Nfasc
Gene Detail

Symbol Name ID

Nfasc neurofascin MGI:104753

Synonyms

D430023G06Rik, mKIAA0756, NF155, NF186

Feature Type

protein coding gene

Genetic Map

Chromosome 1

57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:132564691-132741797 bp, - strand From Ensembl annotation of GRCm38   177107 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:24945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Nfasc

Human homologs

Human Homolog		NFASC, neurofascin
NCBI Gene ID		23114
neXtProt AC		NX_O94856
Human Synonyms		NF, NRCAML
Human Chr (Location)		1q32.1; chr1:204797782-204991950 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(6) Gene trapped(8)
 

Mice homozygous for a null allele die within 6 to 7 days of birth, exhibit reduced nerve conduction velocity and abnormal paranodal junction formation.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	axon guidance, cell adhesion, ...
Component	axon, axon initial segment, ...
Function	protein binding involved in heterotypic cell-cell adhesion, protein domain specific binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (59)    Tissues (9)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	59

cDNA source data(119)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(120) cDNA(119) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026442 (Evidence)
Entrez Gene	269116 (Evidence)
UniGene	326702
DFCI	TC1578072, TC1584139, TC1602525, TC1606218, TC1612209, TC1626707, TC1650085
DoTS	DT.101738051, DT.110918369, DT.40135206, DT.40142845, DT.55161513, DT.91403863, DT.99854297
NIA Mouse Gene Index	U021764, U152485
Consensus CDS Project	CCDS35707.1, CCDS48358.1, CCDS48359.1
International Mouse Knockout Project Status	Nfasc

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026442	Ensembl Gene Model | MGI Sequence Detail	177107	C57BL/6J
transcript	ENSMUST00000094569	Ensembl | MGI Sequence Detail	9778	Not Applicable
polypeptide	ENSMUSP00000092148	Ensembl | MGI Sequence Detail	1240	Not Applicable

All sequences(49) RefSeq(8) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(1448 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR026966	Fibronectin type III C-terminal domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR026965	Neurofascin
Protein Ontology	PR:000011162	neurofascin

References

(Earliest) J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
(Latest) J:184009 Buttermore ED, et al., Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci. 2012 Apr 4;32(14):4724-42
All references(51)

Other accession IDs

MGD-MRK-28044, MGI:2442229, MGI:3035338