Cplx2
Gene Detail

Symbol Name ID

Cplx2 complexin 2 MGI:104726

Synonyms

921-L

Feature Type

protein coding gene

Genetic Map

Chromosome 13

28.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:54371349-54383917 bp, + strand From VEGA annotation of GRCm38   12569 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cplx2

Human homologs

Human Homolog		CPLX2, complexin 2
NCBI Gene ID		10814
neXtProt AC		NX_Q6PUV4
Human Synonyms		921-L, CPX2, CPX-2, Hfb1
Human Chr (Location)		5q35.2; chr5:175796539-175884021 (+)  GRCh38

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction.

 
Human Diseases Modeled Using Mouse Cplx2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell differentiation, exocytosis, ...
Component	cytoplasm, dendrite, ...
Function	calcium-dependent protein binding, SNARE binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (24)    Tissues (14)    Images (10)
Theiler Stages: 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	24

cDNA source data(93)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(96) Genomic(1) cDNA(94) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000032656 (Evidence)
Ensembl Gene Model	ENSMUSG00000025867 (Evidence)
Entrez Gene	12890 (Evidence)
UniGene	268902
DFCI	TC1587818, TC1604734, TC1625268, TC1652320
DoTS	DT.87071444, DT.99850693
NIA Mouse Gene Index	U014859
Consensus CDS Project	CCDS36667.1
International Mouse Knockout Project Status	Cplx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032656	VEGA Gene Model | MGI Sequence Detail	12569	C57BL/6J
transcript	OTTMUST00000081233	VEGA | MGI Sequence Detail	4928	Not Applicable
polypeptide	OTTMUSP00000062787	VEGA | MGI Sequence Detail	134	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(76 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008849	Synaphin
Protein Ontology	PR:000005810	complexin-2

References

(Earliest) J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
(Latest) J:205507 Yang X, et al., Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20777-82
All references(51)

Other accession IDs

MGD-MRK-27089, MGI:2145225, MGI:2145432