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Nfkbib
Gene Detail
Symbol

Name
ID
Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
MGI:104752
Synonyms
IKappaBbeta, IkB, MGC:36057
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.91 cM, cytoband A3-B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:28758251-28767512 bp, - strand
From VEGA annotation of GRCm38

  9262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NF-kappaB inhibitor
Gene Tree: Nfkbib

Human
homologs
Human Homolog NFKBIB, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NCBI Gene ID 4793
neXtProt AC  NX_Q15653
Human Synonyms  IKBB, TRIP9
Human Chr (Location)  19q13.1; chr19:38899507-38908894 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit decreased susceptibility to endotoxin shock and induced arthritis.
 
Interactions
Nfkbib interacts with 66 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cellular response to lipopolysaccharide, cytoplasmic sequestering of NF-kappaB, ...
Component cytoplasm, cytosol, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016845 (Evidence)
Ensembl Gene ModelENSMUSG00000030595 (Evidence)
Entrez Gene18036 (Evidence)
DFCITC1578970, TC1592802
DoTSDT.101382542, DT.111009960, DT.492670
NIA Mouse Gene IndexU028331
PDB1K3Z, 1OY3
Consensus CDS ProjectCCDS21054.1
International Mouse Knockout Project StatusNfkbib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016845 VEGA Gene Model | MGI Sequence Detail 9262 C57BL/6J ±  kb
transcript OTTMUST00000040926 VEGA | MGI Sequence Detail 2061 Not Applicable 
polypeptide OTTMUSP00000018308 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000003294 NF-kappa-B inhibitor beta
References
(Earliest) J:23294 Thompson JE, et al., I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell. 1995 Feb 24;80(4):573-82
(Latest) J:191066 Lin AE, et al., ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol. 2013 Jan;14(1):27-33
All references(55)
Other
accession IDs
MGD-MRK-28043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory