Fgf9
Gene Detail

Symbol Name ID

Fgf9 fibroblast growth factor 9 MGI:104723

Synonyms

Eks, glia activating factor

Feature Type

protein coding gene

Genetic Map

Chromosome 14

30.51 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr14:58070547-58112337 bp, + strand From VEGA annotation of GRCm38   41791 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf9

Human homologs

Human Homolog		FGF9, fibroblast growth factor 9 (glia-activating factor)
NCBI Gene ID		2254
neXtProt AC		NX_P31371
Human Synonyms		GAF, HBFG-9, SYNS3
Human Chr (Location)		13q11-q12; chr13:22245215-22278640 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FGF9

Alleles and phenotypes

All alleles(8) : Targeted(6) Spontaneous(1) Chemically induced(1)
 

Homozygotes for a targeted null mutation exhibit reduced size, pulmonary hypoplasia, cardiac dilation, impaired testes development resulting in male-to-female sex reversal, abnormal retina, and neonatal lethality.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	angiogenesis, cardiac left ventricle morphogenesis, ...
Component	basement membrane, cytoplasm, ...
Function	fibroblast growth factor receptor binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (113 records)
Data Summary: Results (277)    Tissues (223)    Images (40)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	167
RT-PCR	110

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(33) Primer pair(8) Other(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000036883 (Evidence)
Ensembl Gene Model	ENSMUSG00000021974 (Evidence)
Entrez Gene	14180 (Evidence)
UniGene	8846
DFCI	TC1589976, TC1699573
DoTS	DT.40158105, DT.40161358, DT.486271, DT.91321776
NIA Mouse Gene Index	U015703, U283460
Consensus CDS Project	CCDS27164.1
International Mouse Knockout Project Status	Fgf9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036883	VEGA Gene Model | MGI Sequence Detail	41791	C57BL/6J
transcript	OTTMUST00000094754	VEGA | MGI Sequence Detail	1593	Not Applicable
polypeptide	OTTMUSP00000052767	VEGA | MGI Sequence Detail	208	Not Applicable

All sequences(53) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(2) : SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR002209	Heparin-binding growth factor/Fibroblast growth factor
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007500	glia-activating factor

References

(Earliest) J:35382 Miyamoto M, et al., Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol Cell Biol. 1993 Jul;13(7):4251-9
(Latest) J:193313 Takase HM, et al., FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013 Jan 15;27(2):169-81
All references(176)

Other accession IDs

MGD-MRK-27086, MGI:2182125