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Kcnj5
Gene Detail
Symbol

Name
ID
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
MGI:104755
Synonyms
GIRK4, Kir3.4
Feature Type
protein coding gene
Genetic Map
Chromosome 9
17.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:32314783-32344237 bp, - strand
From Ensembl annotation of GRCm38

  29455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNJ5
Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj5

Human
homologs
KCNJ5, potassium channel, inwardly rectifying subfamily J, member 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3762
neXtProt AC: NX_P48544

Human Synonyms: CIR, GIRK4, KATP1, KIR3.4, LQT13

Human Chr (Location): 11q24; chr11:128891418-128921163 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human KCNJ5

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit mild resting tachycardias and reduced muscarinic-gated atrial potassium channel responses to pharmacological stimulation.
 
Interactions
Kcnj5 interacts with 269 markers (Mir1a-2, Mir1b, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (87)    Tissues (55)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
Northern blot 12
RT-PCR 52
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnj5    NEW 
Molecular
reagents
All nucleic(17) Genomic(3) cDNA(11) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000032034 (Evidence)
Entrez Gene 16521 (Evidence)
UniGene 69472
DFCI TC1599062, TC1611903, TC1672069
DoTS DT.87047096, DT.91333639
NIA Mouse Gene Index U030652
Consensus CDS Project CCDS22952.1
International Mouse Phenotyping Consortium Status Kcnj5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032034 Ensembl Gene Model | MGI Sequence Detail 29455 C57BL/6J ±  kb
transcript ENSMUST00000034533 Ensembl | MGI Sequence Detail 4496 Not Applicable 
polypeptide ENSMUSP00000034533 Ensembl | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(392 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003277 Potassium channel, inwardly rectifying, Kir3.4
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002005 G protein-activated inward rectifier potassium channel 4
References
(Earliest) J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
(Latest) J:219541 Liang B, et al., G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization. Cardiovasc Res. 2014 Jan 1;101(1):175-84
All references(52)
Other
accession IDs
MGD-MRK-28046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory