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Nfkbib Gene Detail
Summary
  • Symbol
    Nfkbib
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
  • Synonyms
    IKappaBbeta, IkB
  • Feature Type
    protein coding gene
  • IDs
    MGI:104752
    NCBI Gene: 18036
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28457676-28466069 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.91 cM, cytoband A3-B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104752
protein coding gene Chr7:28457676-28466937 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031959
protein coding gene Chr7:27595074-27606423 (-)
A/J MGP_AJ_G0031937
protein coding gene Chr7:26905119-26916072 (-)
AKR/J MGP_AKRJ_G0031869
protein coding gene Chr7:27597880-27607141 (-)
BALB/cJ MGP_BALBcJ_G0031944
protein coding gene Chr7:27064973-27074205 (-)
C3H/HeJ MGP_C3HHeJ_G0031663
protein coding gene Chr7:27973572-27982833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032408
protein coding gene Chr7:28497390-28506651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029460
protein coding gene Chr7:27966502-27975597 (-)
CAST/EiJ MGP_CASTEiJ_G0030998
protein coding gene Chr7:21293302-21302583 (-)
CBA/J MGP_CBAJ_G0031629
protein coding gene Chr7:29765398-29775151 (-)
DBA/2J MGP_DBA2J_G0031781
protein coding gene Chr7:26658003-26667264 (-)
FVB/NJ MGP_FVBNJ_G0031738
protein coding gene Chr7:26736271-26745907 (-)
LP/J MGP_LPJ_G0031861
protein coding gene Chr7:27918122-27927383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031774
protein coding gene Chr7:29236653-29245914 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032438
protein coding gene Chr7:27076385-27085644 (-)
PWK/PhJ MGP_PWKPhJ_G0030723
protein coding gene Chr7:21682427-21691777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030556
protein coding gene Chr7:18096574-18105835 (-)
WSB/EiJ MGP_WSBEiJ_G0031107
protein coding gene Chr7:27448427-27457785 (-)



Homology
more
  • Human Ortholog
    NFKBIB, NFKB inhibitor beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFKBIB, NFKB inhibitor beta
  • Synonyms
    IKBB, TRIP9
  • Links
    NCBI Gene ID: 4793
    neXtProt AC: NX_Q15653
    UniProt: Q15653

  • Chr Location
    19q13.2; chr19:38899666-38908893 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit decreased susceptibility to endotoxin shock and induced arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18036 NCBI Gene Model | MGI Sequence Detail 8394 C57BL/6J ±  kb
    transcript NM_010908 RefSeq | MGI Sequence Detail 2065 C57BL/6  
    polypeptide Q60778 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28043
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:23294 Thompson JE, et al., I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell. 1995 Feb 24;80(4):573-82
    • Latest
      J:321300 Adelaja A, et al., Six distinct NFkappaB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 2021 May 11;54(5):916-930.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory