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Nfasc Gene Detail
Summary
  • Symbol
    Nfasc
  • Name
    neurofascin
  • Synonyms
    D430023G06Rik, mKIAA0756, NF155, NF186
  • Feature Type
    protein coding gene
  • IDs
    MGI:104753
    NCBI Gene: 269116
  • Gene Overview
    MyGene.info: NFASC
Location & Maps
more
  • Sequence Map
    Chr1:132564690-132741797 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      177108 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.42 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NFASC, neurofascin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFASC, neurofascin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NF, NRCAML
  • Links
    NCBI Gene ID: 23114
    neXtProt AC: NX_O94856

  • Chr Location
    1q32.1; chr1:204828654-205022822 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 8 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    3
  • Genomic Mutations
    3 involving Nfasc
  • Incidental Mutations
Mice homozygous for a null allele die within 6 to 7 days of birth, exhibit reduced nerve conduction velocity and abnormal paranodal junction formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049394 VEGA Gene Model | MGI Sequence Detail 177108 C57BL/6J ±  kb
transcript OTTMUST00000125923 VEGA | MGI Sequence Detail 4927 Not Applicable  
polypeptide OTTMUSP00000068149 VEGA | MGI Sequence Detail 1347 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2032 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    cDNA 118
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28044, MGI:2442229, MGI:3035338
References
more
  • Summaries
    All 58
    Developmental Gene Expression 8
    Gene Ontology 14
    Phenotypes 22
  • Earliest
    J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
  • Latest
    J:219896 Zhang A, et al., Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015 Feb 4;35(5):2246-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory