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Ndst1
Gene Detail
 Symbol
Name
ID
Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
MGI:104719
Synonyms 1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1
Feature Type protein coding gene
Genetic Map
Chromosome 18
34.38 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:60685978-60713389 bp, - strand
From Ensembl annotation of GRCm38

  27412 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: heparan sulfate N-sulfotransferase 3
Gene Tree: Ndst1

Human
homologs
Human Homolog NDST1, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NCBI Gene ID 3340
neXtProt AC  NX_P52848
Human Synonyms  HSST, NST1
Human Chr (Location)  5q33.1; chr5:150485805-150558211 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die late in gestation or neonatally. Lungs fail to inflate and mice born alive experience respiratory distress and failure.
 
Human Diseases Modeled Using Mouse Ndst1 (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(20)
Interactions
Ndst1 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process embryo development, embryonic neurocranium morphogenesis, ...
Component Golgi apparatus, integral component of membrane, ...
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (165)    Tissues (131)    Images (7)
Theiler Stages: 10, 16, 18, 19, 20, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 117
RT-PCR 48
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000054008 (Evidence)
Entrez Gene15531 (Evidence)
DFCITC1585281, TC1597582, TC1598734
DoTSDT.101247769, DT.101284889, DT.101385716, DT.101715826, DT.110780598, DT.40148964, DT.483930, DT.91350768, DT.91432267
NIA Mouse Gene IndexU038460
EC2.8.2.-, 3.-.-.-, 2.8.2.8
Consensus CDS ProjectCCDS37834.1
International Mouse Knockout Project StatusNdst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054008 Ensembl Gene Model | MGI Sequence Detail 27412 C57BL/6J ±  kb
transcript ENSMUST00000169273 Ensembl | MGI Sequence Detail 6070 Not Applicable 
polypeptide ENSMUSP00000126623 Ensembl | MGI Sequence Detail 882 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(18) UniProt(1)
Polymorphisms SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021930 Heparan sulphate-N-deacetylase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000011063 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
References (Earliest) J:17539 Eriksson I, et al., cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem. 1994 Apr 8;269(14):10438-43
(Latest) J:209931 Yin X, et al., Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014 Mar 1;192(5):2133-42
All references(76)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-27082, MGI:1921391, MGI:5491170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory