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Cplx2
Gene Detail
Symbol

Name
ID
Cplx2
complexin 2
MGI:104726
Synonyms
921-L
Feature Type
protein coding gene
Genetic Map
Chromosome 13
28.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:54371349-54383917 bp, + strand
From VEGA annotation of GRCm38

  12569 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cplx2

Human
homologs
Human Homolog CPLX2, complexin 2
NCBI Gene ID 10814
neXtProt AC  NX_Q6PUV4
Human Synonyms  921-L, CPX2, CPX-2, Hfb1
Human Chr (Location)  5q35.2; chr5:175796539-175884021 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction.
 
Human Diseases Modeled Using Mouse Cplx2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cplx2 interacts with 383 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, exocytosis, ...
Component cytoplasm, dendrite, ...
Function calcium-dependent protein binding, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (16)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(93)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(96) Genomic(1) cDNA(94) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032656 (Evidence)
Ensembl Gene ModelENSMUSG00000025867 (Evidence)
Entrez Gene12890 (Evidence)
UniGene268902
DFCITC1587818, TC1625268, TC1604734, TC1652320
DoTSDT.99850693, DT.87071444
NIA Mouse Gene IndexU014859
Consensus CDS ProjectCCDS36667.1
International Mouse Knockout Project StatusCplx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032656 VEGA Gene Model | MGI Sequence Detail 12569 C57BL/6J ±  kb
transcript OTTMUST00000081233 VEGA | MGI Sequence Detail 4928 Not Applicable 
polypeptide OTTMUSP00000062787 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005810 complexin-2
References
(Earliest) J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
(Latest) J:210580 Lin MY, et al., Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol. 2013 May 15;591(Pt 10):2463-73
All references(53)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-27089, MGI:2145225, MGI:2145432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory