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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfasc
neurofascin
MGI:104753
25 phenotypes from 8 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfasctm1.1Brp/Nfasctm1.1Brp
B6.129P2-Nfasctm1.1Brp 		abnormal sciatic nerve morphology J:107591
decreased nerve conduction velocity J:107591
postnatal lethality, complete penetrance J:107591
Nfasctm1.1Brp/Nfasctm1.1Brp
involves: 129P2/OlaHsd * C57BL/6 		abnormal axon morphology J:139185
abnormal oligodendrocyte physiology J:139185
Nfasctm1.1Brp/Nfasctm1.1Brp
involves: 129P2/OlaHsd * ICR 		abnormal axon morphology J:166099
paralysis J:166099
postnatal lethality, complete penetrance J:166099
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Nefl-Nfasc)1Brp/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal axon morphology J:139185
abnormal oligodendrocyte physiology J:139185
normal nervous system phenotype J:139185
postnatal lethality, complete penetrance J:139185
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc)2Brp/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal axon morphology J:139185
normal nervous system phenotype J:139185
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp 		abnormal sciatic nerve morphology J:107591
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
involves: 129P2/OlaHsd * C57BL/6 		normal nervous system phenotype J:139185
Nfasctm1.1Brp/Nfasctm1.2Brp
Tg(Thy1-cre/ERT2)#Brp/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal action potential J:174740
abnormal axon initial segment morphology J:174740
abnormal gait J:174740
abnormal synapse morphology J:174740
impaired ability to fire action potentials J:174740
impaired balance J:174740
impaired coordination J:174740
normal nervous system phenotype J:174740
Nfasctm1a(EUCOMM)Hmgu/Nfasc+
C57BL/6N-Nfasctm1a(EUCOMM)Hmgu/Ics 		increased circulating triglyceride level J:165965
Nfasctm1Bhat/Nfasctm1Bhat
Cnptm1(cre)Kan/?
involves: 129S1/Sv * 129X1/SvJ 		abnormal axon morphology J:145846
abnormal limb posture J:145846
abnormal motor capabilities/coordination/movement J:145846
abnormal motor coordination/balance J:145846
abnormal Purkinje cell axon morphology J:145846
decreased locomotor activity J:145846
decreased nerve conduction velocity J:145846
impaired balance J:145846
impaired coordination J:145846
postnatal growth retardation J:145846
postnatal lethality, complete penetrance J:145846
weight loss J:145846
Nfasctm1Bhat/Nfasctm1Bhat
Tg(Mpz-cre)26Mes/?
involves: FVB/N 		abnormal motor capabilities/coordination/movement J:145846
decreased nerve conduction velocity J:145846
Nfasctm1Bhat/Nfasctm1Bhat
Tg(Plp1-cre/ERT)3Pop/?
involves: C57BL/6 * DBA/2 		abnormal axon morphology J:145846
decreased nerve conduction velocity J:145846
Nfasctm2Bhat/Nfasctm2Bhat
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129X1/SvJ 		abnormal paranodal axoglial junction morphology J:159621
abnormal paranode morphology J:159621
ataxia J:159621
impaired coordination J:159621
weight loss J:159621
Nfasctm2Bhat/Nfasctm2Bhat
Tmem163Tg(ACTB-cre)2Mrt/0
involves: FVB/N 		abnormal paranode morphology J:159621
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory