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Cplx2
Gene Detail
Symbol

Name
ID
Cplx2
complexin 2
MGI:104726
Synonyms
921-L
Feature Type
protein coding gene
Genetic Map
Chromosome 13
28.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:54371349-54383917 bp, + strand
From VEGA annotation of GRCm38

  12569 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CPLX2
Gene Tree: Cplx2

Human
homologs
CPLX2, complexin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10814
neXtProt AC: NX_Q6PUV4

Human Synonyms: 921-L, CPX2, CPX-2, Hfb1

Human Chr (Location): 5q35.2; chr5:175796539-175884021 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction.
 
Human Diseases Modeled in Mice Using Cplx2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Cplx2 interacts with 382 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, exocytosis, ...
Component cytoplasm, dendrite, ...
Function calcium-dependent protein binding, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (16)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(93)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase cplx2    NEW 
Molecular
reagents
All nucleic(96) Genomic(1) cDNA(94) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000032656 (Evidence)
Ensembl Gene Model ENSMUSG00000025867 (Evidence)
Entrez Gene 12890 (Evidence)
UniGene 268902
DFCI TC1587818, TC1604734, TC1625268, TC1652320
DoTS DT.87071444, DT.99850693
NIA Mouse Gene Index U014859
Consensus CDS Project CCDS36667.1
International Mouse Phenotyping Consortium Status Cplx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032656 VEGA Gene Model | MGI Sequence Detail 12569 C57BL/6J ±  kb
transcript OTTMUST00000081233 VEGA | MGI Sequence Detail 4928 Not Applicable 
polypeptide OTTMUSP00000062787 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005810 complexin-2
References
(Earliest) J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
(Latest) J:222594 Kurokawa A, et al., Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction. J Neurochem. 2015 Jun;133(6):806-814
All references(54)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-27089, MGI:2145225, MGI:2145432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory