Cplx2
Gene Detail

Symbol

Name
ID

Cplx2
complexin 2
MGI:104726

Synonyms

921-L

Feature Type

protein coding gene

Genetic Map

Chromosome 13
28.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:54371349-54383917 bp, + strand From VEGA annotation of GRCm38   12569 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:38212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cplx2

Human
homologs

Human Homolog		CPLX2, complexin 2
NCBI Gene ID		10814
neXtProt AC		NX_Q6PUV4
Human Synonyms		921-L, CPX2, CPX-2, Hfb1
Human Chr (Location)		5q35.2; chr5:175796539-175884021 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction.

 
Human Diseases Modeled in Mice Using Cplx2 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Cplx2 interacts with 383 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	cell differentiation, exocytosis, ...
Component	cytoplasm, dendrite, ...
Function	calcium-dependent protein binding, SNARE binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (24)    Tissues (16)    Images (10)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	24

cDNA source data(93)
External Resources: GEO   Expression Atlas

Molecular
reagents

All nucleic(96) Genomic(1) cDNA(94) Other(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000032656 (Evidence)
Ensembl Gene Model	ENSMUSG00000025867 (Evidence)
Entrez Gene	12890 (Evidence)
UniGene	268902
DFCI	TC1652320, TC1587818, TC1604734, TC1625268
DoTS	DT.87071444, DT.99850693
NIA Mouse Gene Index	U014859
Consensus CDS Project	CCDS36667.1
International Mouse Knockout Project Status	Cplx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032656	VEGA Gene Model | MGI Sequence Detail	12569	C57BL/6J
transcript	OTTMUST00000081233	VEGA | MGI Sequence Detail	4928	Not Applicable
polypeptide	OTTMUSP00000062787	VEGA | MGI Sequence Detail	134	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(76 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008849	Synaphin
Protein Ontology	PR:000005810	complexin-2

References

(Earliest) J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
(Latest) J:210580 Lin MY, et al., Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol. 2013 May 15;591(Pt 10):2463-73
All references(53)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-27089, MGI:2145225, MGI:2145432