Kcnj5
Gene Detail

Symbol Name ID

Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 MGI:104755

Synonyms

GIRK4, Kir3.4

Feature Type

protein coding gene

Genetic Map

Chromosome 9

17.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:32314783-32344237 bp, - strand From NCBI annotation of GRCm38   29455 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj5

Human homologs

Human Homolog		KCNJ5, potassium inwardly-rectifying channel, subfamily J, member 5
NCBI Gene ID		3762
neXtProt AC		NX_P48544
Human Synonyms		CIR, GIRK4, KATP1, KIR3.4, LQT13
Human Chr (Location)		11q24; chr11:128761313-128787964 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human KCNJ5

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for a targeted null mutation exhibit mild resting tachycardias and reduced muscarinic-gated atrial potassium channel responses to pharmacological stimulation.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	ion transport, potassium ion transport, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (87)    Tissues (53)    Images (24)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	23
Northern blot	12
RT-PCR	52

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(3) cDNA(11) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032034 (Evidence)
Entrez Gene	16521 (Evidence)
UniGene	69472
DFCI	TC1599062, TC1611903, TC1672069
DoTS	DT.87047096, DT.91333639
NIA Mouse Gene Index	U030652
Consensus CDS Project	CCDS22952.1
International Mouse Knockout Project Status	Kcnj5

Sequences

Length	Strain/Species
genomic	16521	NCBI Gene Model | MGI Sequence Detail	29455	C57BL/6J
transcript	NM_010605	RefSeq | MGI Sequence Detail	4496	C57BL/6
polypeptide	P48545	UniProt | EBI | MGI Sequence Detail	419	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003277	Potassium channel, inwardly rectifying, Kir3.4
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000002005	G protein-activated inward rectifier potassium channel 4

Graphical View of Protein Domain Structure

References

(Earliest) J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(50)

Other accession IDs

MGD-MRK-28046