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Kcnj5 Gene Detail
Summary
  • Symbol
    Kcnj5
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 5
  • Synonyms
    GIRK4, Kir3.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104755
    NCBI Gene: 16521
  • Gene Overview
    MyGene.info: KCNJ5
Location & Maps
more
  • Sequence Map
    Chr9:32314783-32344237 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29455 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 17.65 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    KCNJ5, potassium voltage-gated channel subfamily J member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ5, potassium voltage-gated channel subfamily J member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIR, GIRK4, KATP1, KIR3.4, LQT13
  • Links
    NCBI Gene ID: 3762
    neXtProt AC: NX_P48544

  • Chr Location
    11q24; chr11:128891418-128921163 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human KCNJ5 associations

Human Disease Mouse Models
       Hyperaldosteronism, Familial, Type III; HALD3   OMIM: 613677
Long QT Syndrome 13; LQT13   OMIM: 613485
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit mild resting tachycardias and reduced muscarinic-gated atrial potassium channel responses to pharmacological stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032034 Ensembl Gene Model | MGI Sequence Detail 29455 C57BL/6J ±  kb
transcript ENSMUST00000034533 Ensembl | MGI Sequence Detail 4496 Not Applicable  
polypeptide ENSMUSP00000034533 Ensembl | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    390 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000002005 G protein-activated inward rectifier potassium channel 4
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003277 Potassium channel, inwardly rectifying, Kir3.4
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 17
    Genomic 3
    cDNA 11
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28046
References
more
  • Summaries
    All 50
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
  • Latest
    J:225207 Mesirca P, et al., Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nat Commun. 2014;5:4664

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory