Phenotypes Associated with This Genotype

Genotype
MGI:6161223

• Allelic Composition: Fgf9^tm1Zgwg/Fgf9⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal voluntary movement ( J:241783 )

• dyskinesia of elbow and/or knee joints

craniofacial

abnormal incisor morphology ( J:241783 )

• 9% of mice exhibit overgrowth of incisors

misaligned incisors ( J:241783 )

• in 9% of mice

abnormal tooth development ( J:241783 )

• 9% of mice exhibit abnormal tooth development, with overgrowth and non-alignment of incisor teeth

growth/size/body

abnormal incisor morphology ( J:241783 )

• 9% of mice exhibit overgrowth of incisors

misaligned incisors ( J:241783 )

• in 9% of mice

abnormal tooth development ( J:241783 )

• 9% of mice exhibit abnormal tooth development, with overgrowth and non-alignment of incisor teeth

limbs/digits/tail

curly tail ( J:241783 )

skeleton

abnormal incisor morphology ( J:241783 )

• 9% of mice exhibit overgrowth of incisors

misaligned incisors ( J:241783 )

• in 9% of mice

abnormal tooth development ( J:241783 )

• 9% of mice exhibit abnormal tooth development, with overgrowth and non-alignment of incisor teeth

abnormal coccyx morphology ( J:241783 )

• malalignment of the tail bone

abnormal joint morphology ( J:241783 )

• mice that exhibit fusions of the elbow and knee joints have enhanced bone density in the joints

abnormal intervertebral disk morphology ( J:241783 )

• the intervertebral disk disappears in areas of synostosis between adjacent caudate vertebra

fused joints ( J:241783 )

• 5.5% of 3 month old mice exhibit partial or complete fusions of the elbow and knee joints and enhanced bone density

vertebral fusion ( J:241783 )

• fusion of vertebrae joints

synostosis ( J:241783 )

• the abnormal joints of caudate vertebrae have synostosis between adjacent vertebrae and the intervertebral disk has disappeared

increased bone ossification ( J:241783 )

• the articular surface of the femur and tibia are destroyed and fused with an enhancement of ossification

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple synostoses syndrome		DOID:0050794	OMIM:PS186500	J:241783