality during organogenesis, incomplete penetrance	J:124678
	lethality throughout fetal growth and development, complete penetrance	J:124678
	liver hypoplasia	J:124678
	thin ventricular wall	J:124678
Cdk2tm1Sgo/Cdk2tm1Sgo Cdk4tm2.1Bbd/Cdk4tm2.1Bbd involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	abnormal cell cycle	J:125217
	abnormal definitive hematopoiesis	J:125217
	abnormal fetal cardiomyocyte proliferation	J:125217
	abnormal liver physiology	J:125217
	congestive heart failure	J:125217
	decreased body weight	J:125217
	decreased erythrocyte cell number	J:125217
	decreased fibroblast proliferation	J:125217
	increased myocardial fiber size	J:125217
	liver hypoplasia	J:125217
	neonatal lethality, complete penetrance	J:125217
	thin ventricular wall	J:125217
Cdk2tm1Sgo/Cdk2tm1Sgo Cdk6tm1Bbd/Cdk6tm1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal gametogenesis	J:92529
	abnormal oogenesis	J:92529
	abnormal spermatogenesis	J:92529
	infertility	J:92529
Cdk2tm1Sgo/Cdk2tm1Sgo Krastm1Bbd/Kras+ Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780
Cdk2tm2Sgo/Cdk2tm2Sgo Cdk4tm2.1Bbd/Cdk4tm2.1Bbd Polr2atm1(cre/ERT2)Bbd/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	decreased body size	J:125217
	normal hematopoietic system phenotype	J:125217
	increased susceptibility to autoimmune diabetes	J:125217
	normal liver/biliary system phenotype	J:125217
Cdk2tm2Sgo/Cdk2tm2Sgo Krastm1Bbd/Krastm2Bbd Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780