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Fgf9 Gene Detail
Summary
  • Symbol
    Fgf9
  • Name
    fibroblast growth factor 9
  • Synonyms
    Eks, glia activating factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:104723
    NCBI Gene: 14180
  • Gene Overview
    MyGene.info: FGF9
Location & Maps
more
  • Sequence Map
    Chr14:58070547-58112337 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41791 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 30.51 cM, cytoband D
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FGF9, fibroblast growth factor 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGF9, fibroblast growth factor 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGF-9, GAF, HBFG-9, HBGF-9, SYNS3
  • Links
    NCBI Gene ID: 2254
    neXtProt AC: NX_P31371

  • Chr Location
    13q12.11; chr13:21671076-21704501 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Fgf9 mouse models; 1 with human FGF9 associations

Human Disease Mouse Models
       Lung Cancer   OMIM: 211980 View 1 model
Pleuropulmonary Blastoma; PPB   OMIM: 601200 View 1 model
       Multiple Synostoses Syndrome 3; SYNS3   OMIM: 612961
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    114 phenotypes from 8 alleles in 11 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Spontaneous
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    1 involving Fgf9
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit reduced size, pulmonary hypoplasia, cardiac dilation, impaired testes development resulting in male-to-female sex reversal, abnormal retina, and neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036883 VEGA Gene Model | MGI Sequence Detail 41791 C57BL/6J ±  kb
transcript OTTMUST00000094754 VEGA | MGI Sequence Detail 1593 Not Applicable  
polypeptide OTTMUSP00000052767 VEGA | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    135 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 36
    Primer pair 9
    Other 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-27086, MGI:2182125
References
more
  • Summaries
    All 208
    Developmental Gene Expression 141
    Diseases 2
    Gene Ontology 23
    Phenotypes 50
  • Earliest
    J:35382 Miyamoto M, et al., Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol Cell Biol. 1993 Jul;13(7):4251-9
  • Latest
    J:233746 Wang X, et al., Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Dev Biol. 2016 Jun 15;414(2):161-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory