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Kcnj5 Gene Detail
Summary
  • Symbol
    Kcnj5
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 5
  • Synonyms
    GIRK4, Kir3.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104755
    NCBI Gene: 16521
  • Gene Overview
    MyGene.info: KCNJ5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:32314707-32344350 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 17.65 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104755
protein coding gene Chr9:32314706-32344380 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034523
protein coding gene Chr9:30056399-30088480 (-)
A/J MGP_AJ_G0034501
protein coding gene Chr9:29286969-29317749 (-)
AKR/J MGP_AKRJ_G0034427
protein coding gene Chr9:29920875-29950201 (-)
BALB/cJ MGP_BALBcJ_G0034492
protein coding gene Chr9:29179698-29210692 (-)
C3H/HeJ MGP_C3HHeJ_G0034204
protein coding gene Chr9:30267426-30300184 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035013
protein coding gene Chr9:31077784-31111711 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031943
protein coding gene Chr9:28084206-28115278 (-)
CAST/EiJ MGP_CASTEiJ_G0033527
protein coding gene Chr9:30132532-30162457 (-)
CBA/J MGP_CBAJ_G0034178
protein coding gene Chr9:32112073-32148843 (-)
DBA/2J MGP_DBA2J_G0034335
protein coding gene Chr9:29295700-29326122 (-)
FVB/NJ MGP_FVBNJ_G0034278
protein coding gene Chr9:28700831-28732300 (-)
LP/J MGP_LPJ_G0034421
protein coding gene Chr9:30274194-30304065 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034322
protein coding gene Chr9:33734732-33769071 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035033
protein coding gene Chr9:29911719-29943891 (-)
PWK/PhJ MGP_PWKPhJ_G0033232
protein coding gene Chr9:29254252-29284893 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033067
protein coding gene Chr9:30021994-30051633 (-)
WSB/EiJ MGP_WSBEiJ_G0033642
protein coding gene Chr9:29661992-29694592 (-)



Homology
more
  • Human Ortholog
    KCNJ5, potassium voltage-gated channel subfamily J member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ5, potassium voltage-gated channel subfamily J member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIR, GIRK4, KATP1, KIR3.4, LQT13
  • Links
    NCBI Gene ID: 3762
    neXtProt AC: NX_P48544
    UniProt: P48544

  • Chr Location
    11q24.3; chr11:128891418-128921163 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human KCNJ5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit mild resting tachycardias and reduced muscarinic-gated atrial potassium channel responses to pharmacological stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032034 Ensembl Gene Model | MGI Sequence Detail 29644 C57BL/6J ±  kb
transcript ENSMUST00000214223 Ensembl | MGI Sequence Detail 3101 Not Applicable  
polypeptide ENSMUSP00000149000 Ensembl | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002005 G protein-activated inward rectifier potassium channel 4
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003277 Potassium channel, inwardly rectifying, Kir3.4
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 19
    Genomic 3
    cDNA 13
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28046
References
more
  • Summaries
    All 59
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
  • Latest
    J:261949 Kulkarni K, et al., The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart. PLoS One. 2018;13(4):e0193798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory