Ndst1^tm1Je
Targeted Allele Detail

Summary

• Symbol: Ndst1^tm1Je
• Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Jeffrey D Esko
• MGI ID: MGI:3589211
• Synonyms: Ndst1^f
• Gene: Ndst1 Location: Chr18:60817566-60881722 bp, - strand Genetic Position: Chr18, 34.38 cM, cytoband D2
• Alliance: Ndst1^tm1Je page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100456
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2, including part of the 5' untranslated region, the start codon and sequence encoding 171 amino acids, including the cytoplasmic tail, transmembrane region and part of the N-deacetylase domain. (J:100456)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ndst1 Mutation: 46 strains or lines available

References

• Original: J:100456 Wang L, et al., Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol. 2005 Sep;6(9):902-10
• All: 29 reference(s)