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Ndst1
Gene Detail
Symbol

Name
ID
Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
MGI:104719
Synonyms
1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.38 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:60685978-60713389 bp, - strand
From Ensembl annotation of GRCm38

  27412 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDST1
Protein SuperFamily: heparan sulfate N-sulfotransferase 3
Gene Tree: Ndst1

Human
homologs
NDST1, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3340
neXtProt AC: NX_P52848

Human Synonyms: HSST, MRT46, NST1

Human Chr (Location): 5q33.1; chr5:150485823-150558211 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NDST1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die late in gestation or neonatally. Lungs fail to inflate and mice born alive experience respiratory distress and failure.
 
Human Diseases Modeled in Mice Using Ndst1 (3)    Mutations Annotated to Human Diseases (4)    Phenotype Images(20)
Interactions
Ndst1 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (165)    Tissues (134)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
RT-PCR 48
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ndst1    NEW 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000054008 (Evidence)
Entrez Gene 15531 (Evidence)
DFCI TC1598734, TC1597582, TC1585281
DoTS DT.40148964, DT.110780598, DT.101715826, DT.101247769, DT.101385716, DT.101284889, DT.91350768, DT.483930, DT.91432267
NIA Mouse Gene Index U038460
EC 3.-.-.-, 2.8.2.-, 2.8.2.8
Consensus CDS Project CCDS37834.1
International Mouse Phenotyping Consortium Status Ndst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054008 Ensembl Gene Model | MGI Sequence Detail 27412 C57BL/6J ±  kb
transcript ENSMUST00000169273 Ensembl | MGI Sequence Detail 6070 Not Applicable 
polypeptide ENSMUSP00000126623 Ensembl | MGI Sequence Detail 882 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(20) UniProt(1)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021930 Heparan sulphate-N-deacetylase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000011063 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
References
(Earliest) J:17539 Eriksson I, et al., cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem. 1994 Apr 8;269(14):10438-43
(Latest) J:214777 Goulbourne CN, et al., The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 6;19(5):849-60
All references(77)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-27082, MGI:1921391, MGI:5491170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory