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Kcnj5
Gene Detail
 Symbol
Name
ID
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
MGI:104755
Synonyms GIRK4, Kir3.4
Feature Type protein coding gene
Genetic Map
Chromosome 9
17.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:32314783-32344237 bp, - strand
From NCBI annotation of GRCm38

  29455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj5

Human
homologs
Human Homolog KCNJ5, potassium inwardly-rectifying channel, subfamily J, member 5
NCBI Gene ID 3762
neXtProt AC  NX_P48544
Human Synonyms  CIR, GIRK4, KATP1, KIR3.4, LQT13
Human Chr (Location)  11q24; chr11:128891418-128921165 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human KCNJ5
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit mild resting tachycardias and reduced muscarinic-gated atrial potassium channel responses to pharmacological stimulation.
 
Interactions
Kcnj5 interacts with 270 markers (Mir1a-2, Mir1b, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component external side of plasma membrane, integral component of membrane, ...
Function G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (87)    Tissues (55)    Images (24)
Theiler Stages: 10, 18, 23, 25, 27, 28
Assay TypeResults
RNA in situ 23
Northern blot 12
RT-PCR 52
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(3) cDNA(11) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032034 (Evidence)
Entrez Gene16521 (Evidence)
UniGene69472
DFCITC1599062, TC1611903, TC1672069
DoTSDT.87047096, DT.91333639
NIA Mouse Gene IndexU030652
Consensus CDS ProjectCCDS22952.1
International Mouse Knockout Project StatusKcnj5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16521 NCBI Gene Model | MGI Sequence Detail 29455 C57BL/6J ±  kb
transcript NM_010605 RefSeq | MGI Sequence Detail 4496 C57BL/6 
polypeptide P48545 UniProt | EBI | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(392 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003277 Potassium channel, inwardly rectifying, Kir3.4
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002005 G protein-activated inward rectifier potassium channel 4
Graphical View of Protein Domain Structure
References (Earliest) J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
(Latest) J:209181 Posokhova E, et al., Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. PLoS One. 2013;8(10):e76973
All references(51)
Other
accession IDs
MGD-MRK-28046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory