Fdxr MGI Mouse Gene Detail - MGI:104724

Symbol

Fdxr
Name

ferredoxin reductase

Feature Type

protein coding gene
IDs

MGI:104724
NCBI Gene: 14149
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:115158850-115167876 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.84 cM, cytoband E2
Mapping Data

1 experiment

SNPs within 2kb

344 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104724	protein coding gene	Chr11:115158850-115167925 (-)
129S1/SvImJ	ENSMUSG00200049216	protein coding gene	Chr11:112529535-112538571 (-)
A/J	ENSMUSG00195025642	protein coding gene	Chr11:112231338-112240369 (-)
AKR/J	ENSMUSG00220026354	protein coding gene	Chr11:112332320-112341363 (-)
BALB/cJ	ENSMUSG00180047517	protein coding gene	Chr11:112530168-112539204 (-)
C3H/HeJ	ENSMUSG00175044786	protein coding gene	Chr11:112483232-112492263 (-)
C57BL/6NJ	ENSMUSG00215046132	protein coding gene	Chr11:112018700-112027728 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017393	protein coding gene	Chr11:111111793-111120944 (-)
CAST/EiJ	ENSTCUG00005034805	protein coding gene	Chr11:111887968-111897004 (-)
CBA/J	ENSMUSG00210047519	protein coding gene	Chr11:112203233-112212264 (-)
DBA/2J	ENSMUSG00185026478	protein coding gene	Chr11:112521916-112530942 (-)
FVB/NJ	ENSMUSG00205030052	protein coding gene	Chr11:112322183-112331209 (-)
JF1/MsJ	ENSUMUG00000019048	protein coding gene	Chr11:112792205-112801253 (-)
LP/J	ENSMUSG00230050382	protein coding gene	Chr11:113576638-113585670 (-)
NOD/ShiLtJ	ENSMUSG00190035361	protein coding gene	Chr11:112554058-112563094 (-)
NZO/HlLtJ	ENSMUSG00225051673	protein coding gene	Chr11:115632183-115641219 (-)
PWK/PhJ	ENSLUMG00010015590	protein coding gene	Chr11:112305766-112314814 (-)
SPRET/EiJ	ENSMSPG00010042839	protein coding gene	Chr11:112817321-112826764 (-)
WSB/EiJ	ENSIUOG00005041723	protein coding gene	Chr11:112292089-112301125 (-)

Human Ortholog

FDXR, ferredoxin reductase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FDXR, ferredoxin reductase
Synonyms

ADR, ADXR, ANOA, MMDS9B
Links

HGNC:3642

NCBI Gene ID: 2232

UniProt: P22570
Chr Location

17q25.1; chr17:74862494-74873039 (-) GRCh38

MGI Vertebrate Homology

Fdxr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FDXR
Protein SuperFamily

FNR
Gene Tree

Fdxr

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

33 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal embryonic development and embryonic lethality likely due to iron overload. Heterozygotes exhibit premature death and are prone to spontaneous tumors and liver abnormalities, including steatosis, hepatitis, and hepatocellular carcinoma.

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All GO Annotations

21
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

24

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fdxr

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All Sequences

41
RefSeq

4
UniProt

4
CCDS

CCDS25625.1

Ensembl

ENSMUSG00000018861 (Evidence)
NCBI Gene

14149

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018861	Ensembl Gene Model \| MGI Sequence Detail	9027	C57BL/6J	± kb
transcript	ENSMUST00000021078	Ensembl \| MGI Sequence Detail	1948	Not Applicable
polypeptide	ENSMUSP00000021078	Ensembl \| MGI Sequence Detail	494	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007452 NADPH:adrenodoxin oxidoreductase, mitochondrial

(term hierarchy)
EC

1.18.1.6
InterPro Domains

IPR023753 FAD/NAD(P)-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR021163 Ferredoxin-NADP+ reductase, adrenodoxin-type

IPR055275 Ferredoxin-NADP reductase-like
GlyGen

Q61578 2 sites

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All nucleic 25

Genomic 1

cDNA 24

Microarray probesets 4

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MGD-MRK-27087

Summaries

All 52

Diseases 1

Gene Ontology 13

Phenotypes 19
Earliest

J:29794 Itoh S, et al., cDNA cloning of mouse ferredoxin reductase from kidney. Biochim Biophys Acta. 1995 Nov 7;1264(2):159-62
Latest

J:360976 Zhang J, et al., Ferredoxin 2 Is Critical for Tumor Suppression and Lipid Homeostasis but Dispensable for Embryonic Development. Am J Pathol. 2024 Dec 26;

TSS for Fdxr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111741	Chr11:115167799-115167810 (-)	71 bp
Tssr111740	Chr11:115167778-115167798 (-)	88 bp
Tssr111739	Chr11:115167742-115167769 (-)	120 bp
Tssr111738	Chr11:115167718-115167732 (-)	151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24