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Nfasc
Gene Detail
Symbol

Name
ID
Nfasc
neurofascin
MGI:104753
Synonyms
D430023G06Rik, mKIAA0756, NF155, NF186
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:132564690-132741797 bp, - strand
From VEGA annotation of GRCm38

  177108 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFASC
Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Nfasc

Human
homologs
NFASC, neurofascin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23114
neXtProt AC: NX_O94856

Human Synonyms: NF, NRCAML

Human Chr (Location): 1q32.1; chr1:204828654-205022822 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele die within 6 to 7 days of birth, exhibit reduced nerve conduction velocity and abnormal paranodal junction formation.
 
Phenotype Images(1)
Interactions
Nfasc interacts with 460 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process axon guidance, cell adhesion, ...
Component axon, axon initial segment, ...
Function protein binding, protein binding involved in heterotypic cell-cell adhesion, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (59)    Tissues (9)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 59
cDNA source data(118)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfasc    NEW 
Molecular
reagents
All nucleic(119) cDNA(118) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049394 (Evidence)
Ensembl Gene Model ENSMUSG00000026442 (Evidence)
Entrez Gene 269116 (Evidence)
UniGene 326702
DFCI TC1578072, TC1584139, TC1602525, TC1606218, TC1612209, TC1626707, TC1650085
DoTS DT.101738051, DT.110918369, DT.40135206, DT.40142845, DT.55161513, DT.91403863, DT.99854297
NIA Mouse Gene Index U021764, U152485
Consensus CDS Project CCDS35707.1, CCDS48358.1, CCDS48359.1
International Mouse Phenotyping Consortium Status Nfasc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049394 VEGA Gene Model | MGI Sequence Detail 177108 C57BL/6J ±  kb
transcript OTTMUST00000125923 VEGA | MGI Sequence Detail 4927 Not Applicable 
polypeptide OTTMUSP00000068149 VEGA | MGI Sequence Detail 1347 Not Applicable 

For the selected sequences
All sequences(135) RefSeq(61) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(2033 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR026965 Neurofascin
InterPro IPR026966 Neurofascin/L1/NrCAM, C-terminal domain
Protein Ontology PR:000011162 neurofascin
References
(Earliest) J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
(Latest) J:219896 Zhang A, et al., Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015 Feb 4;35(5):2246-54
All references(60)
Other
accession IDs
MGD-MRK-28044, MGI:2442229, MGI:3035338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory