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Cplx2 Gene Detail
Summary
  • Symbol
    Cplx2
  • Name
    complexin 2
  • Synonyms
    921-L, Gm34843
  • Feature Type
    protein coding gene
  • IDs
    MGI:104726
    NCBI Gene: 12890
  • Gene Overview
    MyGene.info: CPLX2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:54371349-54383917 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12569 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 28.59 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CPLX2, complexin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPLX2, complexin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    921-L, CPX2, CPX-2, Hfb1
  • Links
    NCBI Gene ID: 10814
    neXtProt AC: NX_Q6PUV4
    UniProt: Q6PUV4

  • Chr Location
    5q35.2; chr5:175796539-175884021 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 38212
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CPLX2
  • Gene Tree
    Cplx2
Human Diseases
more
  • Diseases
    1 with Cplx2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    24
  • Tissues
    16
  • cDNA Data
    93
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032656 VEGA Gene Model | MGI Sequence Detail 12569 C57BL/6J ±  kb
    transcript OTTMUST00000081233 VEGA | MGI Sequence Detail 4928 Not Applicable  
    polypeptide OTTMUSP00000062787 VEGA | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      73 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      Genomic 1
      cDNA 94

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-27089, MGI:2145225, MGI:2145432, MGI:5594002
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 5
      Phenotypes 24
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:234628 Vardar G, et al., Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons. J Neurosci. 2016 Jul 27;36(30):7911-24
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory