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Cplx2 Gene Detail
Summary
  • Symbol
    Cplx2
  • Name
    complexin 2
  • Synonyms
    921-L, Gm34843
  • Feature Type
    protein coding gene
  • IDs
    MGI:104726
    NCBI Gene: 12890
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:54519162-54531730 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 28.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104726
 protein coding gene Chr13:54455447-54531736 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020567
 protein coding gene Chr13:53758261-53774684 (+)
A/J MGP_AJ_G0020521
 protein coding gene Chr13:51801256-51813603 (+)
AKR/J MGP_AKRJ_G0020499
 protein coding gene Chr13:53318569-53330918 (+)
BALB/cJ MGP_BALBcJ_G0020517
 protein coding gene Chr13:52015484-52027855 (+)
C3H/HeJ MGP_C3HHeJ_G0020316
 protein coding gene Chr13:53136472-53150601 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020951
 protein coding gene Chr13:55410671-55423062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018533
 protein coding gene Chr13:49790940-49803989 (+)
CAST/EiJ MGP_CASTEiJ_G0019830
 protein coding gene Chr13:53213385-53225313 (+)
CBA/J MGP_CBAJ_G0020276
 protein coding gene Chr13:57503257-57515625 (+)
DBA/2J MGP_DBA2J_G0020399
 protein coding gene Chr13:51364778-51377256 (+)
FVB/NJ MGP_FVBNJ_G0020378
 protein coding gene Chr13:50813631-50826860 (+)
LP/J MGP_LPJ_G0020475
 protein coding gene Chr13:54036747-54050056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020407
 protein coding gene Chr13:57017290-57029833 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020994
 protein coding gene Chr13:52904109-52918503 (+)
PWK/PhJ MGP_PWKPhJ_G0019586
 protein coding gene Chr13:51341177-51354206 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019413
 protein coding gene Chr13:51810343-51823032 (+)
WSB/EiJ MGP_WSBEiJ_G0019892
 protein coding gene Chr13:53242297-53255943 (+)



Homology
more
  • Human Ortholog
    CPLX2, complexin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPLX2, complexin 2
  • Synonyms
    921-L, CPX-2, CPX2, Hfb1
  • Links
    NCBI Gene ID: 10814
    UniProt: Q6PUV4

  • Chr Location
    5q35.2; chr5:175796310-175884021 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cplx2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    38
  • cDNA Data
    94
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025867 Ensembl Gene Model | MGI Sequence Detail 12569 C57BL/6J ±  kb
    transcript ENSMUST00000026985 Ensembl | MGI Sequence Detail 4928 Not Applicable  
    polypeptide ENSMUSP00000026985 Ensembl | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 1
      cDNA 95
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-27089, MGI:2145225, MGI:2145432, MGI:5594002
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:364901 Makke M, et al., Key determinants of the dual clamp/activator function of Complexin. Elife. 2024 Nov 25;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory